Carbon nanotube-functionalized reverse thermal gel and methods of forming and using same

Patent metadata

Field	Value
Publication number	US-11608407-B2
Application number	US-201816649560-A
Country	US
Kind code	B2
Filing date	Sep 19, 2018
Priority date	Sep 20, 2017
Publication date	Mar 21, 2023
Grant date	Mar 21, 2023

Abstract

Polymers suitable for forming carbon nanotube-functionalized reverse thermal gel compositions, compositions including the polymers, and methods of forming and using the polymers and compositions are disclosed. The compositions have reverse thermal gelling properties and transform from a liquid/solution to a gel—e.g., near or below body temperature. The polymers and compositions can be injected into or proximate an area in need of treatment.

First claim

We claim:

1. A method of forming a carbon nanotube-functionalized reverse thermal gel composition, the method comprising the steps of:
synthesizing multi-walled carbon nanotubes with COOH groups;
synthesizing a reverse thermal gel polymer backbone;
conjugating poly-L-lysine onto the polymer backbone; and
conjugating at least one of the carbon nanotubes onto the L-lysine.

2. The method of claim 1 , further comprising a step of conjugating another poly-L-lysine onto the at least one of the carbon nanotubes.

3. The method of claim 1 , wherein the step of synthesizing a reverse thermal gel polymer backbone comprises reacting N—BOC-serinol, urea, and a diisocyanate to form PSHU.

4. The method of claim 1 , wherein the step of synthesizing a reverse thermal gel polymer backbone comprises reacting NIPAAm and a carboxylic acid to form PNIPAAm-COOH.

5. The method of claim 1 , wherein the step of synthesizing a reverse thermal gel polymer backbone comprises conjugating PNIPAAm-COOH and PSHU—NH 2 .

6. The method of claim 1 , further comprising a step of forming a dispersion comprising the carbon nanotubes with a COOH group in a solvent.

Assignees

• Univ Colorado Regents
• Univ Degli Studi Di Trieste
• Univ Colorado Regents

Inventors

• Park Daewon
• Pena Castellanos Brisa
• Bosi Susanna
• Mestroni Luisa
• Prato Maurizio

Classifications

• C08G18/771

  oxygen · CPC title

• C01B2202/28

  Solid content in solvents · CPC title

• C08G18/3829

  containing ureum groups · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• C01B2202/06

  Multi-walled nanotubes · CPC title