Kinase inhibitors
US-2015329523-A1 · Nov 19, 2015 · US
US11634406B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11634406-B2 |
| Application number | US-202017031190-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 24, 2020 |
| Priority date | Feb 14, 2014 |
| Publication date | Apr 25, 2023 |
| Grant date | Apr 25, 2023 |
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A compound has the following formula:The compound is a p38 MAP kinase inhibitor. The compound and its pharmaceutically acceptable salts can be used for treatment of conditions, such as inflammatory diseases.
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What is claimed is: 1. A method of treatment of a condition selected from exacerbation of COPD and exacerbation of asthma comprising administering to a subject in need thereof an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers thereof. 2. The method of claim 1 , wherein the exacerbation of COPD or exacerbation of asthma is a virally induced exacerbation. 3. The method of claim 1 , wherein the condition is exacerbation of COPD. 4. The method of claim 1 , wherein the COPD is selected from a group consisting of chronic bronchitis and emphysema. 5. The method of claim 1 , wherein the asthma is pediatric asthma. 6. The method of claim 1 , wherein the compound of formula (I) or a pharmaceutically acceptable salt thereof, including all stereoisomers and tautomers thereof is administered as a dry-powder formulation for inhalation. 7. The method of claim 6 , wherein the dry-powder formulation for inhalation comprises lactose. 8. The method of claim 1 , further comprising administering an antiviral agent. 9. The method of claim 1 , wherein the compound of formula (I) is in its free base form. 10. The method of claim 1 , wherein the compound of formula (I) is in anhydrous solid crystalline form.
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