Method for controlling ultrafast chemical reaction using a microfluidic reactor fabricated by high-resolution 3D metal printing technique

Patent metadata

Field	Value
Publication number	US-11648524-B2
Application number	US-202117387932-A
Country	US
Kind code	B2
Filing date	Jul 28, 2021
Priority date	Jul 29, 2020
Publication date	May 16, 2023
Grant date	May 16, 2023

Abstract

The present invention relates to a method for controlling an ultrafast chemical reaction using a microfluidic reactor, and more specifically, the present invention relates to a method for controlling an ultrafast chemical reaction such as the Fries rearrangement reaction and the like by using a microfluidic reactor by the 3D metal printing technique.

First claim

The invention claimed is:

1. A method for controlling a chemical reaction using a microreactor having a flow channel with a circular cross section, wherein the flow channel is produced by a selective laser melting (SLM) method.

2. The method of claim 1 , wherein the chemical reaction is an ultrafast chemical reaction.

3. The method of claim 2 , wherein the ultrafast chemical reaction is the Fries Rearrangements.

4. The method of claim 1 , wherein the flow channel is formed such that a flow path for injecting a first fluid, a flow path for injecting a second fluid, and a merging path of the first fluid and the second fluid form a T shape.

5. The method of claim 1 , wherein the flow channel is 3D printed.

6. The method of claim 1 , wherein the microreactor is composed of a metal.

7. The method of claim 6 , wherein the metal is stainless steel.

8. The method of claim 1 , wherein the chemical reaction uses a compound of Chemical Formula 1 below as a starting material to obtain a compound of Chemical Formula 2a below

9. The method of claim 1 , wherein the chemical reaction uses a compound of Chemical Formula 3 below to obtain a compound of Chemical Formula 4 below

10. A microreactor for controlling an ultrafast chemical reaction of sub-millisecond, comprising a flow channel formed such that a flow path for injecting a first fluid, a flow path for injecting a second fluid, and a merging path of the first fluid and the second fluid form a T shape, wherein the flow channel has a circular cross section with a diameter of 170 μm, and the flow channel is produced by a selective laser melting (SLM) method.

11. The microreactor of claim 10 , wherein the ultrafast chemical reaction of sub-millisecond is the Fries Rearrangements.

12. A method for using a compound of Chemical Formula 1 below as a starting material to obtain a compound of Chemical Formula 2a below, by using a microreactor having a flow channel with a circular cross section, wherein the flow channel is produced by a selective laser melting (SLM) method

13. A method for using a compound of Chemical Formula 3 below as a starting material to obtain a compound of Chemical Formula 4 below, by using a microreactor having a flow channel with a circular cross section, wherein the flow channel is produced by a selective laser melting (SLM) method

Assignees

• Postech Acad Ind Found
• Versitech Ltd

Inventors

• Kim Dong Pyo
• Kim Ji Tae
• Lee Hyune Jea

Classifications

• B33Y80/00 Primary

  Products made by additive manufacturing · CPC title

• B01J19/0093 Primary

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title

• C07C213/08

  by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups · CPC title

• C22C33/0285

  with Cr, Co, or Ni having a minimum content higher than 5% · CPC title

• C07F7/2208

  Compounds having tin linked only to carbon, hydrogen and/or halogen · CPC title