Device and method for nuclear magnet resonance spectroscopy

Patent metadata

Field	Value
Publication number	US-11609292-B2
Application number	US-202117224320-A
Country	US
Kind code	B2
Filing date	Apr 7, 2021
Priority date	Apr 14, 2020
Publication date	Mar 21, 2023
Grant date	Mar 21, 2023

Abstract

A device for NMR spectroscopy includes a magnet arrangement, configured to produce a magnetic probe field within a magnet field of view external to the magnet arrangement. In a embodiment, the device includes a coil arrangement, configured to generate an electromagnetic excitation field within a coil field of view and a controller, configured to control the coil arrangement. The device includes a magnet adjustment arrangement, configured and arranged to modify at least one parameter of the magnet arrangement to change a spatial position of the magnet field of view.

First claim

What is claimed is:

1. A device for nuclear magnetic resonance spectroscopy, the device comprising:
a magnet arrangement, configured to produce a magnetic probe field within a magnet field of view external to the magnet arrangement;
a coil arrangement, configured to generate an electromagnetic excitation field within a coil field of view;
a controller, configured to control the coil arrangement; and
a magnet adjustment arrangement, configured and arranged to modify at least one parameter of the magnet arrangement to change a spatial position of the magnet field of view.

2. The device of claim 1 , wherein at least one of
the magnet arrangement comprises one or more magnet components, and the magnet adjustment arrangement is configured to modify at least one of a position or an orientation of at least one of the one or more magnet components to change the spatial position of the magnet field of view; or
the magnet arrangement comprises an electromagnet, and the magnet adjustment arrangement is configured to modify a current through the electromagnet to change the spatial position of the magnet field of view.

3. The device of claim 1 , wherein the magnet arrangement comprises at least two magnet components, and the magnet adjustment arrangement is configured to modify at least one of a relative position or a relative orientation of the at least two magnet components with respect to each other to change the spatial position of the magnet field of view.

4. The device of claim 1 , further comprising:
a coil adjustment arrangement, configured and arranged to modify at least one parameter of the coil arrangement to change a spatial position of the coil field of view.

5. The device of claim 4 , wherein the coil arrangement comprises one or more coils, and the coil adjustment arrangement is configured to modify at least one of a position, an orientation or a geometric shape of at least one of the one or more coils to change the spatial position of the coil field of view.

6. The device of claim 1 , further comprising:
an ultrasonic sensor system with an ultrasonic field of view, the ultrasonic sensor system being mechanically coupled to the magnet arrangement to ensure a fixed spatial relation between the ultrasonic field of view and the magnet field of view.

7. The device of claim 1 , further comprising:
an ultrasonic sensor system with an ultrasonic field of view; and
a monitoring system, configured to determine a spatial relation between the ultrasonic sensor system and the magnet arrangement.

8. The device of claim 7 , further comprising:
an ultrasonic adjustment arrangement, configured and arranged to adjust the spatial relation between the ultrasonic sensor system and the magnet arrangement to ensure a fixed spatial relation between the ultrasonic field of view and the magnet field of view.

9. The device of claim 6 , wherein the controller is configured to control the ultrasonic sensor system and the coil arrangement to carry out an ultrasonic assisted magnetic resonance spectroscopy.

10. The device of claim 2 , wherein the magnet arrangement comprises at least two magnet components, and the magnet adjustment arrangement is configured to modify at least one of a relative position or a relative orientation of the at least two magnet components with respect to each other to change the spatial position of the magnet field of view.

11. The device of claim 2 , further comprising:
a coil adjustment arrangement, configured and arranged to modify at least one parameter of the coil arrangement to change a spatial position of the coil field of view.

12. The device of claim 11 , wherein the coil arrangement comprises one or more coils, and the coil adjustment arrangement is configured to modify at least one of a position, an orientation or a geometric shape of at least one of the one or more coils to change the spatial position of the coil field of view.

13. The device of claim 2 , further comprising:
an ultrasonic sensor system with an ultrasonic field of view, the ultrasonic sensor system being mechanically coupled to the magnet arrangement to ensure a fixed spatial relation between the ultrasonic field of view and the magnet field of view.

14. The device of claim 2 , further comprising:
an ultrasonic sensor system with an ultrasonic field of view; and
a monitoring system, configured to determine a spatial relation between the ultrasonic sensor system and the magnet arrangement.

15. A method for nuclear magnetic resonance spectroscopy, the method comprising:
adjusting at least one of
a magnet field of view of a magnet arrangement of a device for nuclear magnetic resonance spectroscopy, the magnet field of view being external to the magnet arrangement, or
a coil field of view of a coil arrangement of the device, wherein
the adjusting achieves a first joint field of view given by an overlapping volume of the magnet field of view and the coil field of view; and

acquiring first magnetic resonance data regarding an object, according to the first joint field of view.

16. The method of claim 15 , further comprising:
changing at least one of the magnet field of view or the coil field of view to achieve a second joint field of view given by the overlapping volume of the magnet field of view and the coil field of view; and
acquiring second magnetic resonance data regarding the object according to the second joint field of view.

17. The method of claim 16 , further comprising:
interpolating the first magnetic resonance data and the second magnetic resonance data to determine virtual magnetic resonance data for a spatial region between the first joint field of view and the second joint field of view.

18. The method of claim 16 , further comprising:
applying, after the acquiring of the first magnetic resonance data, a contrast agent to the object;
acquiring, after the applying of the contrast agent, third magnetic resonance data regarding the object, according to the first joint field of view; and
determining, based on a comparison of the first magnetic resonance data to the third magnetic resonance data, to what extent a part of the object within the first joint field of view has received the contrast agent.

19. The method of claim 17 , further comprising:
applying, after the acquiring of the first magnetic resonance data, a contrast agent to the object;
acquiring, after the applying of the contrast agent, third magnetic resonance data regarding the object, according to the first joint field of view; and
determining, based on a comparison of the first magnetic resonance data to the third magnetic resonance data, to what extent a part of the object within the first joint field of view has received the contrast agent.

20. The method of claim 15 , further comprising:
applying, after the acquiring of the first magnetic resonance data, a contrast agent to the object;
acquiring, after the applying of the contrast agent, second magnetic resonance data regarding the object, according to the first joint field of view; and
determining, based on a comparison of the first magnetic resonance data to the second magnetic resonance data, to what extent a part of the object within the first joint field of view has received the contrast agent.

21. The method of claim 15 , wherein the acquiring of the first magnetic resonance data includes controlling the coil arrangement according to a free induction decay, FID, sequence or according to a spin-echo FID sequence.

22. T

Assignees

• Siemens Healthcare Gmbh

Inventors

• De Oliveira Andre
• Greiser Andreas
• Speier Peter
• Thomas Adrian Mark

Classifications

• G01R33/381 Primary

  using electromagnets · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/383

  using permanent magnets · CPC title

• G01R33/34007

  Manufacture of RF coils, e.g. using printed circuit board technology; additional hardware for providing mechanical support to the RF coil assembly or to part thereof, e.g. a support for moving the coil assembly relative to the remainder of the MR system · CPC title

• G01R33/4633 Primary

  Sequences for multi-dimensional NMR · CPC title