Devices and methods for treatment of tumors using electromagnetic signal

Patent metadata

Field	Value
Publication number	US-11623085-B2
Application number	US-201917250735-A
Country	US
Kind code	B2
Filing date	Aug 29, 2019
Priority date	Aug 29, 2018
Publication date	Apr 11, 2023
Grant date	Apr 11, 2023

Abstract

Systems and methods for treating cancerous tumors (including glioblastoma multiforme (GBM)) with electrotherapy, such as deep brain stimulation (DBS) technology, as disclosed herein. One or more configurations can be generated based on a patients tumor characteristics. The selected configurations can be electrode configurations or settings for an electrical source coupled to the electrodes. The one or more configurations can be targeted for inhibiting cell growth process, such as to inhibit mitosis, immune suppression, or to inhibit DNA replication. Inhibition of cell growth processes can initiate death of the cancerous cells.

First claim

What is claimed is:

1. A signal generator electronically coupled to a plurality of electrodes, the signal generator comprising:
a processor configured to:
receive a first set of tumor-specific electromagnetic field data and generate a first corresponding set of stimulation settings, and
receive a second set of tumor-specific electromagnetic field data and generate a second corresponding set of stimulation settings based on a first tumor profile, a second tumor profile, and a size or a rate of change of the tumor profile and based on the first tumor profile and the second tumor profile,
wherein the first and second sets of stimulation settings each comprise a specific output setting for each of the plurality of electrodes;

a memory configured to receive and store the set of stimulation settings from the processor; and
a communication engine configured to deliver the specific output settings to each corresponding one of the plurality of electrodes to generate a tumor-specific electromagnetic field based upon to the tumor-specific electromagnetic field data,
wherein the specific output settings include a set of electrical parameters based upon the tumor-specific electromagnetic field data.

2. The signal generator of claim 1 , wherein the processor is configured to receive the first tumor-specific electromagnetic field data from a programmer module and generate the first set of stimulation settings based on the first tumor profile and a desired effect on the tumor.

3. The signal generator of claim 2 , wherein the first tumor profile is produced based on a tumor type and a three-dimensional model of the tumor.

4. The signal generator of claim 2 , further comprising the programmer module.

5. The signal generator of claim 1 , wherein the one or more sets of stimulation settings are:
obtained using a computer-implemented algorithm,
delivered simultaneously,
delivered cyclically or randomly, or
delivered by alternating among the one or more sets of stimulation settings.

6. The signal generator of claim 1 , wherein a first set of the one or more sets of stimulation settings targets mitosis inhibition, wherein one of the stimulation parameters included in the first set is frequency, and wherein the frequency is in a range of 61 Hz to 200 Hz.

7. The signal generator of claim 1 , wherein a second set of the one or more sets of stimulation settings targets immune suppression, wherein one of the stimulation parameters included in the second set is frequency, and wherein the frequency is in a range of 300 Hz to 700 Hz.

8. The signal generator of claim 1 , wherein a third set of the one or more sets of stimulation settings targets inhibition of DNA replication, wherein one of the stimulation parameters included in the third set is frequency, and wherein the frequency is equal to or greater than 1,000 Hz.

9. The signal generator of claim 1 , the processor further configured to receive a second set of tumor-specific electromagnetic field data and generate a second corresponding set of stimulation settings.

10. The signal generator of claim 9 , the second set of tumor-specific electromagnetic field data based on a first tumor profile, a second tumor profile, and a rate of change of the of the tumor profile based on the first tumor profile and the second tumor profile.

11. A signal generator electronically coupled to a plurality of electrodes arranged on an implantation lead, the signal generator comprising:
a processor configured to receive a set of tumor-specific electromagnetic field data and generate a corresponding set of stimulation settings, wherein the set of stimulation settings each comprise a specific output setting for each of the plurality of electrodes in an electrode configuration;
a memory configured to receive and store the set of stimulation settings from the processor; and
a communication engine configured to deliver the specific output settings to each corresponding one of the plurality of electrodes to generate a tumor-specific electromagnetic field based upon to the tumor-specific electromagnetic field data,
wherein the electrode configurations are received by the processor from a programmer module and based on a tumor profile and a desired effect on the tumor or obtained using a computer-implemented algorithm and are customized based on the profile and a desired effect on the tumor;
wherein the specific output settings include a set of electrical parameters based upon the tumor-specific electromagnetic field data; and
wherein the implantation lead includes one of the one or more electrode configurations and is generated through 3D printing.

12. The signal generator of claim 11 , wherein the processor is further configured to receive one or more electrode configurations.

13. The signal generator of claim 12 , wherein the one or more electrode configurations are:
received from a programmer module and based on the first tumor profile and a desired effect on the tumor, or
obtained using a computer-implemented algorithm.

14. The signal generator of claim 13 , wherein the one or more electrode configurations comprise an array of the plurality of electrodes on an implantation lead.

15. The signal generator of claim 14 , wherein the one or more electrode configurations are selected from readily available implantation leads based on the profile and a desired effect on the tumor.

16. The signal generator of claim 14 , wherein the implantation lead is configured for:
implantation in a brain of a patient, or
epidural implantation.

17. The signal generator of claim 13 , wherein the one or more electrode configurations are customized based on the profile and a desired effect on the tumor.

18. The signal generator of claim 12 , wherein an electrode configuration includes two or more electrodes and each of the two or more electrodes is stimulated with a different one or more of the one or more stimulation settings.

19. A signal generator coupled to a plurality of electrodes, the signal generator comprising:
a processor configured to receive:
a set of tumor-specific electromagnetic field data and generate a corresponding set of stimulation settings, wherein the set of stimulation settings comprise a specific output setting for each of the plurality of electrodes; and
one or more electrode configurations comprising a configuration of the plurality of electrodes on an implantation lead,
wherein the implantation lead is integrated with a venous filter, and
wherein the configuration is based on a tumor profile or a computer-implemented algorithm and selected based on the profile and a desired effect on the tumor;

a memory configured to receive and store the set of stimulation settings from the processor; and
a communication engine configured to deliver the specific output settings to each corresponding one of the plurality of electrodes to generate a tumor-specific electromagnetic field based upon to the tumor-specific electromagnetic field data,
wherein the specific output settings include a set of electrical parameters based upon the tumor-specific electromagnetic field data.

Assignees

• Univ Minnesota

Inventors

• Chen Clark C
• Molnar Gregory Frederick

Classifications

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• A61N1/0534

  Electrodes for deep brain stimulation · CPC title

• A61N1/37211

  Means for communicating with stimulators · CPC title

• A61B18/14

  Probes or electrodes therefor · CPC title

• G16H30/40

  for processing medical images, e.g. editing · CPC title