Method for detecting a radical compound derived from a lipid and a compound derived from the radical compound

US11609238B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11609238-B2
Application numberUS-201815965096-A
CountryUS
Kind codeB2
Filing dateApr 27, 2018
Priority dateApr 28, 2017
Publication dateMar 21, 2023
Grant dateMar 21, 2023

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

[Problem] To provide a method of scavenging an unstable radical derived from a lipid and analyzing structures of those radicals.[Means for solution] A fluorescent nitroxide (NBD-Pen) is made to act to scavenge a lipid radical or a fragment radical thereof, and fluorescent detection liquid chromatography (LC/FL) and mass spectrometry (MS) are combined to identify lipid-derived radicals contained in a lipid extract.

First claim

Opening claim text (preview).

The invention claimed is: 1. A compound, which is the following compound (C′): wherein R is selected from a group consisting of CH 3 , C 2 H 5 , C 3 H 7 , C 4 H 9 , C 6 H 13 , C 7 H 13 , C 7 H 13 O, C 8 H 15 O, C 9 H 15 , C 9 H 15 O 2 , C 9 H 13 O 3 , C 10 H 17 O, C 11 H 19 O 2 , and C 12 H 21 O 2 ; or R is selected from a group consisting of AA-O 2 , CH 3 , C 2 H 5 , C 3 H 7 , C 4 H 9 , C 6 H 13 , C 6 H 9 O 3 , C 7 H 13 , C 7 H 13 O, C 8 H 13 O 2 , C 8 H 15 O, C 9 H 17 , C 9 H 15 O 2 , C 9 H 13 O 3 , C 10 H 17 O, C 11 H 19 , C 11 H 17 O, C 11 H 19 O, C 11 H 19 O 2 , C 12 H 19 O, C 12 H 19 O 2 , C 13 H 19 O 2 , C 14 H 21 O, C 14 H 23 O, and C 15 H 23 O, and wherein AA represents arachidonic acid; or R is selected from a group consisting of ALA-O 2 , CH 3 , C 5 H 9 O, C 6 H 9 O, C 6 H 11 O, C 7 H 11 O, C 8 H 13 , C 8 H 11 O, C 8 H 11 O 3 , C 8 H 13 O, C 9 H 13 O, C 9 H 13 O 2 , C 10 H 15 O, C 11 H 17 , C 11 H 15 O, C 11 H 17 O, C 11 H 15 O 3 , C 15 H 21 O 2 , and C 15 H 21 O 3 and, wherein ALA represents α-linolenic acid; or R is selected from a group consisting of EPA-O 2 , CH 3 , C 5 H 9 O, C 6 H 9 O, C 6 H 11 O, C 7 H 11 O, C 8 H 13 , C 8 H 11 O, C 8 H 11 O 3 , C 8 H 13 O, C 9 H 13 O, C 9 H 13 O 2 , C 10 H 15 O, C 11 H 17 , C 11 H 15 O, C 11 H 17 O, C 11 H 15 O 3 , C 12 H 17 O, C 12 H 17 O 2 , C 14 H 21 O, C 14 H 19 O, C 15 H 21 O, C 15 H 21 O 2 , C 15 H 21 O 3 , C 17 H 23 O, and C 18 H 25 O and, wherein EPA represents eicosapentaenoic acid; or R is selected from a group consisting of DHA-O 2 , CH 3 , C 5 H 9 O, C 6 H 9 O, C 6 H 11 O, C 7 H 11 O, C 8 H 13 , C 8 H 11 O, C 8 H 11 O 3 , C 8 H 13 O, C 9 H 13 O, C 9 H 13 O 2 , C 10 H 15 O, C 11 H 17 , C 11 H 15 O, C 11 H 17 O, C 11 H 15 O 3 , C 12 H 17 O, C 12 H 17 O 2 , C 14 H 21 O, C 14 H 19 O, C 15 H 21 O, C 15 H 21 O 2 , C 15 H 21 O 3 , C 17 H 23 O, C 18 H 25 O, and C 21 H 31 O 4 and, wherein DHA represents docosahexaenoic acid. 2. The compound of claim 1 , wherein R is selected from a group consisting of C 7 H 13 , C 7 H 13 O, C 8 H 15 O, C 9 H 15 , C 9 H 15 O 2 , C 9 H 13 O 3 , C 10 H 17 O, C 11 H 19 O 2 , and C 12 H 21 O 2 ; or R is selected from a group consisting of AA-O 2 , C 6 H 9 O 3 , C 7 H 13 , C 7 H 13 O, C 8 H 13 O 2 , C 8 H 15 O, C 9 H 17 , C 9 H 15 O 2 , C 9 H 13 O 3 , C 10 H 17 O, C 11 H 19 , C 11 H 17 O, C 11 H 19 O, C 11 H 19 O 2 , C 12 H 19 O, C 12 H 19 O 2 , C 13 H 19 O 2 , C 14 H 21 O, C 14 H 23 O, and C 15 H 23 O, and wherein AA represents arachidonic acid; or R is selected from a group consisting of ALA-O 2 , C 5 H 9 O, C 6 H 9 O, C 6 H 11 O, C 7 H 11 O, C 8 H 13 , C 8 H 11 O, C 8 H 11 O 3 , C 8 H 13 O, C 9 H 13 O, C 9 H 13 O 2 , C 10 H 15 O, C 11 H 17 , C 11 H 15 O, C 11 H 17 O, C 11 H 15 O 3 , C 15 H 21 O 2 , and C 15 H 21 O 3 and, wherein ALA represents α-linolenic acid; or R is selected from a group consisting of EPA-O 2 , C 5 H 9 O, C 6 H 9 O, C 6 H 11 O, C 7 H 11 O, C 8 H 13 , C 5 H 11 O, C 8 H 11 O 3 , C 8 H 13 O, C 9 H 13 O, C 9 H 13 O 2 , C 10 H 15 O, C 11 H 17 , C 11 H 15 O, C 11 H 17 O, C 11 H 15 O 3 , C 12 H 17 O, C 12 H 17 O 2 , C 14 H 21 O, C 14 H 19 O, C 15 H 21 O, C 15 H 21 O 2 , C 15 H 21 O 3 , C 17 H 23 O, and C 18 H 25 O and, wherein EPA represents eicosapentaenoic acid; or R is selected from a group consisting of DHA-O 2 , C 5 H 9 O, C 6 H 9 O, C 6 H 11 O, C 7 H 11 O, C 8 H 13 , C 5 H 11 O, C 8 H 11 O 3 , C 8 H 13 O, C 9 H 13 O, C 9 H 13 O 2 , C 10 H 15 O, C 11 H 17 , C 11 H 15 O, C 11 H 17 O, C 11 H 15 O 3 , C 12 H 17 O, C 12 H 17 O 2 , C 14 H 21 O, C 14 H 19 O, C 15 H 21 O, C 15 H 21 O 2 , C 15 H 21 O 3 , C 17 H 23 O, C 18 H 25 O, and C 21 H 31 O 4 and, wherein DHA represents docosahexaenoic acid.

Assignees

Inventors

Classifications

  • Sources of fatty acids, e.g. natural glycerides, characterised by the nature, the quantities or the distribution of said acids · CPC title

  • G01N33/92Primary

    involving lipids, e.g. cholesterol {, lipoproteins, or their receptors (steroid hormones G01N33/743)} · CPC title

  • condensed with carbocyclic rings or ring systems · CPC title

  • linked by a chain containing hetero atoms as chain links · CPC title

  • with fluorescent label · CPC title

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What does patent US11609238B2 cover?
[Problem] To provide a method of scavenging an unstable radical derived from a lipid and analyzing structures of those radicals.[Means for solution] A fluorescent nitroxide (NBD-Pen) is made to act to scavenge a lipid radical or a fragment radical thereof, and fluorescent detection liquid chromatography (LC/FL) and mass spectrometry (MS) are combined to identify lipid-derived radicals contained…
Who is the assignee on this patent?
Yamada Ken Ichi, Fuso Pharmaceutical Ind, Ken Ichi Yamada
What technology area does this patent fall under?
Primary CPC classification G01N33/92. Mapped technology areas include Physics.
When was this patent published?
Publication date Tue Mar 21 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).