Compositions and methods for viral sensitization
US-2024360115-A1 · Oct 31, 2024 · US
US11597699B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11597699-B2 |
| Application number | US-202016853043-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 20, 2020 |
| Priority date | Oct 7, 2005 |
| Publication date | Mar 7, 2023 |
| Grant date | Mar 7, 2023 |
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Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
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We claim: 1. A method of arresting the development of or causing the regression of malignant fibrous histiocytoma, comprising administering to a patient in need thereof a therapeutically effective amount of 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-[(2S)-piperidin-2-yl]azetidin-3-ol or a pharmaceutically acceptable salt thereof.
containing three or more hetero rings · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
linked by a carbon chain containing only aliphatic carbon atoms · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
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