Attenuation estimation using ultrasound

Patent metadata

Field	Value
Publication number	US-11619728-B2
Application number	US-202217571859-A
Country	US
Kind code	B2
Filing date	Jan 10, 2022
Priority date	Jan 8, 2019
Publication date	Apr 4, 2023
Grant date	Apr 4, 2023

Abstract

Systems and methods for attenuation measuring using ultrasound. In various embodiments, echo data corresponding to a detection of echoes of one or more ultrasound signals transmitted into tissue are received. The echoes can be received from a range of depths of the tissue. Spectral measurements across the range of depths of the tissue are obtained using the echo data. Attenuation characteristics of the tissue across the range of depths of the tissue can be estimated using the spectral measurements across the range of depths of the tissue. Specifically, the attenuation characteristics of the tissue can be estimated using the spectral measurements and known spectral characteristics of the one or more ultrasound signals transmitted into the tissue.

First claim

What is claimed is:

1. A method for estimating attenuation characteristics of a tissue using ultrasound comprising:
receiving echo data corresponding to a detection of echoes of one or more ultrasound signals transmitted into the tissue, wherein the echoes are received from a range of depths of the tissue;
obtaining spectral measurements across the range of depths of the tissue using the echo data;
estimating attenuation characteristics of the tissue across the range of depths of the tissue using the spectral measurements across the range of depths of the tissue and known spectral characteristics of the one or more ultrasound signals transmitted into the tissue;
filtering the echo data generated by the one or more ultrasound signals based on a depth of the one or more ultrasound signals in the tissue where the corresponding echo data is created; and
obtaining the spectral measurements across, at least part of, the range of depths of the tissue using the filtered echo data.

2. The method of claim 1 , wherein the spectral measurements correspond to overlapping depth levels across the range of depths of the tissue, the method further comprising averaging the spectral measurements at the overlapping depth levels.

3. The method of claim 1 , wherein the echo data is filtered to decrease a central frequency of the echo data as the one or more ultrasound signals used to generate the echo data pass further into the tissue along the range of depths of the tissue.

4. The method of claim 1 , further comprising averaging the spectral measurements across at least a portion of the range of depths of the tissue to improve an overall signal to noise ratio across the range of depths of the tissue.

5. The method of claim 1 , wherein the one or more ultrasound signals transmitted into the tissue are formed by one or more broadband pulses.

6. The method of claim 1 , further comprising:
generating a set of fast Fourier transforms based on the echo data, wherein each fast Fourier transform in the set of fast Fourier transforms is associated with a depth value;
generating a set of point estimates for a frequency dependent filtering coefficient included as part of the spectral measurements across the range of depths of the tissue, where each point estimate in the set of point estimates corresponds to a fast Fourier transform in the set of fast Fourier transforms; and
extracting a set of attenuation coefficients based on the set of point estimates for the frequency dependent filtering coefficient, the attenuation coefficients representing one or more attenuation levels of the tissue across the range of depths of the tissue.

7. The method of claim 6 , wherein the set of attenuation coefficients is extracted based on a slope of at least one line formed from the set of point estimates.

8. The method of claim 6 , further comprising applying a least means square fit on the set of attenuation coefficients to generate a varying estimate of attenuation levels across the range of depths of the tissue.

9. The method of claim 6 , further comprising:
generating one or more ultrasound images using the echo data; and
applying a moving block fast Fourier transform to the one or more ultrasound images to generate the set of fast Fourier transforms.

10. The method of claim 9 , wherein the moving block fast Fourier transform is applied to the one or more ultrasound images is applied in a direction along the range of depths of the tissue.

11. The method of claim 9 , wherein one or more fast Fourier transforms in the set of fast Fourier transforms are generated to have overlap with one or more previous fast Fourier transforms created by applying the moving block fast Fourier transform.

12. The method of claim 9 , further comprising applying a plurality of moving block fast Fourier transforms to the one or more ultrasound images to generate the set of fast Fourier transforms, wherein the set of fast Fourier transforms includes a plurality of subsets of fast Fourier transforms and each subset of fast Fourier transforms corresponding to one of the plurality of moving block fast Fourier transforms used to create each subset of fast Fourier transforms.

13. The method of claim 12 , further comprising averaging the set of attenuation coefficients based on the plurality of subsets of fast Fourier transforms to estimate the one or more attenuation levels of the tissue across the range of depths of the tissue.

14. The method of claim 6 , wherein the set of attenuation coefficients is extracted based on the set of point estimates for the frequency dependent filtering coefficient included as part of the spectral measurements across the range of depths of the tissue and the known spectral characteristics of the one or more ultrasound signals transmitted into the tissue.

15. The method of claim 1 , further comprising:
averaging the echo data generated by the one or more ultrasound signals based on a depth of the one or more ultrasound signals in the tissue where the corresponding echo data is created; and
obtaining the spectral measurements across, at least part of, the range of depths of tissue using the averaged echo data.

16. A system for estimating attenuation characteristics of a tissue using ultrasound comprising:
one or more processors; and
a computer-readable medium providing instructions accessible to the one or more processors to cause the one or more processors to perform operations comprising:
receiving echo data corresponding to a detection of echoes of one or more ultrasound signals transmitted into the tissue, wherein the echoes are received from a range of depths of the tissue;
obtaining spectral measurements across the range of depths of the tissue using the echo data;
estimating attenuation characteristics of the tissue across the range of depths of the tissue using the spectral measurements across the range of depths of the tissue and known spectral characteristics of the one or more ultrasound signals transmitted into the tissue;
filtering the echo data generated by the one or more ultrasound signals based on a depth of the one or more ultrasound signals in the tissue where the corresponding echo data is created; and
obtaining the spectral measurements across, at least part of, the range of depths of the tissue using the filtered echo data.

17. The system of claim 16 , wherein the operations further comprise:
identifying areas in the range of depths of the tissue represented by speckle in the spectral measurements; and
continuing to obtain additional spectral measurements for the areas.

18. The system of claim 16 , wherein the operations further comprise averaging the spectral measurements across at least a portion of the range of depths of the tissue to improve an overall signal to noise ratio across the range of depths of the tissue.

19. The system of claim 16 , wherein the spectral measurements correspond to overlapping depth levels across the range of depths of the tissue, the operations further comprising averaging the spectral measurements at the overlapping depth levels.

Assignees

• Shenzhen Mindray Biomedical Electronics Co Ltd

Inventors

• Mclaughlin Glen W
• Gee Albert

Classifications

• A61B8/5269 Primary

  involving detection or reduction of artifacts · CPC title

• G06T2207/20056

  Discrete and fast Fourier transform, [DFT, FFT] · CPC title

• G01S7/52036 Primary

  using analysis of echo signal for target characterisation · CPC title

• G06T2207/10132

  Ultrasound image · CPC title

• A61B8/14

  Echo-tomography · CPC title