Afterload device for ex situ heart perfusion

Patent metadata

Field	Value
Publication number	US-11596147-B2
Application number	US-202016910930-A
Country	US
Kind code	B2
Filing date	Jun 24, 2020
Priority date	Aug 7, 2019
Publication date	Mar 7, 2023
Grant date	Mar 7, 2023

Abstract

The present invention discloses an afterload device for ex situ heart perfusion, which includes an afterload energy storage module, a pressure regulation module and two flow rate regulators that are connected through a conduit. The afterload energy storage module includes a rigid closed container and a flexible container. The perfusion fluid flows into the flexible container from one side thereof through the conduit, and the perfusion fluid flows out from the flexible container at another side thereof as the flexible container is subjected to the action of the medium pressure in the rigid hermetic container. The pressure regulation module includes two pressure regulation valves and a compressible-medium source, for regulating the pressure range within the rigid hermetic container to be always maintained between the set diastolic pressure and the set systolic pressure.

First claim

The invention claimed is:

1. An afterload device for ex situ heart perfusion, comprising an energy storage module, a pressure regulation module and two flow rate regulators, wherein the energy storage module comprises a flexible container and a rigid hermetic container filled with compressible media, the flexible container is placed in the inner cavity of the rigid hermetic container and connected to the two flow rate regulators via a conduit; and the pressure regulation module comprises two pressure regulation valves and a compressible-medium source, wherein the two pressure regulation valves are in communication with the rigid hermetic container, wherein the two pressure regulation valves are respectively a pressure regulation valve I and a pressure regulation valve II, and a set pressure value of the pressure regulation valve I is smaller than a set pressure value of the pressure regulation valve II, and the pressure regulation valve I is connected to the compressible-medium source, wherein the rigid hermetic container is provided with two interfaces thereon, and the two interfaces are connected to the pressure regulation valve I and the pressure regulation valve II through a pneumatic joint I and a pneumatic joint II, respectively.

2. The afterload device for ex situ heart perfusion according to claim 1 , wherein the flexible container comprises at least has two interfaces, and the two interfaces are respectively sealingly connected to two openings on the rigid hermetic container through a conduit.

3. The afterload device for ex situ heart perfusion according to claim 2 , wherein the two flow rate regulators located outside the rigid hermetic container are respectively installed on an inlet conduit and an outflow conduit, and the inlet conduit and the outflow conduit are connected to the two interfaces of the flexible container through a joint I and a joint II, respectively.

4. The afterload device for ex situ heart perfusion according to claim 1 , wherein a set pressure of the pressure regulation valve I is a diastolic pressure, and a set pressure of the pressure regulation valve II is a systolic pressure.

5. The afterload device for ex situ heart perfusion according to claim 4 , wherein the other end of the pressure regulation valve I is connected to the compressible medium source for introducing a compressible medium into the rigid hermetic container, and the other end of the pressure regulation valve II is connected to the atmosphere.

6. The afterload device for ex situ heart perfusion according to claim 5 , wherein when the pressure in the rigid hermetic container is less than the set diastolic pressure, the pressure regulation valve I is opened to discharge the compressible medium from the compressible-medium source into the rigid hermetic container; and when the pressure in the rigid hermetic container is greater than the set systolic pressure, the pressure regulation valve II is opened to discharge the compressible medium in the rigid hermetic container, so as to reduce the pressure.

Assignees

• Univ Shanghai

Inventors

• Peng Yan
• Xu Zhibing
• Xin Liming
• Luo Jun
• Xie Shaorong
• Pu Huayan
• Gao Shouwei
• Badiwala Mitesh
• Sun Yu

Classifications

• A01N1/148

  with provisions specially adapted for transporting · CPC title

• A01N1/143 Primary

  for organ perfusion · CPC title

• A01N1/0273

  Human Necessities · mapped topic

• A01N1/0247 Primary

  Human Necessities · mapped topic