Compositions and methods for treating vaginal dryness

Patent metadata

Field	Value
Publication number	US-11633452-B2
Application number	US-202017080930-A
Country	US
Kind code	B2
Filing date	Oct 27, 2020
Priority date	May 4, 2018
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.

First claim

What is claimed is:

1. A method of treating vaginal dryness, comprising:
administering a vaginal care composition to vaginal tissue of a user experiencing vaginal dryness, wherein the vaginal care composition comprises spherical particles having a mean particle size of about 2 microns to about 40 microns and selected from the group consisting of spherical starch particles, spherical silicone elastomer particles, and mixtures thereof, and an effective amount of a vaginal care agent selected from disodium tetramethylhexadecenyl succinyl cysteine, Castanea sativa, Myrocarpus frondosus, Myrocarpus fastigiatus, Pistacia lentiscus gum oil, glyceryl monoricinoleate, pentapeptide-28, Cinnamomum cassia , bamboo, Paeonia suffruticosa , hydroxydecyl ubiquinone, myristoyl octapeptide-1, hydrolyzed soybean fiber, yeast extract, hexapeptide-9, geranyllinalool, Gelidium cartilagineum , menthyl anthranilate, Oenothera biennis , hyaluronic acid, tetrapeptide-21, proanthocyanidin A, arginine aminobenzoate, a mixture of glycolic acid, ascorbyl tetraisopalmitate, and kojic acid, Brassica rapa , farnesene, dehydrocholesterol, javanol, Ballota pseudodictamus , dipropyl-7-methylxanthine, Stachys byzantina, 2-decanone, a mixture of biotin, linoleic acid, vitamin E, panthenol, and caffeine, a mixture of propanediol, lysine, lecithin, phenoxyethanol, tripeptide-9, acetyl tetrapeptide-11, algae extracts, piroctone olamine, citrulline, and derivatives and combinations of these.

2. The method of claim 1 , wherein the vaginal care agent is present at an amount of about 0.0001% to about 15%.

3. The method of claim 1 , wherein the composition is in the form of an oil-in-water emulsion.

4. The method of claim 3 , wherein the oil phase comprises a non-volatile oil selected from non-volatile silicone oil, camelina seed oil, sunflower seed oil, safflower oil and combinations thereof.

5. The method of claim 4 , wherein the spherical particles are spherical silicone elastomer particles and wherein the ratio of non-volatile oil to silicone elastomer particles is about 1:10 to about 3:2.

6. The method of claim 1 , wherein the vaginal care composition comprises a humectant.

7. The method of claim 1 , wherein the vaginal care composition comprises about 0.1% to about 20% by weight of a silicone elastomer.

8. The method of claim 1 , wherein the vaginal care composition is substantially free of vaginal irritants selected from retinoids, ethanol, sunscreen agents, perfumes, estrogen, progesterone, particulates having an average particle size of greater than about 125 microns, and combinations of these.

9. The method of claim 1 , wherein the vaginal care composition is administered by the user during a treatment period sufficient to improve the symptom of vaginal dryness.

10. The method of claim 9 , wherein the treatment period is at least about 4 weeks.

11. The method of claim 9 , wherein the vaginal care composition is applied at least two times per week during the treatment period.

12. The method of claim 1 , wherein the vaginal care composition is substantially free of a mucoadhesive agent selected from polyacrylates, carbomers, polycarbophils poly(methylvinyl ether/maleic anhydride) copolymers, acidic synthetically modified natural polymers, basic amine-bearing polymers, acidic polymers obtainable from natural sources, and neutral synthetic polymers.

13. A method of treating vaginal dryness, comprising: administering a vaginal care composition to vaginal tissue of a user experiencing vaginal dryness, wherein the vaginal care composition comprises wax particles having a melting point of between about 25° C. and about 37° C. and an effective amount of a vaginal care agent selected from disodium tetramethylhexadecenyl succinyl cysteine, Castanea sativa, Myrocarpus frondosus, Myrocarpus fastigiatus, Pistacia lentiscus gum oil, glyceryl monoricinoleate, pentapeptide-28 , Cinnamomum cassia , bamboo, Paeonia suffruticosa , hydroxydecyl ubiquinone, myristoyl octapeptide-1, hydrolyzed soybean fiber, yeast extract, hexapeptide-9, geranyllinalool, Gelidium cartilagineum , menthyl anthranilate, Oenothera biennis , hyaluronic acid, tetrapeptide-21, proanthocyanidin A, arginine aminobenzoate, a mixture of glycolic acid, ascorbyl tetraisopalmitate, and kojic acid, Brassica rapa , farnesene, dehydrocholesterol, javanol, Ballota pseudodictamus , dipropyl-7-methylxanthine, Stachys byzantina, 2-decanone, a mixture of biotin, linoleic acid, vitamin E, panthenol, and caffeine, a mixture of propanediol, lysine, lecithin, phenoxyethanol, tripeptide-9, acetyl tetrapeptide-11, algae extracts, piroctone olamine, citrulline, and derivatives and combinations of these.

14. A method of treating vaginal dryness, comprising: administering a vaginal care composition to vaginal tissue of a user experiencing vaginal dryness, wherein the vaginal care composition comprises hyaluronic acid or a salt thereof in an amount of about 0.01% to about 10% and a polyacrylamide thickener, wherein the ratio of hyaluronic acid to polyacrylamide thickener is about 1:10 to about 1:1, and an effective amount of a vaginal care agent selected from disodium tetramethylhexadecenyl succinyl cysteine, Castanea sativa, Myrocarpus frondosus, Myrocarpus fastigiatus, Pistacia lentiscus gum oil, glyceryl monoricinoleate, pentapeptide-28 , Cinnamomum cassia , bamboo, Paeonia suffruticosa , hydroxydecyl ubiquinone, myristoyl octapeptide-1, hydrolyzed soybean fiber, yeast extract, hexapeptide-9, geranyllinalool, Gelidium cartilagineum , menthyl anthranilate, Oenothera biennis , hyaluronic acid, tetrapeptide-21, proanthocyanidin A, arginine aminobenzoate, a mixture of glycolic acid, ascorbyl tetraisopalmitate, and kojic acid, Brassica rapa , farnesene, dehydrocholesterol, javanol, Ballota pseudodictamus , dipropyl-7-methylxanthine, Stachys byzantina, 2-decanone, a mixture of biotin, linoleic acid, vitamin E, panthenol, and caffeine, a mixture of propanediol, lysine, lecithin, phenoxyethanol, tripeptide-9, acetyl tetrapeptide-11, algae extracts, piroctone olamine, citrulline, and derivatives and combinations of these.

15. The method of claim 1 , wherein the vaginal care composition is applied with a topical applicator selected from gloves, swabs, wipes, sponges, plunger-style applicators, applicators with a cone-shaped insertion portion, and vaginal rings.

16. The method of claim 13 , wherein the vaginal care composition is applied with a topical applicator selected from gloves, swabs, wipes, sponges, plunger-style applicators, applicators with a cone-shaped insertion portion, and vaginal rings.

17. The method of claim 14 , wherein the vaginal care composition is applied with a topical applicator selected from gloves, swabs, wipes, sponges, plunger-style applicators, applicators with a cone-shaped insertion portion, and vaginal rings.

Assignees

• Procter & Gamble

Inventors

• Hodgdon Travis Kyle
• Laughlin Ii Leo Timothy
• Wang Samantha Chen-Yee
• Binder Robert Lloyd

Classifications

• A61K36/185

  Magnoliopsida (dicotyledons) · CPC title

• A61K31/355

  Tocopherols, e.g. vitamin E · CPC title

• A61K38/08 Primary

  Peptides having 5 to 11 amino acids {(A61K38/043 - A61K38/046 take precedence)} · CPC title

• A61K36/22

  Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak · CPC title

• A61K36/49 Primary

  Fagaceae (Beech family), e.g. oak or chestnut · CPC title