Particle and method of producing the particle

Patent metadata

Field	Value
Publication number	US-11597787-B2
Application number	US-202017073666-A
Country	US
Kind code	B2
Filing date	Oct 19, 2020
Priority date	Oct 25, 2019
Publication date	Mar 7, 2023
Grant date	Mar 7, 2023

Abstract

Provided is a particle suitable for a specimen test, which has high sensitization efficiency in a reaction with an antibody, shows high detection sensitivity as a latex reagent, hardly agglutinates during its storage, and hardly causes nonspecific adsorption even when not post-coated. The particle is a particle including a copolymer containing a monomer unit derived from a styrene-based monomer and a monomer unit derived from a glycidyl group-containing monomer, the particle being represented by the following general formula (1):in the general formula (1), L1 represents a copolymer moiety containing the monomer unit derived from the styrene-based monomer and the monomer unit derived from the glycidyl group-containing monomer, “n” represents from 4 to 11, and R1 and R2 each represent a hydrogen atom, an alkyl group, or a halogen.

First claim

What is claimed is:

1. A particle comprising a copolymer containing a monomer unit derived from a styrene-based monomer and a monomer unit derived from a glycidyl group-containing monomer, the particle being represented by the following general formula (1):

in the general formula (1), L 1 represents a copolymer moiety containing the monomer unit derived from the styrene-based monomer and the monomer unit derived from the glycidyl group-containing monomer, “n” represents from 4 to 11, and R 1 and R 2 each represent a hydrogen atom, an alkyl group, or a halogen.

2. The particle according to claim 1 , wherein in the general formula (1), R 1 and R 2 each represent a hydrogen atom.

3. The particle according to claim 1 , wherein the general formula (1) further comprises a site represented by the following general formula (2):

in the general formula (2), * represents a site to be bonded to L 1 of the general formula (1), “m” represents from 2 to 4, and R 3 and R 4 each represent a hydrogen atom.

4. The particle according to claim 1 , wherein the general formula (1) further comprises a site represented by the following general formula (3):

in the general formula (3), ** represents a site to be bonded to L 1 of the general formula (1), “m” represents from 2 to 4, and R 3 and R 4 each represent a hydrogen atom or a hydroxy group.

5. The particle according to claim 1 , wherein the particle is suitable for use in an agglutination method.

6. The particle according to claim 1 , wherein the particle is a latex particle.

7. The particle according to claim 1 , wherein the particle is suitable for use in a specimen test.

8. A method of producing a particle including a copolymer containing a monomer unit derived from a styrene-based monomer and a monomer unit derived from a glycidyl group-containing monomer, the particle being represented by the following general formula (1):

in the general formula (1), L 1 represents a copolymer moiety containing the monomer unit derived from the styrene-based monomer and the monomer unit derived from the glycidyl group-containing monomer, “n” represents from 4 to 11, and R 1 and R 2 each represent a hydrogen atom, an alkyl group, or a halogen,
the method comprising using one of sodium hydroxide and potassium hydroxide to bond a spacer molecule to a glycidyl group, followed by purification of the resultant by one of centrifugal separation and dialysis.

Assignees

• Canon Kk
• Canon Medical Systems Corp

Inventors

• Sekiguchi Takeshi
• Kanazaki Kengo

Classifications

• C08F220/325 Primary

  containing glycidyl radical, e.g. glycidyl (meth)acrylate · CPC title

• C08F6/16

  Purification · CPC title

• C08J2333/14

  of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen · CPC title

• C08J3/05

  from solid polymers · CPC title