Flow balancing devices, methods, and systems

Patent metadata

Field	Value
Publication number	US-11607482-B2
Application number	US-202017122772-A
Country	US
Kind code	B2
Filing date	Dec 15, 2020
Priority date	Jul 18, 2016
Publication date	Mar 21, 2023
Grant date	Mar 21, 2023

Abstract

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

First claim

The invention claimed is:

1. A method for controlling fluid flow in a fluid circuit, comprising:
providing a blood treatment device having a blood compartment and a non-blood compartment separated from each other by a membrane;
connecting a first inflow line and a first outflow line to one of the blood and the non-blood compartments of the blood treatment device;
connecting a second inflow line and a second outflow line to the other of the blood and the non-blood compartments of the blood treatment device;
using a controller, regulating a speed of a first inflow pump fluidly connected to the first inflow line, to establish a flow into said one of the blood and the non-blood compartments of the blood treatment device;
using the controller, regulating a speed of a first outflow pump fluidly connected to the first outflow line to establish a flow out of said one of the blood and the non-blood compartments of the blood treatment device;
detecting a pressure of at least one of the blood and the non-blood compartments, said pressure indicating a magnitude of a difference between rates of the flows into and out of said one of the blood and the non-blood compartments;
during said detecting, blocking a flow of fluid through the second inflow and outflow lines such that the first inflow and outflow lines and said one of the blood and the non-blood compartments of the blood treatment device constitute a fixed volume fluid channel;
calculating a flow control parameter responsively to said pressure; and
thereafter regulating a net transfer of fluid between the blood and the non-blood compartments responsively to the control parameter.

2. The method of claim 1 , further comprising, during said detecting, flowing fluid through the second inflow and outflow lines.

3. The method of claim 1 , wherein the pressure indicates a magnitude of a transmembrane transport between the blood and the non-blood compartments.

4. The method of claim 1 , wherein the pressure indicates a magnitude of a transmembrane transport between the blood and the non-blood compartments and the calculating includes comparing the pressure to a predefined threshold pressure indicative of zero magnitude of the transmembrane transport between the blood and the non-blood compartments.

5. The method of claim 1 , wherein the pressure indicates a magnitude of a transmembrane transport between the blood and the non-blood compartments;
the calculating includes comparing the pressure to a predefined threshold pressure indicative of zero magnitude of the transmembrane transport between the blood and the non-blood compartments; and
the method further includes determining the predefined threshold pressure by detecting a pressure of the at least one of the blood and the non-blood compartments while blocking transport between the blood and the non-blood compartments.

6. The method of claim 1 , wherein the pressure indicates a magnitude of a transmembrane transport between the blood and the non-blood compartments;
the calculating includes comparing the pressure to a predefined threshold pressure indicative of zero magnitude of the transmembrane transport between the blood and the non-blood compartments; and
the method further includes determining the predefined threshold pressure by detecting a pressure of the at least one of the blood and the non-blood compartments while blocking transport between the blood and the non-blood compartments and while establishing flow through the second inflow and outflow lines at a predefined flow rate.

7. The method of claim 1 , wherein the controller includes an embedded computer with a data store having instructions readable thereby to regulate, detect, and calculate and to store data responsive thereto.

8. The method of claim 1 , wherein the control parameter includes a constant of proportionality that relates a command speed of a slave pump to a command speed of a master pump coinciding with identical flow rates therethrough.

9. The method of claim 1 , wherein the controller adjusts the first outflow pump in response to a predefined ultrafiltration flow rate and said control parameter such that the first outflow pump generates a flow rate that is higher than that of the first inflow pump.

10. The method of claim 1 , wherein the controller continuously updates a speed of the first outflow pump in response to a signal from the detected pressure.

11. The method of claim 1 , wherein the detected pressure of at least one of the blood and the non-blood compartments is indicated by at least one of a pressure in the first inflow line and a pressure in the first outflow line.

12. The method of claim 11 , wherein the pressure of at least one of the blood and the non-blood compartments is an average of the pressure in the first inflow line and the pressure in the first outflow line.

13. The method according to claim 1 , wherein the detecting the pressure of at least one of the blood and the non-blood compartments is detecting the pressure of the blood compartment.

14. A method for controlling flow in a blood treatment fluid circuit, the method comprising:
pumping fluid serially through first fluid lines connected to second fluid lines through a blood treatment device while blocking flow through the second fluid lines;
the pumping including, using a controller to control speeds of pumping actuators, each of the pumping actuators determining a flow rate through a respective one of the first fluid lines;
the first fluid lines being one of blood lines and treatment fluid lines and the second lines being the other of blood lines and treatment fluid lines;
using the controller, detecting sensor data indicating a difference between said flow rates in the first fluid lines as well as speed data indicating a speed of at least one of the pumping actuators;
using the controller, calculating one or more control parameters from said speed and sensor data, the one or more control parameters indicating said speed of said at least one of the pumping actuators for which said difference is below a predefined threshold; and
using the controller, regulating a net transfer of fluid through a pair of the first fluid lines to, or from, the blood treatment device by regulating the speeds of said at least one of the pumping actuators responsively to said one or more control parameters.

15. The method of claim 14 , wherein the detecting and calculating are performed during a synchronization mode and said regulating is performed during a treatment mode.

16. The method of claim 14 , wherein the calculating includes feedback controlling the at least one of the pumping actuators responsively to the sensor data to achieve a target magnitude indicated by said sensor data.

17. The method of claim 14 , wherein said sensor data is from a digitized pressure sensor signal, the pressure sensor indicating the pressure inside the blood treatment device.

18. The method of claim 14 , wherein said second fluid lines are blood lines of a hemodialysis fluid circuit.

19. The method of claim 18 , wherein the blood treatment device is a dialyzer.

20. The method of claim 14 , wherein the regulating includes a net transfer of fluid responsively to both the one or more control parameters and a predefined ultrafiltration rate, such that a net flow from said blood treatment device through said first fluid lines, equal to said predefined ultrafiltration rate, is established.

Assignees

• Nxstage Medical Inc

Inventors

• Desouza David
• Rubery Jr Daniel Joseph
• Treu Dennis M
• Wyeth Mark T
• James Jerome
• Casey Garrett D
• Brugger James M
• Schnell William J
• Burbank Jeffrey H
• Friederichs Goetz

Classifications

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M1/14

  Dialysis systems; Artificial kidneys; Blood oxygenators (semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00){; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis} · CPC title

• A61M1/1601 Primary

  Control or regulation · CPC title

• A61M2205/50

  with microprocessors or computers · CPC title

• A61M1/1647 Primary

  with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser · CPC title