Implantable device for producing hydrogen

Patent metadata

Field	Value
Publication number	US-11660314-B2
Application number	US-201816956842-A
Country	US
Kind code	B2
Filing date	Dec 21, 2018
Priority date	Dec 22, 2017
Publication date	May 30, 2023
Grant date	May 30, 2023

Abstract

A device intended to be implanted in a human or animal body, in order to produce hydrogen in situ from molecules present in the body medium in which the device is implanted, this device having an anode and a cathode, which are each electrically connected to a pole of an electrical energy source, and having a semi-permeable material separating the electrodes from the body medium, in which device, when the connection to the electrical energy source is effective in situ, in the presence of body fluid, a closed electrical circuit is formed, with production of hydrogen at the cathode, the semi-permeable material having a cutoff threshold of between 50 and 500 Da.

First claim

The invention claimed is:

1. A device intended to be implanted in a human or animal body, in order to produce hydrogen in situ from molecules present in a body medium in which the device is implanted, this device comprising two electrodes: an anode and a cathode, the anode is electrically connected to a pole of an electrical energy source and the cathode is electrically connected to an other pole of the electrical energy source, and comprising a semi-permeable material separating the electrodes from the body medium, and wherein, when the connection to the electrical energy source is effective in situ, in the presence of body fluid, a closed electrical circuit is formed, with production of hydrogen at the cathode, the semi-permeable material having a cutoff threshold of between 50 and 500 Da.

2. The device according to claim 1 , wherein the semi-permeable material has a cutoff threshold between 50 and 500 Da, and the device is intended to induce electrolysis of water, with production of dioxygen at the anode.

3. The device according to claim 2 , wherein the electrodes are individually or collectively separated from the body medium by the semi-permeable material.

4. The device according to claim 1 , wherein the semi-permeable material has a cutoff threshold between 200 and 500 Da, and wherein the anode contains or carries an enzyme able to catalyse the oxidation of a carbohydrate at the anode.

5. The device according to claim 4 , wherein the electrodes are individually and/or collectively separated from the body medium by the semi-permeable material and wherein the anode and cathode are separated one from the other by a semi-permeable membrane or by a proton exchange membrane.

6. The device according to claim 1 , wherein the semi-permeable material that separates the electrodes from the body medium is formed by a semi-permeable membrane that surrounds the two electrodes, or by a semi-permeable membrane that surrounds each electrode.

7. The device according to claim 1 , wherein the semi-permeable material that separates the electrodes from the body medium forms a portion of a container that encloses the electrodes.

8. The device according to claim 1 , wherein the semi-permeable material that separates the electrodes from the body medium consists of a three-dimensional porous matrix, in at least one block, containing the two electrodes.

9. The device according to claim 5 , wherein the semi-permeable material is surrounded by a biocompatible surface layer and with anti-biofouling property, also in semi-permeable material for separation with the body medium, or the semi-permeable material has an anti-biofouling property.

10. The device according to claim 1 , wherein the semi-permeable material is polyvinyl alcohol (PVA).

11. The device according to claim 1 , wherein the electrodes are made of or comprise: carbon; platinum; gold.

12. The device according to claim 1 , wherein the anode contains or carries an enzyme able to catalyse the oxidation of the glucose at the anode, the enzyme being chosen from among glucose oxidase and glucose dehydrogenase, and a catalase able to be used as a second catalyst when the enzyme is glucose dehydrogenase.

13. The device according to claim 1 , wherein the electrical energy source is one of a battery; a biobattery able to produce electricity by consuming chemical species that are naturally present in a human or animal organism; a mechanical device that recovers piezoelectric energy.

14. The device according to claim 1 , wherein said device has dimensions that represent a volume less than or equal to 12 ml.

15. The device according to claim 1 , wherein the electrical energy source produces a voltage of at least about 1.3 V and a power of at least about 5 microWatts.

16. The device according to claim 1 , wherein the anode and cathode are separated by a distance between about 0.1 mm and about 1 cm.

17. A method for in vivo production of hydrogen and/or oxygen inside a human or animal body, comprising
an implantation of at least one device according to claim 1 in the human or animal body,
an operation of the device to produce hydrogen and/or oxygen inside in the human or animal body.

18. The method according to claim 17 , further comprising electrically connecting the device to a remote electrical energy source.

19. The method according to claim 17 , wherein the operation of the device comprises controlling closing and opening of the electrical circuit by an element for controlling the opening and the closing of the electrical circuit.

Assignees

• Univ Grenoble Alpes
• Centre Hospitalier Univ Grenoble Alpes
• Inst Nat Sante Rech Med

Inventors

• Cinquin Philippe
• Zebda Abdelkader
• Alcaraz Jean-Pierre
• Martin Donald Keith

Classifications

• A61N1/32

  alternating or intermittent currents {(applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02)} · CPC title

• A61N1/05

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61K9/0024

  Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title

• A61K33/00 Primary

  Medicinal preparations containing inorganic active ingredients · CPC title

• Y02E60/36

  Hydrogen production from non-carbon containing sources, e.g. by water electrolysis · CPC title