Immunostimulating compositions and uses therefore

Patent metadata

Field	Value
Publication number	US-11623945-B2
Application number	US-201816483806-A
Country	US
Kind code	B2
Filing date	Feb 6, 2018
Priority date	Feb 6, 2017
Publication date	Apr 11, 2023
Grant date	Apr 11, 2023

Abstract

The present invention relates to immunogenic polypeptides, immunogenic fragments thereof and compositions comprising same, for use in eliciting an immune response in a subject to a tick. The invention also provides for methods of using said compositions and polypeptides.

First claim

The invention claimed is:

1. A composition comprising:
a recombinant or synthetic polypeptide comprising or consisting of the amino acid sequence set forth in residues 140-154 of SEQ ID NO: 7 (SEQ ID NO: 52) and/or residues 159-179 of SEQ ID NO: 7 (SEQ ID NO: 51);
an adjuvant for potentiating an immune response to the polypeptide.

2. The composition according to claim 1 , wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in:
residues 20-37 of SEQ ID NO: 10 (SEQ ID NO: 58);
residues 96-106 of SEQ ID NO: 10 (SEQ ID NO: 59);
residues 164-173 of SEQ ID NO: 10 (SEQ ID NO: 60); and
residues 185-200 of SEQ ID NO: 10 (SEQ ID NO: 61).

3. The composition according to claim 1 , wherein the composition further comprises a polypeptide comprising or consisting of the amino acid sequence residues 198-209 of SEQ ID NO: 14, (SEQ ID NO: 70).

4. The composition according to claim 1 , wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in:
residues 91-132 of SEQ ID NO: 16 (SEQ ID NO: 72);
residues 104-204 of SEQ ID NO: 16 (SEQ ID NO: 73); and
residues 117-132 of SEQ ID NO: 16 (SEQ ID NO: 74).

5. The composition according to claim 1 , wherein the composition further comprises:
a carrier protein, conjugated to the recombinant or synthetic polypeptide; and/or
a pharmaceutically acceptable carrier, excipient, or diluent.

6. The composition according to claim 1 , wherein the recombinant or synthetic polypeptide comprises or consists of the amino acid sequence set forth in SEQ ID NO: 7.

7. The composition according to claim 1 , wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in SEQ ID NO: 10.

8. The composition according to claim 1 , wherein the recombinant or synthetic polypeptide comprises or consists of the amino acid sequence set forth in SEQ ID NO: 7 and wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in SEQ ID NO: 10.

9. The composition according to claim 1 , wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in SEQ ID NO: 14.

10. The composition according to claim 1 , wherein the recombinant or synthetic polypeptide comprises or consists of the amino acid sequence set forth in SEQ ID NO: 7 and wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in SEQ ID NO: 14.

11. The composition according to claim 1 , wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in SEQ ID NO: 16.

12. The composition according to claim 1 , wherein the recombinant or synthetic polypeptide comprises or consists of the amino acid sequence set forth in SEQ ID NO: 7 and wherein the composition further comprises a polypeptide that comprises or consists of the amino acid sequence set forth in SEQ ID NO: 16.

13. The composition according to claim 1 , wherein the recombinant or synthetic polypeptide comprises or consists of the amino acid sequence set forth in SEQ ID NO: 7 and wherein composition further comprises a carrier protein, conjugated to the recombinant or synthetic polypeptide; and/or a pharmaceutically acceptable carrier, excipient, or diluent.

Assignees

• Australian Meat & Live Stock
• The State Of Queensland
• Us Secretary Of Agriculture
• Us Agriculture

Inventors

• Tabor Alicja
• Bellgard Matthew
• Rodriguez Valle Manuel
• Guerrero Felicito

Classifications

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61K2039/53

  DNA (RNA) vaccination · CPC title

• A61K39/0003

  Invertebrate antigens · CPC title

• C07K14/43527 Primary

  from ticks · CPC title

• A61K2039/552

  Veterinary vaccine · CPC title