Porous optical fiber for the detection of an analyte in a fluid

Patent metadata

Field	Value
Publication number	US-11638544-B2
Application number	US-201816613466-A
Country	US
Kind code	B2
Filing date	May 15, 2018
Priority date	May 17, 2017
Publication date	May 2, 2023
Grant date	May 2, 2023

Abstract

The invention relates to a porous optical fiber for the detection of an analyte in a fluid by optical probing. The optical fiber has a first end and a second end opposite to the first end, as seen in a longitudinal direction, and a circumferential surface delimiting the optical fiber in radial directions perpendicular to the longitudinal direction. The optical fiber comprises a core adapted for supporting at least one optical mode propagating in the longitudinal direction, the core having a circumferential interface delimiting the core in the radial directions. The optical fiber further comprises pores penetrating from an opening at the circumferential surface through the circumferential interface into the core of the optical fiber, wherein a cross-sectional dimension of the openings is dimensioned so as to prevent a particulate fraction of the fluid from entering the pores, while allowing the analyte to enter the pores.

First claim

The invention claimed is:

1. A porous optical fiber for the detection of an analyte in a fluid by optical probing, the optical fiber having a first end and a second end opposite to the first end, as seen in a longitudinal direction, and a circumferential surface delimiting the optical fiber in radial directions perpendicular to the longitudinal direction,
the optical fiber comprising:
a core supporting at least one optical mode propagating in the longitudinal direction, the core having a circumferential interface delimiting the core in the radial directions;
pores penetrating from an opening at the circumferential surface through the circumferential interface into the core of the optical fiber, wherein a cross-sectional dimension of the openings is dimensioned so as to prevent a particulate fraction of the fluid from entering the pores, while allowing the analyte to enter the pores; and

a reflective coating on the circumferential surface.

2. The optical fiber according to claim 1 , wherein the pores are dead-end pores.

3. The optical fiber according to claim 1 , wherein the pores are distributed in the longitudinal direction over an active section of length L.

4. The optical fiber according to claim 1 , wherein the core has a diameter, wherein a depth of penetration of the pores into the core is at least 5% of the diameter of the core.

5. The optical fiber according to claim 1 , wherein a cross-sectional dimension of the openings of the pores is about 1 μm or less.

6. The optical fiber according to claim 1 , wherein a cross-sectional dimension of the openings of the pores is at least 200 nm.

7. The optical fiber according to claim 1 , wherein a length of the pores in an axial direction along the pores is less than 100 μm.

8. The optical fiber according to claim 1 , wherein a length of the pores in an axial direction along the pores is at least 1 μm.

9. The optical fiber according to claim 1 , wherein the pores are straight.

10. The optical fiber according to claim 1 , wherein the pores are track-etched pores formed by exposing the optical fiber to a directional ion bombardment followed by chemical etching.

11. The optical fiber according to claim 1 , wherein an inner wall surface of the pores is coated with a hydrophilic coating.

12. The optical fiber according to claim 1 , wherein the optical fiber is a polymer optical fiber.

13. The optical fiber according to claim 1 , wherein the optical fiber is a multimode optical fiber with a core supporting a plurality of modes propagating in the longitudinal direction.

14. The optical fiber according to claim 1 , wherein the core has a diameter in the range between 5 μm and 500 μm.

15. The optical fiber according to claim 1 , wherein the circumferential interface of the core forms the circumferential surface.

16. The optical fiber according to claim 1 , wherein the circumferential interface of the core is for contacting the fluid to be analyzed.

17. A sensor system for the detection of an analyte in a fluid by optical probing, the sensor comprising a porous optical fiber according to claim 1 ; a light source coupled to the first end for injecting input light into the optical fiber; and a detector arranged to receive output light emitted from the pores in response to illumination by the injected input light.

18. The system according to claim 17 , wherein the detector is arranged in-line in a forward scattering configuration at the second end of the optical fiber.

19. The system according to claim 17 , wherein the detector is arranged in-line in a back-scattering configuration at the first end of the optical fiber.

20. The system according to claim 17 , wherein the detector is arranged off-axis in an outward scattering configuration.

21. The system according to claim 17 , further comprising a sample chamber for receiving a fluid sample to be analyzed, the sample chamber enclosing the active section of the porous optical fiber.

Assignees

• Radiometer Medical Aps

Inventors

• Strange Christian
• Kjaer Thomas

Classifications

• G01N15/1434

  Optical arrangements · CPC title

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• A61B5/1455 Primary

  using optical sensors, e.g. spectral photometrical oximeters · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• G01N21/62

  Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light · CPC title