Flexible substrates with chemical and moisture resistance

Patent metadata

Field	Value
Publication number	US-11654667-B2
Application number	US-202016864927-A
Country	US
Kind code	B2
Filing date	May 1, 2020
Priority date	May 6, 2019
Publication date	May 23, 2023
Grant date	May 23, 2023

Abstract

Flexible packages, transdermal drug delivery devices, and methods for fabricating packages are provided. An exemplary flexible package includes a chemical and moisture resistant layer formed from poly(chlorotrifluoroethylene-co-vinylidene fluoride) (“P(CTFE-co-VDF)”) copolymer. Further, the exemplary flexible package includes a substance to be delivered. The substance is applied to or enclosed by the chemical and moisture resistant layer.

First claim

What is claimed is:

1. A transdermal drug delivery device comprising:
a chemical and moisture resistant layer comprising poly(chlorotrifluoroethylene-co-vinylidene fluoride) (“P(CTFE-co-VDF)”) copolymer, wherein the P(CTFE-co-VDF) copolymer comprises no more than about 5 wt. % vinylidene fluoride (“VDF”), based on the total weight of the copolymer, wherein the chemical and moisture resistant layer has a first side and a second side;
a second layer releasably connected to the second side of the chemical and moisture resistant layer; and
a drug located between the second side of the chemical and moisture resistant layer and the second layer,
wherein the first side of the chemical and moisture resistant layer forms an outermost surface of the transdermal drug delivery device.

2. The transdermal drug delivery device of claim 1 wherein the chemical and moisture resistant layer comprises a co-extrusion of P(CTFE-co-VDF) copolymer and an acrylonitrile copolymer, cyclic olefin copolymer (COC), polyethylene terephthalate (PET), foil, and/or biaxially oriented polyamide (BOPA).

3. The transdermal drug delivery device of claim 1 wherein the chemical and moisture resistant layer comprises a laminate structure including a layer of P(CTFE-co-VDF) copolymer and a layer of an acrylonitrile copolymer, cyclic olefin copolymer (COC), polyethylene terephthalate (PET), foil, and/or biaxially oriented polyamide (BOPA).

4. The transdermal drug delivery device of claim 1 wherein the drug is dispersed in a matrix, and wherein the matrix directly contacts the chemical and moisture resistant layer and the second layer.

5. The transdermal drug delivery device of claim 1 wherein the second layer comprises P(CTFE-co-VDF) copolymer, wherein the P(CTFE-co-VDF) copolymer comprises no more than about 5 wt. % vinylidene fluoride (VDF), based on the total weight of the copolymer.

6. The transdermal drug delivery device of claim 1 wherein no material layer is interposed between the drug and the second side of the chemical and moisture resistant layer.

7. The transdermal drug delivery device of claim 1 wherein the drug is dispersed in a matrix, wherein the matrix has a front side and a back side, wherein the front side is in direct contact with the second layer, and wherein all of the back side is in direct contact with the second side of the chemical and moisture resistant layer.

8. The transdermal drug delivery device of claim 1 wherein the drug is dispersed in a matrix, wherein the matrix has a front side and a back side, and wherein no material layer is interposed between the back side and the second side of the chemical and moisture resistant layer.

9. The transdermal drug delivery device of claim 1 wherein the second layer is releasably connected to the second side of the chemical and moisture resistant layer by the drug located between the second side of the chemical and moisture resistant layer and the second layer.

10. The transdermal drug delivery device of claim 1 wherein the second layer is releasably connected to the second side of the chemical and moisture resistant layer by the drug located between the second side of the chemical and moisture resistant layer and the second layer, and wherein the transdermal drug delivery device consists of the chemical and moisture resistant layer, the drug, and the second layer.

11. The transdermal drug delivery device of claim 1 wherein the transdermal drug delivery device consists of the chemical and moisture resistant layer, the drug, and the second layer.

12. The transdermal drug delivery device of claim 1 further comprising an adhesive for adhering the drug to the chemical and moisture resistant layer, wherein the transdermal drug delivery device consists of the chemical and moisture resistant layer, the drug, the second layer, and the adhesive.

13. The transdermal drug delivery device of claim 2 wherein the chemical and moisture resistant layer comprises a co-extrusion of P(CTFE-co-VDF) copolymer and an acrylonitrile copolymer.

14. The transdermal drug delivery device of claim 2 wherein the chemical and moisture resistant layer comprises a co-extrusion of P(CTFE-co-VDF) copolymer and a cyclic olefin copolymer (COC).

15. The transdermal drug delivery device of claim 2 wherein the chemical and moisture resistant layer comprises a co-extrusion of P(CTFE-co-VDF) copolymer and a polyethylene terephthalate (PET).

16. The transdermal drug delivery device of claim 2 wherein the chemical and moisture resistant layer comprises a co-extrusion of P(CTFE-co-VDF) copolymer and a foil.

17. The transdermal drug delivery device of claim 2 wherein the chemical and moisture resistant layer comprises a co-extrusion of P(CTFE-co-VDF) copolymer and a biaxially oriented polyamide (BOPA).

18. The transdermal drug delivery device of claim 3 wherein the chemical and moisture resistant layer comprises a laminate structure including a layer of P(CTFE-co-VDF) copolymer and a layer of a cyclic olefin copolymer (COC), polyethylene terephthalate (PET), and/or biaxially oriented polyamide (BOPA).

19. A transdermal drug delivery device comprising:
a chemical and moisture resistant layer comprising poly(chlorotrifluoroethylene-co-vinylidene fluoride) (“P(CTFE-co-VDF)”) copolymer, wherein the P(CTFE-co-VDF) copolymer comprises no more than about 5 wt. % vinylidene fluoride (“VDF”), based on the total weight of the copolymer, wherein the chemical and moisture resistant layer has a first side and a second side;
a second layer releasably connected to the second side of the chemical and moisture resistant layer; and
a drug located between the second side of the chemical and moisture resistant layer and the second layer, wherein the drug is dispersed in a matrix, wherein the matrix has a back side extending from a first edge to a second edge, and wherein the back side is in continuous contact with the chemical and moisture resistant layer from the first edge to the second edge.

20. A transdermal drug delivery device consisting of:
a chemical and moisture resistant layer comprising poly(chlorotrifluoroethylene-co-vinylidene fluoride) (“P(CTFE-co-VDF)”) copolymer, wherein the P(CTFE-co-VDF) copolymer comprises no more than about 5 wt. % vinylidene fluoride (“VDF”), based on the total weight of the copolymer, wherein the chemical and moisture resistant layer has a first side and a second side;
a second layer releasably connected to the second side of the chemical and moisture resistant layer; and
a drug located between the second side of the chemical and moisture resistant layer and the second layer.

Assignees

• Honeywell Int Inc

Inventors

• Skwarek Gary M
• Altman Carl
• Lee Jong
• Rainal Eric
• Kerkar Awdhoot Vasant
• Thenappan Alagappan

Classifications

• B32B2307/732

  Dimensional properties · CPC title

• B32B2307/714

  Inert, i.e. inert to chemical degradation, corrosion · CPC title

• B32B2307/516

  mono-axially · CPC title

• B29C48/022

  characterised by the choice of material · CPC title

• B32B27/36

  comprising polyesters · CPC title