Light emitting droplets and related methods

Patent metadata

Field	Value
Publication number	US-11654404-B2
Application number	US-201916415353-A
Country	US
Kind code	B2
Filing date	May 17, 2019
Priority date	May 18, 2018
Publication date	May 23, 2023
Grant date	May 23, 2023

Abstract

Embodiments described herein may be useful for optofluidic devices. For example, optofluidic devices using dynamic fluid lens materials represent an ideal platform to create versatile, reconfigurable, refractive optical components. For example, the articles described herein may be useful as fluidic tunable compound micro-lenses. Such compound micro-lenses may be composed of two or more components (e.g., two or more inner phases) that form stable bi-phase emulsion droplets in outer phases (e.g., aqueous media). In some embodiments, the articles described herein may be useful as light emitting droplets. Advantageously, the plurality of droplets may be configured such that light rays may modified (e.g., via stimulation of the droplets, exposure to an analyte such as a pathogen) to have a detectable emission intensity and/or angle of maximum emission intensity under a particular set of conditions.

First claim

What is claimed is:

1. An article, comprising:
a plurality of droplets dispersed within an outer phase, wherein:
the plurality of droplets comprise a first component and a second component immiscible with the first component under a first set of conditions,
the plurality of droplets have a first average radius of curvature between the first component and the second component that causes light rays to have a first emission intensity at a given emission direction under the first set of conditions, and
the plurality of droplets have a second average radius of curvature between the first component and the second component that causes light rays to have a second emission intensity at the given emission direction, different than the first emission intensity, under a second set of conditions, different than the first set of conditions.

2. An article, comprising:
a plurality of droplets dispersed within an outer phase, wherein:
the plurality of droplets comprise a first component and a second component immiscible with the first component under a first set of conditions,
the plurality of droplets have a first average radius of curvature between the first component and the second component that causes light rays to have a first angle of maximum emission intensity under the first set of conditions, and
the plurality of droplets have a second average radius of curvature between the first component and the second component that causes light rays to have a second angle of maximum emission intensity, different than the first angle, under a second set of conditions, different than the first set of conditions.

3. An article as in claim 2 , wherein at least a portion of the plurality of droplets are aligned.

4. An article as in claim 2 , wherein the plurality of droplets comprise a surfactant comprising boronic acid.

5. A device as in claim 2 , wherein the plurality of droplets comprise a dye.

6. A device as in claim 2 , wherein the first component comprises a first dye and the second component comprises a second dye, different than the first dye.

7. A device as in claim 2 , wherein the plurality of droplets are configured to detect carbohydrates and/or pathogens such as Salmonella.

8. A device as in claim 2 , wherein the plurality of droplets are configured to reversibly bind, at a surface of the droplets, to an analyte such that the act of binding or unbinding of the analyte changes the average focal length of a transmitted light through the plurality of droplets.

9. A device as in claim 2 , wherein the plurality of droplets are configured to reversibly bind, at a surface of the droplets, to an analyte such that the act of binding or unbinding of the analyte changes a direction of light emission from the plurality of droplets.

Assignees

• Massachusetts Inst Technology

Inventors

• Swager Timothy M
• Nagelberg Sara N
• Kolle Mathias
• Zeininger Lukas
• Harvey Kent
• Herbert Myles

Classifications

• B01L3/502784

  specially adapted for droplet or plug flow, e.g. digital microfluidics · CPC title

• G01N21/59

  Transmissivity (G01N21/25 takes precedence) · CPC title

• B01F23/4145

  Emulsions of oils, e.g. fuel, and water · CPC title

• B01F23/41 Primary

  Emulsifying · CPC title

• B01F25/14

  Mixing drops, droplets or bodies of liquid which flow together or contact each other (micromixers using where the materials to be mixed are in the form of droplets B01F33/302) · CPC title