HER2 binders
US-10894097-B2 · Jan 19, 2021 · US
HER2 binders
US11633507B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11633507-B2 |
| Application number | US-202017117697-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 10, 2020 |
| Priority date | Dec 22, 2010 |
| Publication date | Apr 25, 2023 |
| Grant date | Apr 25, 2023 |
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- Title
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- Abstract
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Abstract
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Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
First claim
Opening claim text (preview).
The invention claimed is: 1. An imaging compound comprising: an isolated polypeptide and an 18 F radioisotope coupled to the polypeptide through a bifunctional linker molecule, wherein the radioisotope is coupled to the bifunctional linker via an aminoxy group, an azido group, or an alkyne group, wherein the isolated polypeptide comprises SEQ ID No: 1 or SEQ ID No: 2, and wherein the isolated polypeptide binds specifically to HER2. 2. The compound of claim 1 , wherein the 18 F radioisotope is coupled to the bifunctional linker via an aminoxy group. 3. The compound of claim 2 , wherein the 18 F radioisotope is coupled to the aminoxy group through an 18 F-fluorobenzaldehyde group. 4. The compound of claim 1 , wherein the bifunctional aminoxy linker is a tert-butyl 2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylamino)-2-oxoethoxycarbamate linker. 5. The compound of claim 1 , wherein the radioisotope is conjugated to the isolated polypeptide via the bifunctional aminoxy linker at the N-terminus of the isolated polypeptide. 6. An imaging compound comprising: an isolated polypeptide comprising SEQ ID No: 2 conjugated with a 18 F radioisotope via a tert-butyl 2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylamino)-2-oxoethoxycarbamate linker, wherein the isolated polypeptide binds specifically to HER2. 7. The method of claim 6 , wherein the 18 F radioisotope is coupled to the bifunctional linker via an aminoxy group. 8. The method of claim 6 , wherein the 18 F radioisotope is coupled to the aminoxy group through an 18 F-fluorobenzaldehyde group.
Assignees
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Classifications
for growth factors; for growth regulators · CPC title
- A61K51/088Primary
conjugates with carriers being peptides, polyamino acids or proteins (antibodies A61K51/10) · CPC title
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Frequently asked questions
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- What does patent US11633507B2 cover?
- Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
- Who is the assignee on this patent?
- Gen Electric, Affibody Ab
- What technology area does this patent fall under?
- Primary CPC classification A61K51/088. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).