Contrast-amplifying carriers using a two-dimensional material

Patent metadata

Field	Value
Publication number	US-11635367-B2
Application number	US-201616063652-A
Country	US
Kind code	B2
Filing date	Dec 16, 2016
Priority date	Dec 17, 2015
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength λ through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index n 3 of which is lower than that of the refractive index n 0 of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided.

First claim

The invention claimed is:

1. A contrast-amplifying carrier for observing a sample, comprising a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating suppressing reflection through destructive interference when it is illuminated at normal incidence at an illumination wavelength λ through said substrate and when the face of said coating opposite said substrate is in contact with a transparent ambient medium, a refractive index n 3 of which is lower than that of a refractive index n 0 of said substrate, wherein said absorbent coating comprises:
a contrast sublayer that is absorbent at said illumination wavelength λ and which exhibits an antireflection behavior at said wavelength, deposited on a surface of said transparent substrate; and
an absorbent layer, being a sensitive layer, distinct from said contrast sublayer and comprising between 1 and 5 sheets of at least one two-dimensional material,
each sheet having a monoatomic or mono-molecular thickness,
wherein, a thickness e 1 of the contrast sublayer is expressed as a dimensionless parameter δ 1 which equals 2πn 0 *e 1 /λ, for said illumination wavelength λ, and for said refractive index n 0 of the substrate, said contrast sublayer having a complex index of refraction N 1 =n 1 −jk 1 , having a real part n 1 and an imaginary part k 1 ,
the thickness e 1 of the contrast sublayer is a first thickness wherein dimensionless parameter δ 1 meets the following conditions:

δ
1

≅

(

n
0

n
3

-
1

)

2
⁢

v
1

⁢

κ
1

[

1
-

e

-

κ
1

K

]

where:

v
1

=

n
1

n
0

⁢

n
3

;

⁢

κ
1

=

k
1

n
0

⁢

n
3

;
and

⁢

K
=

{

[

π
/

(

n
0

/

n
3

-
1

)

]

⁢

n
0

/

n
3

}

-
1

,

or the thickness e 1 of the contrast sublayer is less than said first thickness, where:
ν 1 2 ≠1+κ 1 2 .

2. The contrast-amplifying carrier as claimed in claim 1 , wherein said contrast sublayer is chosen from:
a layer of impurities implanted into said substrate;
a metal layer or made of gold;
a semiconductor layer;
a metal/semiconductor composite alloy;
a magnetic absorbent layer;
a layer of metal nanoparticles;
a nonmetal conductive layer;
a scattering layer;
a polymer or photoresist layer containing pigments or dyes;
an inorganic dielectric layer containing color centers;
a composite hybrid layer comprising a continuous phase throughout which nanoparticles are dispersed; and
a multilayer structure.

3. The contrast-amplifying carrier as claimed in claim 1 , wherein said at least one two-dimensional material is a graphene-type material.

4. The contrast-amplifying carrier as claimed in claim 3 , wherein said sensitive layer is chosen from:
a single sheet of a graphene-type material;
a stack of 2 to 5 sheets of at least one graphene-type material;
a single sheet or a stack of 2 to 5 sheets of at least one surface-functionalized graphene-type of material; and
a stack of 2 to 5 sheets of at least one graphene-type material, at least one of which is functionalized on both faces.

5. The contrast-amplifying carrier as claimed in claim 3 , wherein the graphene-type material of said sensitive layer is chosen from:
raw graphene;
graphene oxide;
reduced graphene oxide; and
doped graphene.

6. The contrast-amplifying carr

Assignees

• Commissariat Energie Atomique
• Centre Nat Rech Scient
• Univ Du Mans

Inventors

• Campidelli Stéphane
• Cornut Renaud
• Derycke Vincent
• Ausserre Dominique
• Ausserre Manuel

Classifications

• G01N21/554

  detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance · CPC title

• G02B1/11

  Anti-reflection coatings · CPC title

• G01N21/658

  enhancement Raman, e.g. surface plasmons · CPC title

• G01N21/6428

  Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" (in vivo A61B5/00; immunoassay G01N33/53) · CPC title

• G01N33/54373

  involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings · CPC title