Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines

Patent metadata

Field	Value
Publication number	US-11633608-B2
Application number	US-202117170677-A
Country	US
Kind code	B2
Filing date	Feb 8, 2021
Priority date	Aug 28, 2012
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.

First claim

What is claimed is:

1. A system for facilitating a selection of electrical stimulation parameters for stimulating patient tissue, the system comprising:
a processor configured for:
iteratively performing the following for each of a plurality of values of a particular stimulation parameter, each of the values corresponding to a respective electric field:
positioning, by the processor, the electric field at each of a plurality of locations about a leadwire;
directing stimulation of the patient tissue using the leadwire at each of the locations with the electric field; and
for each of the locations, obtaining, by the processor, clinical effect information regarding the stimulation of the patient tissue produced by the electric field at the location, wherein the obtained clinical effect information includes at least one therapeutic effect value or adverse side effect value; and

based on the obtained clinical effect information, identifying a combination of a selected value for the particular stimulation parameter and a selected location about the leadwire at which to perform stimulation using the selected value, wherein the identifying comprises, within a graph that plots the therapeutic effect values and the adverse side effect values for the values of the particular stimulation parameter and the locations about the leadwire, identifying a region of the graph in which a lowest value of the particular stimulation parameter that achieves a therapeutic effect is lower than a lowest value of the particular stimulation parameter that causes an adverse side effect and identifying the combination in the region.

2. The system of claim 1 , wherein identifying the combination in the region comprises identifying the combination with a greatest difference between the lowest value of the particular stimulation parameter that achieves the therapeutic effect and the lowest value of the particular stimulation parameter that causes the adverse side effect.

3. The system of claim 1 , wherein the graph is three dimensional.

4. The system of claim 3 , wherein the graph further plots the obtained clinical effect information against values for a second stimulation parameter.

5. The system of claim 1 , wherein the locations are distributed both longitudinally and rotationally about the leadwire.

6. The system of claim 1 , wherein the processor is further configured for:
receiving user input of a point within the graph, the user input provided by pointing and selecting within the graph; and
determining, by the processor, values for the particular stimulation parameter for each of a plurality of electrodes of the leadwire at the point.

7. The system of claim 1 , wherein each of the locations corresponds to a selection of one or more electrodes of the leadwire to produce the electric field.

8. The system of claim 1 , wherein the positioning comprises shifting the electric field longitudinally, rotationally, or both longitudinally and rotationally along the leadwire.

9. A method for selecting stimulation parameters for a leadwire implanted in patient tissue, the method comprising:
for each of a plurality of values for a particular stimulation parameter, each of the values corresponding to a respective electric field, obtaining, by a processor, clinical effect information regarding a stimulation of the patient tissue produced by the respective electric field at each of a plurality of locations about the leadwire;
displaying a graph plotting the obtained clinical effect information against the values for the particular stimulation parameter and the locations about the leadwire;
receiving a user selection of a point on the graph, wherein the point corresponds to a first value of the particular stimulation parameter and a first location about the leadwire;
programming an implantable pulse generator with the first value of the particular stimulation parameter and a selection of one or more electrodes on the leadwire corresponding to the first location about the leadwire to produce electrical stimulation; and
stimulating the patient tissue using the first value of the particular stimulation parameter and the selection of one or more electrodes on the leadwire corresponding to the first location about the leadwire.

10. The method of claim 9 , wherein the locations differ longitudinally and rotationally about the leadwire.

11. The method of claim 9 , wherein the particular stimulation parameter is one of i) amplitude, ii) pulse width, or iii) frequency.

12. The method of claim 9 , wherein the obtained clinical effect information includes therapeutic effect values and adverse side effect values.

13. The method of claim 12 , further comprising identifying within the graph, a region in which a lowest value of the particular stimulation parameter that achieves a therapeutic effect is lower than a lowest value of the particular stimulation parameter that causes an adverse side effect.

14. The method of claim 13 , further comprising identifying, in the region, a combination of a selected value for the particular stimulation parameter and a selected location about the leadwire at which to perform a stimulation using the selected value in the region, wherein the combination has a greatest difference between the lowest value of the particular stimulation parameter that achieves the therapeutic effect and the lowest value of the particular stimulation parameter that causes the adverse side effect.

15. A method for selecting stimulation parameters for a leadwire implanted in patient tissue and comprising a plurality of electrodes, wherein the plurality of electrodes comprises at least one set of two or more directional electrodes, wherein the directional electrodes of each set are disposed at a same longitudinal level of the leadwire but at different circumferential positions, the method comprising:
for each of a plurality of values for a particular stimulation parameter, each of the values corresponding to a respective electric field produced by a combination of one or more electrodes of the leadwire, obtaining, by a processor, clinical effect information regarding stimulation of the patient tissue produced by the respective electric field;
displaying a graph plotting the obtained clinical effect information as data points, wherein each data point is characterized by an angle of rotation and a radius from a center of the graph, wherein the radius corresponds to the value for the particular stimulation parameter for the data point and the angle of rotation corresponds to a direction characterizing the electric field for the data point;
receiving a user selection of a point on the graph, wherein the point corresponds to a first value of the particular stimulation parameter and a first set of one or more electrodes of the leadwire;
initiating a signal, by the computer processor, to program an implantable pulse generator with the first value of the particular stimulation parameter and the first set of one or more electrodes on the leadwire to produce a stimulation; and
stimulating the patient tissue using the first value of the particular stimulation parameter and the first set of one or more electrodes on the leadwire.

16. The method of claim 15 , wherein the particular stimulation parameter is one of i) amplitude, ii) pulse width, or iii) frequency.

17. The method of claim 15 , wherein the obtained clinical effect information includes therapeutic effect values and adverse side effect values.

18. The method of claim 17 , further comprising identifying within the graph, a region in which a lowest

Assignees

• Boston Scient Neuromodulation Corp

Inventors

• Carcieri Stephen
• Chen Dean
• Moffitt Michael A

Classifications

• A61N1/3605

  Implantable neurostimulators for stimulating central or peripheral nerve system · CPC title

• A61N1/37247 Primary

  User interfaces, e.g. input or presentation means · CPC title

• G16H40/63

  for local operation · CPC title

• A61N1/0534

  Electrodes for deep brain stimulation · CPC title

• G16Z99/00

  Subject matter not provided for in other main groups of this subclass · CPC title