Device, method, and program for visualizing network of blood vessels of skin

Patent metadata

Field	Value
Publication number	US-11622688-B2
Application number	US-202016830807-A
Country	US
Kind code	B2
Filing date	Mar 26, 2020
Priority date	Sep 29, 2017
Publication date	Apr 11, 2023
Grant date	Apr 11, 2023

Abstract

A device of an embodiment includes: an optical mechanism; a control computation unit that controls driving of the optical mechanism, acquires a tomographic image of skin by processing an optical interference signal from an optical system, and calculates a network of blood vessels on the basis of the tomographic image; and a display device that displays an image of the network of blood vessels. The control computation unit sets a reference profile obtained by function approximation of an intensity profile in a depth direction of the acquired tomographic image, calculates a difference between an intensity value on the reference profile and an actual intensity value as an outlier V, the intensity values being those in the depth direction in the tomographic image, determines, as blood vessels or blood vessel candidates, coordinates with the outliers V within a predetermined blood vessel determination range, and calculates the network of blood vessels.

First claim

What is claimed is:

1. A blood vessel visualizing device that includes an optical system using optical coherence tomography, and visualizes a network of blood vessels of skin, the blood vessel visualizing device comprising:
an optical mechanism that guides light from a light source to tissue of the skin to scan the skin tissue;
a control computation unit that controls driving of the optical mechanism, acquires a tomographic image of the skin by processing an optical interference signal from the optical system, and calculates a network of blood vessels on the basis of the tomographic image; and
a display unit that displays an image of the network of blood vessels, wherein
the control computation unit sets a reference intensity profile obtained by function approximation of an intensity profile in a depth direction of the acquired tomographic image,
the control computation unit calculates a difference between an intensity value on the reference intensity profile and an actual intensity value as an outlier, according to the intensity value on the reference intensity profile in the depth direction in the tomographic image, and
the control computation unit determines, as blood vessels or blood vessel candidates, coordinates with the outliers of the intensity value within a predetermined blood vessel determination range, and calculates the network of blood vessels.

2. The blood vessel visualizing device according to claim 1 , wherein the control computation unit determines, as lymphatic vessels or lymphatic vessel candidates, coordinates with the outliers within a predetermined lymphatic vessel determination range, the lymphatic vessel determination range being set to a lower intensity range than the blood vessel determination range.

3. A blood vessel visualizing method for visualizing a network of blood vessels of skin, the method comprising:
a tomographic image acquiring step of acquiring a tomographic image of the skin by using optical coherence tomography;
a reference value setting step of setting a reference intensity profile obtained by function approximation of an intensity profile in a depth direction of an acquired tomographic image;
a computing step of calculating a difference between an intensity value on the reference intensity profile and an actual intensity value as an outlier, according to the intensity value on the reference intensity profile in the depth direction in the tomographic image, determining, as blood vessels or blood vessel candidates, coordinates with the outliers of the intensity value within a predetermined blood vessel determination range, and calculating the network of blood vessels; and
a displaying step of displaying the calculated network of blood vessels.

4. A non-transitory computer readable medium comprising a program for causing a computer to implement:
a function of setting a reference intensity profile obtained by function approximation of an intensity profile in a depth direction of a tomographic image acquired by using optical coherence tomography;
a function of calculating a difference between an intensity value on the reference intensity profile and an actual intensity value as an outlier, according to the intensity value on the reference intensity profile in the depth direction in the tomographic image, determining, as blood vessels or blood vessel candidates, coordinates with the outliers of the intensity value within a predetermined blood vessel determination range, and calculating a network of blood vessels; and
a function of outputting signals to display the calculated network of blood vessels.

Assignees

• Shiseido Co Ltd
• Univ Meijo

Inventors

• Hara Yusuke
• Yamashita Toyonobu
• Ninomiya Masato
• SAEKI Souichi

Classifications

• G01B9/02091

  Tomographic interferometers, e.g. based on optical coherence · CPC title

• A61B5/489

  Blood vessels · CPC title

• A61B5/0066 Primary

  Optical coherence imaging · CPC title

• A61B5/0082 Primary

  adapted for particular medical purposes · CPC title

• A61B5/418

  lymph vessels, ducts or nodes · CPC title