Filter for the exchange of heat and moisture for application in the medical field and procedure for the production thereof

Patent metadata

Field	Value
Publication number	US-11628602-B2
Application number	US-201816489504-A
Country	US
Kind code	B2
Filing date	Feb 27, 2018
Priority date	Feb 28, 2017
Publication date	Apr 18, 2023
Grant date	Apr 18, 2023

Abstract

Filter made entirely with natural and biodegradable materials, for the protection of the respiratory tract of patients in the medical-surgical field and process for making it. The filter has a porosity or 80-98% and pore diameters of 100-350 micrometers and the pores have a shape of channels open at the ends, which are parallel to each other. The filter is obtained by preparing an aqueous solution of chitosan and an aqueous solution of gelatin, mixing them, pouring it into a container, keeping the container closed until obtaining a hydrogel and freeze-drying. A cross-linking step takes place by (a) adding a chemical cross-linker to the mixture of the chitosan and gelatine solutions and cross-linking before freeze-drying, or (b) subjecting the freeze-drying product to a thermal dehydration treatment.

First claim

The invention claimed is:

1. Process for preparing a material useful for the production of Heat and Moisture Exchange (HME) filters, which comprises the following steps:
a) preparing an acidic aqueous solution of chitosan in a concentration from 1 to 2.5% by weight;
b) preparing an aqueous solution of a gelatin of animal origin in a concentration from 2.5 to 5% by weight, operating at a temperature between 40 and 50° C.;
c) mixing the two solutions from steps a) and b) in such quantities as to obtain a mixture having a weight ratio of gelatin:chitosan from 80:20 to 50:50, gently stirring the mixture to avoid the formation of a foam until obtaining a homogeneous solution, and subsequently diluting the homogeneous solution to obtain a polymer solution having a total polymer concentration of from 2 to 4% by weight;
d) pouring the polymer solution prepared in step c) into a container with the bottom made of a material having thermal conductivity greater than or equal to 15 W/(m·K) and side walls made of a material having thermal conductivity less than or equal to 1 W/(m·K);
e) freeze-drying, inside said container, the polymer solution obtained in step c) according to the following phases:
freezing the polymer solution to a temperature of from −20 to −60° C. by placing the bottom of the container in contact with a refrigerating system;
primary drying by heating with a rate between 2 and 8° C./h up to a temperature between −5 and −10° C., operating at a pressure between 0.001 mbar and atmospheric pressure and;
secondary drying by heating with a rate between 1 and 5° C./h up to a temperature between 15 and 20° C., operating at a pressure between 0.001 mbar and atmospheric pressure; and

f) a crosslinking treatment consisting of a step of subjecting the freeze-dried product obtained in step e) to a thermal dehydration.

2. The process according to claim 1 , wherein the container has the bottom made with steel, copper or silicon, and the walls made with a plastic, teflon or glass.

3. The process according to claim 1 , wherein step f) is carried out with a heat treatment which consists in subjecting the freeze-dried product obtained in step e) to a temperature from 140 to 160° C. at a pressure between 0.001 mbar and the atmospheric pressure and for a duration between 24 and 48 h.

4. The process according to claim 1 , wherein, prior to the pouring of the polymer solution in step d) to serve as a surrounding polymeric material, the same container is introduced a paramagnetic core comprising a hydroxyapatite in which an amount of between 2 and 40 atomic % of calcium is replaced by iron present in both oxidation states (II) and (III), produced by a process which comprises the following steps:
g) preparing an aqueous solution containing a precursor of calcium, at least one soluble salt of iron (II) and at least one soluble salt of iron (III);
h) preparing an aqueous solution containing a water soluble compound of phosphorus;
i) preparing an aqueous solution containing a precursor of one or more hydrophilic polymers;
j) slowly adding the phosphorus compound solution to the solution containing the precursor of calcium and the iron salts, obtaining a suspension;
k) optionally, immediately adding the solution obtained in step i) to the suspension obtained in step j);
l) If step k) has been carried out, allowing the suspension to react at a temperature between ambient T and 70° C. for a time between 1 and 5 hours;
k′) in case steps k) and l) have not been carried out, allowing the system obtained in step j) to react at a temperature between ambient T and 70° C. for a time between 1 and 24 hours; and
l′) if step k′) has been carried out, mixing the suspension obtained with the aqueous solution obtained in step i);
m) subjecting to a freeze-drying treatment of the solution/suspension product obtained in step l) or in step l′);
n) immersing the freeze-dried product from step m) in a CaCl 2 solution at a concentration between 0.5 and 1.5 M for a period between 15 and 45 minutes, followed by washing with immersion in distilled water; and
o) again subjecting to freeze-drying treatment the material of the CaCl 2 -treated product from step n).

5. The process according to claim 4 , wherein sodium alginate is used as hydrophilic polymer.

6. The process according to claim 4 , wherein the weight ratio between the paramagnetic core and the surrounding polymeric material is between 40:60 and 80:20.

7. The process according to claim 1 , wherein, at the end of the process, between 3 and 5 mm of the upper face and of the lower face of the obtained product are mechanically removed.

8. The process according to claim 4 , wherein the water soluble compound of phosphorus employed in step h) is phosphoric acid.

Assignees

• Consiglio Nazionale Ricerche

Inventors

• Sandri Monica
• Tampieri Anna
• Sprio Simone

Classifications

• C08K5/06

  Ethers; Acetals; Ketals; Ortho-esters · CPC title

• C08J3/075 Primary

  Macromolecular gels · CPC title

• A61M16/1045

  Devices for humidifying or heating the inspired gas by using recovered moisture or heat from the expired gas · CPC title

• C08L89/06

  derived from leather or skin {, e.g. gelatin} · CPC title

• C08K5/1545

  Six-membered rings · CPC title