Microelectrode assembly for monitoring of in vivo neurotransmitters

Patent metadata

Field	Value
Publication number	US-11647927-B2
Application number	US-201816758138-A
Country	US
Kind code	B2
Filing date	Dec 11, 2018
Priority date	Dec 13, 2017
Publication date	May 16, 2023
Grant date	May 16, 2023

Abstract

A microelectrode assembly for in vivo neurotransmitter monitoring according to one embodiment of the present disclosure includes: a microelectrode part formed of a single strand; and a polymer coating layer surrounding the microelectrode part, wherein a portion of the microelectrode part may protrude from the polymer coating layer, neurotransmitters in vivo may be sensed by the protruding portion of the microelectrode part, and plasmonic nanostructures may be formed on the surface of the microelectrode part.

First claim

What is claimed is:

1. A microelectrode assembly for in vivo neurotransmitter monitoring, the microelectrode assembly comprising:
a microelectrode part comprising a single strand; and
a polymer coating layer surrounding the microelectrode part,
wherein the microelectrode part comprises a protruding portion that protrudes from the polymer coating layer,
the protruding portion of the microelectrode part is configured to sense neurotransmitters in vivo,
plasmonic nanostructures are on a surface of the microelectrode part, and
wherein the plasmonic nanostructures comprise an alloy comprising one or more of gold, silver, platinum, palladium, and aluminum.

2. The microelectrode assembly of claim 1 , wherein the microelectrode part is fabricated using carbon fiber so as to have predetermined diameter and protrusion length values.

3. The microelectrode assembly of claim 1 , wherein the microelectrode part is bonded to a silica tube, processed into a predetermined shape, by heat treatment of polyamic acid, and is configured to be bonded to a wire using an electrically conductive material.

4. The microelectrode assembly of claim 1 , wherein the polymer coating layer is a membrane formed by surrounding and coating the microelectrode part excluding the protruding portion with polyimide so as to be insulated.

5. The microelectrode assembly of claim 1 , wherein the plasmonic nanostructures are formed by a predetermined method, and wherein the predetermined method comprises one or more of chemical synthesis, thermal deposition, electron beam evaporation, and sputtering deposition.

6. The microelectrode assembly of claim 1 , wherein the microelectrode assembly is configured to be bonded to a ferrule for optical fiber, and the ferrule is configured to be used as a guide structure for depositing a metal thin layer on the microelectrode part.

Assignees

• Samsung Life Public Welfare Foundation

Inventors

• Kang Min Hee
• Park Eun Kyoung
• Kwon Soon Young
• Lee Kyu Sung

Classifications

• A61B5/263 Primary

  characterised by the electrode materials · CPC title

• A61B5/24 Primary

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• G01N27/3272

  Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels (optical biosensors G01N33/52) · CPC title

• A61B2562/0215

  Silver or silver chloride containing · CPC title

• G01N27/3278 Primary

  involving nanosized elements, e.g. nanogaps or nanoparticles (nanopores G01N33/48721; magnetic beads G01N27/745) · CPC title