Hollow fiber membrane having improved diffusion properties

Patent metadata

Field	Value
Publication number	US-11628407-B2
Application number	US-201816493311-A
Country	US
Kind code	B2
Filing date	Mar 16, 2018
Priority date	Mar 17, 2017
Publication date	Apr 18, 2023
Grant date	Apr 18, 2023

Abstract

The invention relates to an undulated thermostable hollow fiber membrane of reduced wall thickness, wherein the wall thickness amounts to 20 μm or greater and 30 μm or less and the waveform of the hollow fiber membrane exhibits a wavelength in the range of from more than 1 mm and less than 5 mm. In particular, the invention relates to a method for producing an undulated thermostable hollow fiber membrane of lower wall thickness.

First claim

The invention claimed is:

1. An undulated hollow fiber membrane, comprising at least one first hydrophobic polymer and at least one second hydrophilic polymer, having a wall thickness of 20 μm or greater and 30 μm or less, wherein the at least one first hydrophobic polymer is a polyarylether, polyamide, polyester, polycarbonate, polyacrylate and methacrylate, polymethacrylimide, polyvinylidenfluoride, polyimide, polyacrylnitrile group, or any copolymer thereof, and the at least one second hydrophilic polymer is a polyvinylpyrrolidone or polyethylene glycol group, and a waveform of the hollow fiber membrane exhibits a wavelength in a range of from greater than 1 mm and less than 4 mm and wherein a porosity of the hollow fiber membrane is 65% to less than 78%, and a drop in sodium clearance of the hollow fiber membrane is less than 13 ml/min after a heat sterilization process of above 100° C.

2. The hollow fiber membrane according to claim 1 , wherein the waveform has an amplitude in a range of from 0.005 to 0.15 mm.

3. The hollow fiber membrane according to claim 1 , wherein the hollow fiber membrane has a luminal diameter of from 160 to 230 μm.

4. The hollow fiber membrane according to claim 1 , wherein the waveform is substantially sinusoidal.

5. The hollow fiber membrane according to claim 2 , wherein the amplitude is from 0.01 to 0.12 mm.

6. A method for producing an undulated hollow fiber membrane containing at least one first hydrophobic polymer, comprising the steps:
producing a hollow fiber membrane having a wall thickness of 20 μm or greater and 30 μm or less and having a porosity of 65% to less than 78% from a spinning material in a spinning and phase inversion process;
producing a waveform of predetermined wavelength and amplitude with at least one undulating tool; and
processing the hollow fiber membrane with the at least one undulating tool so as to yield an undulation wavelength of more than 1 mm and less than 4 mm, wherein a drop in sodium clearance of the hollow fiber membrane is less than 13 ml/min after a heat sterilization process of above 100° C.

7. The method for producing a hollow fiber membrane according to claim 6 , wherein the at least one undulating tool comprises two intermeshing gears between which the hollow fiber membrane is passed.

8. The method for producing a hollow fiber membrane according to claim 6 , wherein an engagement depth of teeth of the at least one undulating tool amounts to 0.1 to 0.5 mm.

9. The method for producing a hollow fiber membrane according to claim 6 , wherein the spinning material contains at least one first hydrophobic polymer that is a polyarylether, polyamide, polyester, polycarbonate, polyacrylate and methacrylate, polymethacrylimide, polyvinylidenfluoride, polyimide or polyacrylnitrile group or any copolymer thereof, and the spinning material contains at least one second hydrophilic polymer that is a polyvinylpyrrolidone or polyethylene glycol group, and at least one solvent.

10. The method for producing a hollow fiber membrane according to claim 9 , wherein said at least one solvent is methylpyrrolidone, N,N-dimethyl acetamide, N,N-Diemthylformamide or dimethyl sulfoxide.

11. A hollow fiber membrane dialyzer comprising a plurality of the hollow fiber membrane in accordance with claim 1 .

12. A method for producing a hollow fiber membrane dialyzer comprising the steps:
providing a hollow fiber membrane bundle comprising a plurality of the hollow fiber membrane in accordance with claim 1 ;
providing a filter housing;
introducing the hollow fiber membrane bundle into the filter housing and potting ends of the hollow fiber membranes in the filter housing with a potting compound to form a potted membrane;
reopening the ends of the potted membrane so as to enable a flow through a lumen of most of the hollow fiber membranes, and final assembly of the hollow fiber membrane dialyzer; and
sterilizing the hollow fiber membrane dialyzer in the heat sterilization process.

13. The method for producing a hollow fiber membrane dialyzer according to claim 12 , wherein the heat sterilization process comprises a step in which the hollow fiber membrane dialyzer is flushed with water or water vapor heated to 100 to 150° C.

14. The method for producing a hollow fiber membrane dialyzer according to claim 13 , wherein the water or water vapor is conducted into an interior of the hollow fiber membranes and permeates through a membrane wall to an exterior of the hollow fiber membranes under application of pressure.

15. The method for producing a hollow fiber membrane dialyzer according to claim 12 , wherein the hollow fiber membranes are dried at a temperature of from 100° C. to 150° C.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Keller Torsten
• Sander Roland
• Raiko Igor
• Finkler Christian

Classifications

• A61L2103/15

  Laboratory, medical or dentistry appliances, e.g. catheters or sharps · CPC title

• B01D61/243 Primary

  Dialysis · CPC title

• B01D69/0871

  Fibre guidance after spinning through the manufacturing apparatus · CPC title

• A61M2207/00

  Methods of manufacture, assembly or production · CPC title

• B01D69/084 Primary

  Undulated fibres · CPC title