Medical fluid injector

Patent metadata

Field	Value
Publication number	US-11648346-B2
Application number	US-201916687034-A
Country	US
Kind code	B2
Filing date	Nov 18, 2019
Priority date	Mar 15, 2013
Publication date	May 16, 2023
Grant date	May 16, 2023

Abstract

Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

First claim

The invention claimed is:

1. A system for delivering a fluid to a targeted tissue in accordance with an injection protocol having at least two phases, the system comprising:
a pump configured to contain a volume of the fluid;
a sensing system;
a processor in operable communication with the pump and the sensing system, wherein the processor is configured to:
control the pump to deliver the fluid to the targeted tissue based on a first predetermined value of a first controlled parameter in accordance with each of a first phase and a second phase of the injection protocol;
during each of the first phase and the second phase, receive one or more signals from the sensing system corresponding to a first limiting parameter, wherein the first limiting parameter comprises at least one of: a pressure at the pump, a flow rate at the pump, a pressure in a receiving vessel, a pressure in the targeted tissue, an image property, a tissue stretch property, a tissue conductivity, a tissue ultrasound property, a flow rate in the targeted tissue, a fluid cell count, a fluid particle count, and a density of a measurable tracer;
during each of the first phase and the second phase, determine whether the first limiting parameter is outside an acceptable range of the first limiting parameter;
during each of the first phase and the second phase, determine an adjusted value of the first controlled parameter in response to determining that the first limiting parameter is outside the acceptable range of the first limiting parameter; and
during each of the first phase and the second phase, control the pump to deliver the fluid to the targeted tissue based on the adjusted value of the first controlled parameter,
wherein the acceptable range of the first limiting parameter is different during the first phase than during the second phase.

2. The system of claim 1 , wherein the first controlled parameter comprises at least one of an injection pressure, an injection flow rate, an injection volume, the pressure in the targeted tissue, and the flow rate in the targeted tissue.

3. The system of claim 1 , wherein the acceptable range of the first limiting parameter is based on at least one of a threshold at which the targeted tissue will be damaged and a mechanical capacity of the pump.

4. The system of claim 1 , wherein the processor is further configured to:
control the pump to deliver the fluid to the targeted tissue based on a second predetermined value of a second controlled parameter, and
wherein the second controlled parameter is equal to or different than the first controlled parameter.

5. The system of claim 1 , wherein the one or more signals further correspond to a duration parameter, wherein the duration parameter comprises at least one of: an injection time, the pressure at the pump, the flow rate at the pump, the pressure in the receiving vessel, the pressure in the targeted tissue, the image property, the tissue stretch property, the tissue conductivity, the tissue ultrasound property, the flow rate in the targeted tissue, the fluid cell count, the fluid particle count, and the density of the measurable tracer, and
wherein the processor is further configured to:
determine that a target value of the duration parameter has been met; and
control the pump to distribute the fluid to the targeted tissue based on a second predetermined value of a second controlled parameter in accordance with the second phase of the injection protocol.

6. The system of claim 5 , wherein the second controlled parameter is equal to or different than the first controlled parameter.

7. The system of claim 1 , wherein controlling the pump to distribute the fluid to the targeted tissue comprises controlling the pump to distribute the fluid to the targeted tissue at a pressure of about 10 psi to about 2000 psi.

8. The system of claim 1 , wherein the processor is further configured to:
generate an alert to a user in response to determining that the first limiting parameter is outside the acceptable range; and
control the pump to halt the injection protocol in response to not receiving from the user a response to the alert.

9. A computer-implemented method for automatically delivering a fluid to a targeted tissue in accordance with an injection protocol having at least two phases, the method comprising:
controlling, by a processor, a pump to distribute the fluid to the targeted tissue based on a first predetermined value of a first controlled parameter in accordance with each of a first phase and a second phase of the injection protocol;
receiving, by the processor during each of the first phase and the second phase, one or more signals from a sensing system corresponding to a first limiting parameter, wherein the first limiting parameter comprises at least one of: a pressure at the pump, a flow rate at the pump, a pressure in a receiving vessel, a pressure in the targeted tissue, an image property, a tissue stretch property, a tissue conductivity, a tissue ultrasound property, a flow rate in the targeted tissue, a fluid cell count, a fluid particle count, and a density of a measurable tracer;
determining, by the processor during each of the first phase and the second phase, that the first limiting parameter is outside an acceptable range of the first limiting parameter;
determining, by the processor during each of the first phase and the second phase, an adjusted value of the first controlled parameter in response to determining that the first limiting parameter is outside the acceptable range of the first limiting parameter; and
controlling, by the processor during each of the first phase and the second phase, the pump to distribute the fluid to the targeted tissue based on the adjusted value of the first controlled parameter,
wherein the acceptable range of the first limiting parameter is different during the first phase than during the second phase.

10. The computer-implemented method of claim 9 , wherein the first controlled parameter comprises at least one of an injection pressure, an injection flow rate, an injection volume, the pressure in the targeted tissue, and the flow rate in the targeted tissue.

11. The computer-implemented method of claim 9 , wherein the acceptable range of the first limiting parameter is based on at least one of a threshold at which the targeted tissue will be damaged and a mechanical capacity of the pump.

12. The computer-implemented method of claim 9 , further comprising controlling, by the processor, the pump to deliver the fluid to the targeted tissue based on a second predetermined value of a second controlled parameter,
wherein the second controlled parameter is equal to or different than the first controlled parameter.

13. The computer-implemented method of claim 9 , wherein the one or more signals further correspond to a duration parameter, wherein the duration parameter comprises at least one of: an injection time, the pressure at the pump, the flow rate at the pump, the pressure in the receiving vessel, the pressure in the targeted tissue, the image property, the tissue stretch property, the tissue conductivity, the tissue ultrasound property, the flow rate in the targeted tissue, the fluid cell count, the fluid particle count, and the density of the measurable tracer, and
wherein the method further comprises:
determining, by the processor, that a target value of the duration parameter has been met; and
controlling, by the processor, the pump to distribute the fluid to the targeted tissue based on a second predetermined value of a second controlled parameter in accordance with the second phase of the injection protocol.

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Assignees

• Bayer Healthcare Llc

Inventors

• Uber Iii Arthur
• Yanniello Michael
• Tucker Barry
• Mishler David
• Rhinehart Edward
• Trocki Mark
• Uram Martin
• Brosovich John

Classifications

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61M2205/52

  with memories providing a history of measured variating parameters of apparatus or patient · CPC title

• A61M5/14566

  with a replaceable reservoir for receiving a piston rod of the pump · CPC title

• A61M5/1723 Primary

  using feedback of body parameters, e.g. blood-sugar, pressure (measurement of body parameters A61B5/00) · CPC title

• A61M2205/3576

  with non implanted data transmission devices, e.g. using external transmitter or receiver · CPC title