MEK inhibitors and methods of their use

US11597699B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-11597699-B2
Application numberUS-202016853043-A
CountryUS
Kind codeB2
Filing dateApr 20, 2020
Priority dateOct 7, 2005
Publication dateMar 7, 2023
Grant dateMar 7, 2023

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.

First claim

Opening claim text (preview).

We claim: 1. A method of arresting the development of or causing the regression of malignant fibrous histiocytoma, comprising administering to a patient in need thereof a therapeutically effective amount of 1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-[(2S)-piperidin-2-yl]azetidin-3-ol or a pharmaceutically acceptable salt thereof.

Assignees

Inventors

Classifications

  • containing three or more hetero rings · CPC title

  • linked by a chain containing hetero atoms as chain links · CPC title

  • linked by a chain containing hetero atoms as chain links · CPC title

  • linked by a carbon chain containing only aliphatic carbon atoms · CPC title

  • linked by a chain containing hetero atoms as chain links · CPC title

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Frequently asked questions

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What does patent US11597699B2 cover?
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Who is the assignee on this patent?
Exelixis Inc
What technology area does this patent fall under?
Primary CPC classification C07D403/06. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).