Autonomous inorganic material synthesis machine

Patent metadata

Field	Value
Publication number	US-11610652-B2
Application number	US-202016868037-A
Country	US
Kind code	B2
Filing date	May 6, 2020
Priority date	May 6, 2020
Publication date	Mar 21, 2023
Grant date	Mar 21, 2023

Abstract

A synthesis machine for preparation of a targeted inorganic material for recommended synthesis by a computer program that determines optimal solid-state methods for synthesis of an inorganic material. The computational method involves inputting a target inorganic material, querying structural data and thermodynamic data for the target inorganic material, enumerating possible synthetic reactions to construct a synthetic reaction database with a viable subset of the possible synthetic methods. The routine generates a nucleation metric and competition metric that are combined to provide recommended synthetic methods. The output for each of the recommended syntheses are input into a robotic synthesis machine where the delivery of reactants, reaction conditions, and analysis of extent of reaction, and product quality is controlled by a processor.

First claim

What is claimed is:

1. A synthesis machine for preparation of a target inorganic material, comprising:
a synthesis planner module coupled with a processor that outputs from a synthesis route recommendation computer program at least one solid-state synthetic method for the preparation of the target inorganic material, where the at least one solid-state synthetic method comprises a viable subset of a multiplicity of possible synthetic reactions;
at least one reaction vessel for containment of at least one reactant for formation of the target inorganic material, wherein each reaction vessel is for the performance of a single solid-state synthetic method under a first stoichiometry and a first set of conditions contained in the output of the computer program, or as an enumerated stoichiometry and enumerated set of conditions modified according to a result of a previous preparation of the target inorganic material by the synthesis machine, ultimately resulting from the first stoichiometry and the first set of conditions;
at least one delivery mechanism to provide a plurality of reactants to the at least one reaction vessel, wherein a quantity of each of the plurality of reactants is provided at the first stoichiometry or in the enumerated stoichiometry;
at least one controller configured for:
controlling the first set of conditions or the enumerated set of conditions required for the at least one solid-state synthetic method;
monitoring the first set of conditions or the enumerated set of conditions during the at least one solid-state synthetic method; and
evaluating a progress of a reaction of the at least one solid-state synthetic method.

2. The synthesis machine according to claim 1 , wherein the at least one solid-state synthetic method from the viable subset of the multiplicity of possible synthetic reactions includes at least one recommended synthesis with a calculated nucleation barrier metric and a competition metric that resides at or near an origin of a plot of the nucleation barrier metric versus the competition metric or is on or near a pareto frontier of the plot for the target inorganic material input by a user, and wherein each of the at least one recommended synthesis is separately input to the synthesis machine for syntheses.

3. The synthesis machine according to claim 1 , wherein the computer program comprises at least one interface for input of the target inorganic material by a user and/or by an inputting computer program.

4. The synthesis machine according to claim 1 , wherein the delivery mechanism is computer controlled.

5. The synthesis machine according to claim 1 , wherein the delivery mechanism comprises one or more of a powder dispensing technique, pipetting technique, ink-jet printing technique, spray pyrolysis technique, laser ablation technique, thermal evaporation technique; doping technique, chemical vapor deposition technique and gas flowing technique.

6. The synthesis machine according to claim 1 , wherein the controller is coordinated with the synthesis planning module and imposes one or more reaction conditions according to the synthesis planner module with a signal imposed upon one or more of a heater, chiller, pressurizer, vacuum pump, and irradiators of laser, infrared, visible, or ultraviolet radiation.

7. The synthesis machine according to claim 1 , wherein the controller coordinates monitoring of at least one in-situ probe of a thermistor, thermocouple, pressure gauge, balance, and an infrared camera attached to the reaction vessel, wherein a temperature, pressure, reaction mass, and visual depiction of a reaction mixture in the vessel are output to the processor.

8. The synthesis machine according to claim 1 , wherein the controller coordinates monitoring one or more of temperature, pressure, mass, and ex-situ probes including diffractometers (such as an X-ray diffractometer), spectroscopic devices (such as an energy-dispersive spectroscopy device or X-ray fluorescence spectroscopy), calorimetric scanners (such as a differential scanning calorimetry), and optical or electron microscopes, results of which are output to synthesis planner's coupled processor.

9. The synthesis machine according to claim 1 , further comprising a robotic sample transporter coupled to the controller for transporting a defined amount of a reaction mixture to one or more an ex-situ probe selected from a diffractometer, spectroscopic device, calorimetric scanner, optical microscope, or electron microscope.

10. A synthesis machine for preparation of a target inorganic material, comprising:
a synthesis planner module coupled with a processor that outputs from a synthesis route recommendation computer program:
at least one solid-state synthetic method for the preparation of the target inorganic material, where the at least one solid-state synthetic method comprises a viable subset of a multiplicity of possible synthetic reactions;
at least one recommended synthesis from the at least one solid-state method, the at least one recommended synthesis being a synthesis with a calculated nucleation barrier metric and a competition metric that resides at or near an origin of a plot of the nucleation barrier metric versus the competition metric or is on or near a pareto frontier of the plot for the target inorganic material input by a user, and wherein the at least one recommended synthesis is separately input to the synthesis machine for syntheses;

at least one reaction vessel for containment of at least one reactant for formation of the target inorganic material, wherein each reaction vessel is for the performance of a single recommended synthesis under a first stoichiometry and a first set of conditions contained in the output of the computer program, or as an enumerated stoichiometry and enumerated set of conditions modified according to a result of a previous preparation of the target inorganic material by the synthesis machine, ultimately resulting from the first stoichiometry and a first set of conditions;
at least one delivery mechanism to provide a plurality of reactants to the reaction vessel, wherein a quantity of each of the plurality of reactants is provided at the first stoichiometry or in the enumerated stoichiometry;
at least one controller configured for:
controlling the first set of conditions or the enumerated set of conditions required for the at least one recommended synthesis;
monitoring the first set of conditions or the enumerated set of conditions during the at least one recommended synthesis; and
evaluating a progress of a reaction of the at least one recommended synthesis.

11. The synthesis machine according to claim 10 , wherein the computer program comprises at least one interface for input of the target inorganic material by a user and/or by an inputting computer program.

12. The synthesis machine according to claim 10 , wherein the delivery mechanism is computer controlled.

13. The synthesis machine according to claim 10 , wherein the delivery mechanism comprises one or more of a powder dispensing technique, pipetting technique, ink-jet printing technique, spray pyrolysis technique, laser ablation technique, thermal evaporation technique; doping technique, chemical vapor deposition technique, and gas flowing technique.

14. The synthesis machine according to claim 10 , wherein the controller is coordinated with the synthesis planning module and imposes one or more reaction conditions according to the synthesis planner module with a signal imposed upon one or more of a heater, chiller, pressurizer, vacuum pump, and irradiators of laser, infrared, visible, or ultraviolet radiation.

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Assignees

• Toyota Res Inst Inc

Inventors

• Aykol Muratahan
• Suram Santosh K

Classifications

• B01J19/0013

  Controlling the temperature of the process · CPC title

• G16C20/90

  Programming languages; Computing architectures; Database systems; Data warehousing · CPC title

• B01J2219/00009

  Pilot-scale plants · CPC title

• G16C20/10 Primary

  Analysis or design of chemical reactions, syntheses or processes · CPC title

• B01J2219/00227

  modifying the operating conditions · CPC title