Immunotherapeutic potential of modified lipooligosaccharides/lipid a
US-2019367959-A1 · Dec 5, 2019 · US
Methods of treating sepsis using anti-sepsis lipid A (ASLA) based therapeutics
US11633411B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11633411-B2 |
| Application number | US-201716339313-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 4, 2017 |
| Priority date | Oct 4, 2016 |
| Publication date | Apr 25, 2023 |
| Grant date | Apr 25, 2023 |
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- Title
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- Abstract
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Abstract
Official abstract text for this publication.
The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up to 13 carbons (for a chain of 16 carbons), and R8, R9, R10 and R11 may be H, OH, or an alkyl or alkenyl ester of up to 16 carbons, or a salt thereof.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound having a formula selected from the group consisting of: 2. The compound of claim 1 , wherein the compound has the formula: 3. The compound of claim 1 , wherein the compound has the formula: 4. The compound of claim 1 , wherein the compound has the formula: 5. The compound of claim 1 , wherein the compound has the formula: 6. The compound of claim 1 , wherein the compound has the formula: 7. The compound of claim 1 , wherein the compound has the formula: 8. The compound of claim 1 , wherein the compound has the formula: 9. The compound of claim 1 , wherein the compound has the formula: 10. The compound of claim 1 , wherein the compound has the formula: 11. The compound of claim 1 , wherein the compound has the formula: 12. The compound of claim 1 , wherein the compound has the formula: 13. The compound of claim 1 , wherein the compound has the formula: 14. The compound of claim 1 , wherein the compound has the formula: 15. The compound of claim 1 , wherein the compound has the formula: 16. The compound of claim 1 , wherein the compound has the formula: 17. The compound of claim 1 , wherein the compound has the formula: 18. The compound of claim 1 , wherein the compound has the formula: 19. The compound of claim 1 , wherein the compound has the formula:
Assignees
Inventors
Classifications
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters · CPC title
- C07H13/06Primary
Fatty acids · CPC title
for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites · CPC title
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
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Frequently asked questions
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- What does patent US11633411B2 cover?
- The present invention provides a method of treating sepsis in a subject, comprising administering to the subject an effective amount of a compound of the formula wherein R1 and R2 may be H, OH, protonated phosphate, a phosphate salt, a sugar phosphonate, or a mono-, di- or poly-saccharide, R3 may be OH or a mono-, di- or poly-saccharide, R4, R5, R6 and R7 may be an alkyl or alkenyl chain of up …
- Who is the assignee on this patent?
- Ernst Robert K, Harberts Erin M, Scott Alison J, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07H13/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 25 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).