Method for large scale fabrication of Janus/amphiphilic particles using polymer precipitation procedure

Patent metadata

Field	Value
Publication number	US-11639442-B2
Application number	US-201816767601-A
Country	US
Kind code	B2
Filing date	Nov 29, 2018
Priority date	Nov 29, 2017
Publication date	May 2, 2023
Grant date	May 2, 2023

Abstract

This invention provides a method for creating a large-scale of amphiphilic particles. The method includes: adding nanoparticles into a polycarbonate-based solution, adding a surfactant into the solution while performing ultra-sonication to generate polymer precipitation, creating at least one microsphere with the nanoparticles embedded onto it, subjecting the exposed hemisphere of the embedded nanoparticles to a further amphiphilic particles related modification, and dissolving the at least one microsphere in a polycarbonate-based solution in order to free said embedded nanoparticles from the at least one microsphere.

First claim

The invention claimed is:

1. A method for creating large scale of amphiphilic particles comprising:
adding nanoparticles into a polycarbonate-based solution including a solvent;
adding a surfactant into said solution while performing ultrasonication to generate polymer precipitation, said polymer precipitation is configured for creating at least one microsphere with said nanoparticles embedded onto it, said nanoparticles are embedded such that one of their hemispheres is exposed for further modification; and
subjecting said exposed hemisphere of said embedded nanoparticles to a further amphiphilic particles related modification; and
separating said amphiphilic modified embedded nanoparticles by dissolving the polycarbonate from said at least one microsphere using the solvent.

2. The method of claim 1 additionally comprising: filtering said at least one microsphere using centrifugation, rinsing said at least one microsphere with deionized water and drying said at least one microsphere under vacuum before subjecting said exposed hemisphere of said embedded nanoparticles to a further amphiphilic particles related modification.

3. The method of claim 1 , wherein the solvent in said polycarbonate-based solution includes tetrahydrofuran (THF).

4. The method of claim 1 wherein, said nanoparticles are polymethylsilsesquioxane (PMSQ) nanoparticles.

5. The method of claim 1 wherein, said nanoparticles are silica nanoparticles.

6. The method of claim 1 wherein, said surfactant is Dimethyl didodecyl ammonium bromide (DDAB) in water.

7. The method of claim 1 wherein, said further amphiphilic particles related modification is selected from the group consisting of: forming amine groups onto the exposed hemispheres, forming carboxyl groups onto the exposed hemispheres, coupling of amine functionalized silica nanoparticles to a PMSQ-COOH amphiphilic Janus particles.

Assignees

• The State Of Israel Ministry Of Agriculture & Rural Development Agricultural Res Organization

Inventors

• Mechrez Guy
• Ananth Karthik

Classifications

• C08J2383/04

  Polysiloxanes · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• C09C1/28 Primary

  Compounds of silicon {(C09C1/0009, C09C1/0015, C09C1/0078 take precedence)} · CPC title

• C09C1/309

  Combinations of treatments provided for in groups C09C1/3009 - C09C1/3081 · CPC title

• C08J7/12

  Chemical modification · CPC title