Surface treatment by water-soluble polymers and lipids/liposomes

Patent metadata

Field	Value
Publication number	US-11633358-B2
Application number	US-202117190537-A
Country	US
Kind code	B2
Filing date	Mar 3, 2021
Priority date	Jun 15, 2014
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

First claim

What is claimed is:

1. A method of reducing a friction coefficient of a surface, the method comprising contacting the surface with a solution comprising at least one water-soluble polymer, liposomes, and an aqueous carrier, and modifying the surface so as to obtain a modified surface, wherein said water-soluble polymer and said modified surface are selected such that said water-soluble polymer is attachable to said modified surface.

2. The method of claim 1 , wherein a molar percentage of phosphatidylcholine in said liposomes is at least 50%.

3. The method of claim 1 , wherein said at least one water-soluble polymer comprises a non-ionic polymer.

4. The method of claim 1 , wherein said at least one water-soluble polymer comprises an ionic polymer.

5. The method of claim 1 , wherein said at least one water-soluble polymer comprises a biopolymer.

6. The method of claim 1 , wherein said water-soluble polymer is selected from the group consisting of a hyaluronic acid, a polyvinylpyrrolidone and a polyethylene oxide.

7. The method of claim 1 , wherein said surface is a physiological surface, and said carrier is a physiologically acceptable carrier.

8. The method of claim 7 , wherein said surface is an articular surface of a synovial joint.

9. The method of claim 8 , being for use in the treatment of a synovial joint disorder associated with an increased friction coefficient of an articular surface in the synovial joint.

10. A method of reducing a friction coefficient of a surface, the method comprising:
attaching at least one water-soluble polymer to the surface, wherein said attaching at least one water-soluble polymer to the surface comprises modifying the surface to obtain a modified surface, and said water-soluble polymer is selected to be attachable to said modified surface; and
contacting said at least one water-soluble polymer with liposomes,
thereby effecting coating of the surface by an amphiphilic lipid of said liposomes, wherein said amphiphilic lipid comprises at least one charged group, and wherein at least a portion of molecules of said amphiphilic lipid coating said surface are oriented such that charged groups thereof face outwards at said surface.

11. The method of claim 10 , wherein said attaching at least one water-soluble polymer to the surface is effected prior to said contacting said at least one water-soluble polymer with liposomes.

12. The method of claim 10 , wherein a molar percentage of phosphatidylcholine in said liposomes is at least 50%.

13. The method of claim 10 , wherein said at least one water-soluble polymer comprises a non-ionic polymer.

14. The method of claim 10 , wherein said at least one water-soluble polymer comprises an ionic polymer.

15. The method of claim 10 , wherein said at least one water-soluble polymer comprises a biopolymer.

16. The method of claim 10 , wherein said water-soluble polymer is selected from the group consisting of a hyaluronic acid, a polyvinylpyrrolidone and a polyethylene oxide.

17. The method of claim 10 , wherein said surface is a physiological surface.

18. The method of claim 17 , wherein said surface is an articular surface of a synovial joint.

19. The method of claim 18 , being for use in the treatment of a synovial joint disorder associated with an increased friction coefficient of an articular surface in the synovial joint.

20. An article of manufacture comprising a composition-of-matter, the composition-of-matter comprising a substrate coated, on at least a portion of a surface thereof, by at least one water-soluble polymer, the article of manufacture being identified for use for efficiently attaching thereto an amphiphilic lipid so as to reduce a friction coefficient of said substrate.

Assignees

• Yeda Res & Dev

Inventors

• Klein Jacob
• Goldberg Ronit
• Seror Jasmine
• Lin Weifeng
• Mashiach Reut

Classifications

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K31/79

  Polymers of vinyl pyrrolidone · CPC title

• A61K31/77

  of oxiranes · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title