Magnetic particle and method

Patent metadata

Field	Value
Publication number	US-11640865-B2
Application number	US-201917291563-A
Country	US
Kind code	B2
Filing date	Nov 11, 2019
Priority date	Nov 12, 2018
Publication date	May 2, 2023
Grant date	May 2, 2023

Abstract

A magnetic particle (30, 70) has a layered structure (6, 56) between a top surface of the particle and an opposed bottom surface of the particle. Layers of the structure include one or more nonmagnetic layer(s) and one or more magnetized layer(s). The ratio of a lateral dimension of the one or more magnetized layers to the aggregate thickness of the magnetized layer or layers is greater than 500. A plurality of such magnetic particles (30, 70) can be functionalised and marked with readable codes (16, 66) corresponding to the functionalisation, for use for performing assays such as bioassays.

First claim

The invention claimed is:

1. A non-agglomerating magnetic particle, comprising a layered structure between a top surface of the non-agglomerating magnetic particle and an opposed bottom surface of the non-agglomerating magnetic particle, the layers including one or more magnetized layers;
in which the ratio of a lateral dimension of the one or more magnetized layers to a thickness or aggregate thickness of the magnetized layer or layers is greater than 500; and
in which the magnetized layer or layers comprise a volume V of magnetic material having a magnetisation or average magnetisation MS, a cross section of the layer or layers has an aspect ratio AR, and AR/Ms 2 (with Ms measured in A/m) is greater than 8×10 −10 (A/m) −2 .

2. A non agglomerating magnetic particle according to claim 1 , in which the ratio of the lateral dimension of the one or more magnetized layers to the thickness or aggregate thickness of the magnetized layer or layers is greater than 1000.

3. A non-agglomerating magnetic particle according to claim 1 , in which the magnetized layer or layers comprise a volume V of magnetic material having a magnetisation or average magnetisation Ms, a cross section of the layer or layers has an aspect ratio AR, and in which AR/Ms (with Ms measured in A/m) is greater than 0.001 (A/m) −1 .

4. A non-agglomerating magnetic particle according to claim 1 , in which the top and bottom surfaces of the non-agglomerating magnetic particle are separated by a particle thickness of between 5 nm and 200 μm.

5. A non-agglomerating magnetic particle according to claim 1 , in which a ratio of the minimum lateral dimension of the non-agglomerating magnetic particle to the thickness of the non-agglomerating magnetic particle is greater than 10.

6. A non-agglomerating magnetic particle according to claim 1 , in which a maximum lateral dimension of the non-agglomerating magnetic particle is less than 1000 μm.

7. A non-agglomerating magnetic particle according to claim 6 , in which the minimum lateral dimension of the non-agglomerating magnetic particle is at least 10% of the maximum lateral dimension of the non-agglomerating magnetic particle.

8. A non-agglomerating magnetic particle according to claim 1 , in which a lateral periphery of the non-agglomerating magnetic particle is of a shape comprising convex or straight sides.

9. A non-agglomerating magnetic particle according to claim 1 , in which the lateral dimensions of the magnetic layer or at least one of the magnetic layers are the same as the lateral dimensions of the non-agglomerating magnetic particle.

10. A non-agglomerating magnetic particle according to claim 1 , in which the magnetized layer or each of the magnetized layers is an out-of-plane-magnetized layer.

11. A non-agglomerating magnetic particle according to claim 1 , in which the magnetized layer or each of the magnetized layers is an in-plane-magnetized layer.

12. A non-agglomerating magnetic particle according to claim 1 , in which the magnetized layer or each of the magnetized layers is positioned between a layer of a non-magnetic material and a second layer of a non-magnetic material.

13. A non-agglomerating magnetic particle according to claim 12 , in which the magnetized layer or each of the magnetized layers is spaced from the top surface of the non-agglomerating magnetic particle by more than 25% of the particle thickness, and is spaced from the bottom surface of the non-agglomerating magnetic particle by more than 25% of the particle thickness.

14. A non-agglomerating magnetic particle according to claim 1 , in which the magnetized layer or each of the magnetized layers has a thickness greater than 0.1 nm.

15. A non-agglomerating magnetic particle according to claim 1 , in which the aggregate thickness of the magnetized layer or layers is less than 25% of the thickness of the non-agglomerating magnetic particle.

16. A non-agglomerating magnetic particle according to claim 1 , in which the magnetized layer or each of the magnetized layers is a thin-film multilayer.

17. A non-agglomerating magnetic particle according to claim 1 , in which the net magnetic field (the stray field) averaged across the top or bottom surface of the non-agglomerating magnetic particle is less than 2500 A/m.

18. A non-agglomerating magnetic particle according to claim 1 , in which the non-agglomerating magnetic particle carries readable information which is readable at or from one or both of the top or bottom surface of the non-agglomerating magnetic particle.

19. A non-agglomerating magnetic particle according to claim 18 , in which a surface of the non-agglomerating magnetic particle is functionalised, and in which the readable information corresponds to the functionality of that non-agglomerating magnetic particle.

20. A method for performing an assay, comprising providing the non-agglomerating magnetic particle as defined in claim 19 to a liquid assay sample, allowing the functionality of the non-agglomerating magnetic particle to interact with the assay sample, applying a magnetic field to steer the non-agglomerating magnetic particle to a reading position, and obtaining an assay result by reading the readable information and the interaction of the functionality of the non-agglomerating magnetic particle with the assay sample.

21. A non-agglomerating magnetic particle according to claim 17 , in which the net magnetic field (the stray field) averaged across the top or bottom surface of the non-agglomerating magnetic particle is less than 800 A/m.

Assignees

• Cambridge Entpr Ltd

Inventors

• Verheyen Jeroen
• Vemulkar Tarun
• Cowburn Russell

Classifications

• H01F10/265 Primary

  Magnetic multilayers non exchange-coupled (H01F10/32 takes precedence) · CPC title

• H01F41/34

  in patterns, e.g. by lithography · CPC title

• G01N33/54326

  Magnetic particles · CPC title