Method for producing organic material microparticles, and method for modifying organic material microparticles

Patent metadata

Field	Value
Publication number	US-11633359-B2
Application number	US-201515535980-A
Country	US
Kind code	B2
Filing date	Dec 15, 2015
Priority date	Dec 15, 2014
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

Provided are a method for producing organic material microparticles and a method for modifying organic material microparticles, whereby it becomes possible to improve the crystallinity of organic material microparticles or achieve the crystal transformation of the organic material microparticles while preventing the growth of the organic material microparticles in a solvent. A surfactant is added to a solvent that is capable of partially dissolving organic material microparticles, and then the organic material microparticles are reacted with the solvent. In this manner, it becomes possible to improve the degree of crystallization of the organic material microparticles or achieve the crystal transformation of the organic material microparticles without substantially altering the particle diameters of the organic material microparticles.

First claim

The invention claimed is:

1. A method for producing an organic material microparticle, wherein the method comprises:
step 1 in which the organic material microparticle, at least part of the organic material microparticle being composed of an amorphous portion, is separated; and
step 2 in which a particle property control solution having a surfactant added into a solvent, to which a solubility of the organic material microparticle is in the range of 1 to 1000 μg/g at room temperature and indicates such degree of dissolvability so as to cause some change in the properties of the microparticle, is prepared and said organic material microparticle is introduced into the particle property control solution, wherein
the step 2 is introduced into the organic material microparticle separated in the step 1 , to enhance a degree of crystallinity of the organic material microparticle,
wherein, when a particle diameter of the organic material microparticle after the organic material microparticle is introduced into the particle property control solution is (A) and a particle diameter of the organic material microparticle before the organic material microparticle is introduced into the particle property control solution is (B), a ratio of the particle diameter of the organic material microparticle (A)/(B) is in a range of 1.09 to 4.

2. A method for producing an organic material microparticle, wherein the method comprises:
step 1 in which the organic material microparticle, at least part of the organic material microparticle being composed of an amorphous portion, is separated; and
step 2 in which a particle property control solution having a surfactant added into a solvent, to which a solubility of the organic material microparticle is in the range of 1 to 1000 μg/g at room temperature and indicates such degree of dissolvability so as to cause some change in the properties of the microparticle, is prepared and said organic material microparticle is introduced into the particle property control solution, wherein
the step 2 is introduced into the organic material microparticle separated in the step 1 , to effect a crystal transition of the organic material microparticle,
wherein, when a particle diameter of the organic material microparticle after the organic material microparticle is introduced into the particle property control solution is (A) and a particle diameter of the organic material microparticle before the organic material microparticle is introduced into the particle property control solution is (B), a ratio of the particle diameter of the organic material microparticle (A)/(B) is in a range of 1.09 to 4.

3. A method for producing an organic material microparticle, wherein the method comprises:
step 1 in which a raw material solution of the organic material microparticle is mixed with a separating solvent L for separating at least one kind of the organic material particles from the raw material solution of the organic material microparticle thereby effecting separation of an organic material microparticle (P 1 ); and
step 2 in which a particle property control solution having a surfactant, which is capable of suppressing growth of the organic material microparticle, added into a solvent to which a solubility of the organic material microparticle is in the range of 1 to 1000 μg/g at room temperature and indicates such degree of dissolvability so as to cause some change in the properties of the microparticle, is prepared and the said organic material microparticle (P 1 ) is introduced into the particle property control solution, wherein
the step 2 is made to act so as to control particle properties of the organic material microparticle (P 1 ) separated in the step 1 ,
wherein, when a particle diameter of the organic material microparticle after the organic material microparticle is introduced into the particle property control solution is (A) and a particle diameter of the organic material microparticle before the organic material microparticle is introduced into the particle property control solution is (B), a ratio of the particle diameter of the organic material microparticle (A)/(B) is in a range of 1.09 to 4.

4. The method for producing the organic material microparticle according to claim 3 , wherein the step 2 is made to act so as to change at least any one of degree of crystallinity, crystal type, and crystal diameter of the organic material microparticle (P 1 ).

5. The method for producing the organic material microparticle according to claim 3 , wherein the method comprises step c in which the organic material microparticle (P 1 ) obtained in the step 1 is subjected to washing and/or solvent substitution, and an organic material microparticle (P 2 ) obtained in the step c is introduced into the particle property control solution.

6. The method for producing the organic material microparticle according to claim 3 , wherein the organic material microparticle contains an amorphous portion at least in part thereof.

7. The method for producing the organic material microparticle according to claim 1 , wherein at a time when the organic material microparticle is introduced into the particle property control solution, a stirring treatment is conducted so as to control properties of the organic material microparticle by means of a stirring energy.

8. The method for producing the organic material microparticle according to claim 1 , wherein the organic material microparticle is of a biologically ingestible sub stance.

9. The method for producing the organic material microparticle according to claim 1 , wherein the organic material microparticle is of a resin.

10. The method for producing the organic material microparticle according to claim 1 , wherein the organic material microparticle is of an organic pigment.

11. The method for producing the organic material microparticle according to claim 10 , wherein the organic material microparticle is of a red organic pigment or of a blue organic pigment.

12. The method for producing the organic material microparticle according to claim 3 , wherein
the step 1 is conducted in a microreactor in which at least two fluids to be processed, comprising the raw material solution of the organic material microparticle and the separating solvent L, are introduced into between a first processing surface and a second processing surface which are disposed in a position they are faced with each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other;
a separating force which acts in a direction to separate the first processing surface and the second processing surface from each other is generated by an introduction pressure imparted to between the first processing surface and the second processing surface;
with keeping a distance of 1 mm or less between the first processing surface and the second processing surface by the separating force, the at least two fluids to be processed are caused to converge with each other between the first processing surface and the second processing surface that are kept at the distance of 1 mm or less thereby causing to pass the fluids to be processed through between the first processing surface and the second processing surface so as to form a thin film fluid; and
the fluids to be processed are made to react with each other in the thin film fluid.

13. The method for producing the organic material microparticle according to claim 7 , wherein the stirring is conducted by using a stirrer equipped with a rotating and stirring blade.

14. The method for producing the organic material microparticle a

Assignees

• M Technique Co Ltd

Inventors

• Enomura Masakazu
• Araki Kaeko
• Honda Daisuke

Classifications

• A61K9/146 Primary

  with organic macromolecular compounds · CPC title

• A61K31/405

  Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title

• B01J19/0093

  Microreactors, e.g. miniaturised or microfabricated reactors (laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027) · CPC title

• B01J2219/00889

  Mixing · CPC title

• B01J19/00

  Chemical, physical or physico-chemical processes in general; Their relevant apparatus · CPC title