Multiple dosage injector with rack and pinion dosage system

Patent metadata

Field	Value
Publication number	US-11628260-B2
Application number	US-202016797447-A
Country	US
Kind code	B2
Filing date	Feb 21, 2020
Priority date	Mar 11, 2013
Publication date	Apr 18, 2023
Grant date	Apr 18, 2023

Abstract

A dispensing mechanism for delivering a dosage of medicament including a housing, a push button, a crank arm that is slideably engageable with the push button, a ram, and a ratchet gear releasably engageable with the crank arm and ram, translation of the push button along an axis causing the crank arm to engage and rotate the ratchet gear which causes the ram to distally advance relative to the housing.

First claim

The invention claimed is:

1. A dispensing mechanism, comprising:
a housing having a proximal-distal axis;
a ram within the housing, movable in a distal direction relative to the housing;
a push button moveable along the proximal-distal axis relative to the housing, the push button including a push button slot at a distal portion of the push button;
a crank arm having a pawl tooth, a pivot point, and a crank arm engagement member slideably engageable with the push button slot such that movement of the push button causes the crank arm engagement member to move along the push button slot, causing rotation of the crank arm about the pivot point; and
a ratchet gear having a first set of teeth releasably engageable with the pawl tooth and a second set of teeth releasably engageable with the ram,
wherein engagement of the pawl tooth with the first set of teeth of the ratchet gear causes the ratchet gear to rotate, causing the ram to distally advance relative to the housing, and
wherein the ram includes a lockout protrusion and the push button includes a lockout aperture, the lockout aperture engaging with the lockout protrusion in a locked position.

2. The dispensing mechanism of claim 1 , further comprising an anti-reverse mechanism including:
at least one housing ratchet integrally formed on an internal surface of the housing; and
a flexible column integrally formed extending from a distal portion of the push button, the flexible column having a flexible column protrusion at a proximal end thereof,
wherein as the push button moves along the proximal-distal axis, the flexible column protrusion engages the housing ratchet and restricts movement of the push button to one direction during a resetting motion.

3. The dispensing mechanism of claim 2 , wherein the flexible column protrusion is almond shaped.

4. The dispensing mechanism of claim 1 , wherein the ram includes at least two sets of teeth.

5. The dispensing mechanism of claim 4 , wherein at least one set of teeth has involute spur rack geometry.

6. The dispensing mechanism of claim 4 , wherein a first set of ram teeth are configured to engage the second set of teeth of the ratchet gear, and a second set of ram teeth are configured to engage a housing protrusion, the housing protrusion being integrally formed within the housing and configured to facilitate movement of the ram in one direction.

7. The dispensing mechanism of claim 6 , wherein the first set of ram teeth and the second set of teeth of the ratchet gear have similar corresponding involute gear teeth geometry.

8. The dispensing mechanism of claim 1 , wherein the push button slot is oriented at an oblique angle with respect to the proximal-distal axis.

9. The dispensing mechanism of claim 1 , wherein the push button slot has a portion that is oriented at an oblique angle with respect to the proximal-distal axis and a portion that is oriented parallel to the proximal-distal axis.

10. The dispensing mechanism of claim 1 , wherein the first set of teeth of the ratchet gear control a dose amount of an injector.

11. An injector comprising:
the dispensing mechanism of claim 1 ;
a cartridge disposed within the housing;
a medicament contained within the cartridge;
a plunger disposed in the cartridge to seal the medicament therein, wherein the ram is associated with the plunger for forcing the plunger in a distal direction relative to the housing for ejecting a dose of the medicament; and
a needle in fluid communication with the cartridge for injecting doses of the medicament into a patient.

12. The injector of claim 11 , wherein the medicament includes a parathyroid hormone.

13. The injector of claim 12 , wherein the parathyroid hormone is teriparatide.

14. The injector of claim 11 , wherein the medicament includes glucagon-like peptide receptor agonists.

15. The injector of claim 14 , wherein the glucagon-like peptide receptor agonists are exenatide.

16. The injector of claim 14 , wherein the glucagon-like peptide receptor agonists are liraglutide.

17. The dispensing mechanism of claim 1 , wherein the lockout protrusion engages with the lockout aperture in the locked position after a dose of a medicament is ejected.

18. The dispensing mechanism of claim 1 , wherein the lockout protrusion engages a sidewall of the lockout aperture to restrict movement of the push button when the lockout protrusion is in the locked position.

19. The dispensing mechanism of claim 18 , wherein the lockout protrusion prevents proximal movement of the push button relative to the housing when the lockout protrusion is in the locked position.

20. The dispensing mechanism of claim 1 , wherein the dispensing mechanism is configured to eject a plurality of doses of a medicament including a final dose of the medicament and the lockout protrusion engages the lockout aperture in the locked position after the final dose of the medicament is ejected.

21. The dispensing mechanism of claim 1 , wherein the ram is prevented from moving proximally relative to the housing in the locked position.

Assignees

• Antares Pharma Inc

Inventors

• Madsen Patrick
• Pflaumer Hans
• Swanson Kevin

Classifications

• A61M5/31586

  performed by rotationally moving or pivoted actuator, e.g. an injection lever or handle · CPC title

• A61M5/31595

  Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking · CPC title

• A61M5/31585 Primary

  performed by axially moving actuator, e.g. an injection button · CPC title

• A61M5/31575

  using scaling up or down transmissions, e.g. gearbox · CPC title