Dosimetry systems for radiation treatment using radiation-detector-triggered cameras to image Cherenkov emissions or thin-sheet scintillators

Patent metadata

Field	Value
Publication number	US-11633627-B2
Application number	US-202117313838-A
Country	US
Kind code	B2
Filing date	May 6, 2021
Priority date	Feb 22, 2018
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging.

First claim

What is claimed is:

1. A system for dosimetry, comprising:
a radiation source adapted to provide a pulsed radiation beam to a treatment zone;
a thin sheet of scintillator disposed between the radiation source and skin of a subject, the thin sheet of scintillator being in the treatment zone;
a gated camera configured to image the sheet of scintillator;
an image capture and processing machine coupled to receive images from the gated camera; and
a first radiation-detecting triggering unit (RTU) configured to detect scattered radiation from the pulsed radiation beam and coupled to trigger the gated camera based upon detecting the scattered radiation;
wherein the gated camera is configured to capture images of light from the thin sheet of scintillator when triggered by the RTU during a plurality of pulses of the pulsed radiation beam while excluding light received from the thin sheet of scintillator between pulses of the plurality of pulses of the pulsed radiation beam to form a scintillation image.

2. The system of claim 1 wherein the thin sheet of scintillator is a conformal sheet of scintillating material in contact with skin of the subject.

3. The system of claim 1 wherein the image capture and processing machine is configured to subtract a background image from the scintillation image, the background image being obtained by the gated camera at times excluding times of pulses of the pulsed radiation beam.

4. The system of claim 3 further comprising a second RTU, and wherein the gated camera is configured to capture images of light from the thin sheet of scintillator when both the first RTU and the second RTU detect radiation simultaneously.

5. The system of claim 3 wherein the image capture and processing machine further comprises a database containing calibration information associated with individual thin sheets of scintillator, and the image capture and processing machine is configured to correct the scintillation image according to the calibration information.

6. The system of claim 3 further comprising a three-dimensional (3-D) imaging camera and wherein the image capture and processing machine is configured to extract a 3-D surface model of the thin sheet of scintillator and to use the 3-D surface model to correct images received from the gated camera.

7. A system for dosimetry of claim 3 wherein the background image is obtained between pulses of the pulsed radiation beam.

8. A method of dosimetry, comprising:
providing a pulsed radiation beam to a treatment zone;
positioning a thin sheet of scintillator in the treatment zone between the radiation source and skin of a subject;
detecting, with a first radiation-detecting triggering unit (RTU) configured to detect scattered radiation from the pulsed radiation beam, pulses of the pulsed radiation beam; and
using detections of radiation by first RTU to trigger a gated camera to image the sheet of scintillator during pulses of the pulsed radiation beam while excluding light between pulses of the pulsed radiation beam to form a scintillation image; and
wherein the gated camera captures images of light from the thin sheet of scintillator during a plurality of pulses of the pulsed radiation beam.

9. The method of claim 8 wherein the thin sheet of scintillator is a conformal sheet of scintillating material in contact with skin of the subject.

10. The method of claim 8 further comprising subtracting a background image from the scintillation image, the background image being obtained by the gated camera at times between pulses of the pulsed radiation beam.

11. The method of claim 8 further comprising:
using a second RTU in combination with the first RTU, and wherein the gated camera is used to capture images of light from the thin sheet of scintillator when both the first RTU and the second RTU detect radiation simultaneously.

Assignees

• Dartmouth College
• Doseoptics Llc

Inventors

• Krishnaswamy Venkataramanan
• Bruza Jr Petr
• Jermyn Michael
• Pogue Brian W
• Gladstone David
• Jarvis Lesley A
• Tendler Irwin

Classifications

• A61B5/0077

  Devices for viewing the surface of the body, e.g. camera, magnifying lens · CPC title

• A61N5/1081

  Rotating beam systems with a specific mechanical construction, e.g. gantries · CPC title

• A61N2005/1054

  using a portal imaging system · CPC title

• A61N5/1049

  for verifying the position of the patient with respect to the radiation beam · CPC title

• G01T1/22

  with Cerenkov detectors · CPC title