Pulse wave velocity, arterial compliance, and blood pressure

Patent metadata

Field	Value
Publication number	US-11622730-B2
Application number	US-201515527412-A
Country	US
Kind code	B2
Filing date	Nov 17, 2015
Priority date	Nov 17, 2014
Publication date	Apr 11, 2023
Grant date	Apr 11, 2023

Abstract

Disclosed are methods for determining physiological parameters of an individual including blood pressure, arterial compliance, flow velocity, and pressure wave velocity. A noninvasive method for determining the blood pressure of a patient is based on measurements of flow velocity, pulse wave velocity and arterial compliance. A noninvasive method for determining the arterial compliance of a patient is based on measurements of blood pressure, flow velocity, and pulse wave velocity.

First claim

What is claimed:

1. A method for determining a blood pressure of a subject, the method comprising:
measuring a transit time of a pulse wave between two points of an arterial segment or segments of the subject by capturing one or more waveforms or images using one or more sensors or imaging;
determining a value for pulse wave velocity within the arterial segment or segments of the subject based on the transit time and an arterial distance between the two points;
determining a value for flow velocity within the arterial segment or segments of the subject;
determining a value for an arterial compliance parameter of the subject; and
generating a value for the blood pressure p of the subject by applying a model of fluid-structure interaction incorporating conservation of mass and momentum for a fluid, and linear elasticity of a structure, the model of fluid-structure interaction comprising the equation

p
=

2
⁢

(

ρ
⁢

D
⁡
(

PWV
-
u

)

2

-
1

)

D

,

 where PWV is the pulse wave velocity, u is the flow velocity, ρ is the density of the fluid, and D is the arterial compliance parameter.

2. The method of claim 1 , wherein the arterial compliance parameter comprises distensibility.

3. The method of claim 1 , wherein the blood pressure is a systolic pressure and the pulse wave velocity is a peak pulse wave velocity.

4. The method of claim 1 , wherein the blood pressure is a diastolic pressure and the pulse wave velocity is a minimum pulse wave velocity.

5. The method of claim 1 , wherein the blood pressure is a systolic blood pressure and the flow velocity is a peak flow velocity.

6. The method of claim 1 , wherein the blood pressure is a diastolic blood pressure and the flow velocity is a minimum flow velocity.

7. The method of claim 1 , wherein determining the value for flow velocity includes at least one of: measuring the flow velocity using a sensor, or estimating the flow velocity based on scaling a physiological parameter associated with the flow velocity.

8. The method of claim 1 , wherein determining the value for the arterial compliance parameter includes at least one of: measuring the arterial compliance parameter using at least one of a sensor or imaging, or estimating the arterial compliance parameter based on a calculation or a population based estimate.

9. A method for determining an arterial compliance parameter of a subject, the method comprising:
measuring a transit time of a pulse wave between two points of an arterial segment or segments of the subject by capturing one or more waveforms or images using one or more sensors or imaging;
determining a value for pulse wave velocity within the arterial segment or segments of the subject based on the transit time and an arterial distance between the two points;
measuring a value for flow velocity within the arterial segment or segments of the subject;
determining a flow corrected value for the pulse wave velocity based on the value for the flow velocity;
measuring a value for blood pressure of the subject;
receiving a value for blood density of the subject; and
determining the arterial compliance parameter of the subject by applying a model of fluid-structure interaction incorporating conservation of mass and momentum for a fluid, and linear elasticity of a structure, the model of fluid-structure interaction comprising:
populating any one of equations

D
=

[

ρ
*

PWV
f
2

-

p
2

]

-
1

⁢

or
⁢

D

=

[

∑

i
=
1

N

(

ρ
*

PWV
f
2

-

p
2

)

i

N

]

-
1

,

where PWV f is the flow corrected value for the pulse wave velocity, ρ is the density of the fluid, p is the blood pressure, and N is the number of vessels within the arterial segment or segments.

10. The method of claim 9 , wherein the arterial compliance parameter comprises distensibility.

11. The method of claim 9 , wherein the blood pressure is a systolic pressure and the pulse wave velocity is a peak pulse wave velocity.

12. The method of claim 9 , wherein the blood pressure is a diastolic pressure and the pulse wave velocity is a minimum pulse wave velocity.

13. The method of claim 9 , wherein the blood pressure is a systolic blood pre

Assignees

• Borkholder David A
• Liberson Alexander S
• Lillie Jeffrey S
• Day Steven W
• Rochester Institute Tech

Inventors

• Borkholder David A
• Liberson Alexander S
• Lillie Jeffrey S
• Day Steven W

Classifications

• A61B5/02007

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• A61B5/352

  Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval · CPC title

• A61B5/7278 Primary

  Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals · CPC title

• A61B5/02125

  of pulse wave propagation time · CPC title

• G09B23/30

  Anatomical models {(G09B23/281 - G09B23/288 take precedence)} · CPC title