Anti-freezing agent for protecting biological tissue during freezing treatment and preparation method therefor
US-11160271-B2 · Nov 2, 2021 · US
Anti-freezing agent for protecting biological tissue during freezing treatment and preparation method therefor
US11596145B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11596145-B2 |
| Application number | US-202117397506-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 9, 2021 |
| Priority date | Sep 30, 2016 |
| Publication date | Mar 7, 2023 |
| Grant date | Mar 7, 2023 |
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- Title
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Abstract
Official abstract text for this publication.
Disclosed are an anti-freezing agent for protecting a biological tissue from being damaged during a freezing treatment and a preparation method therefor. The method for preparing the anti-freezing agent involves mixing ethylene glycol, water and dimethylsulfoxide homogeneously to form a matrix, and then slowly adding sodium polyacrylate. The prepared anti-freezing agent is coated onto biological tissue during a freezing treatment such that damage to the biological tissue is reduced.
First claim
Opening claim text (preview).
What is claimed is: 1. A method for protecting a biological tissue of a human or animal during a freezing treatment, comprising applying an anti-freezing agent to the biological tissue to protect the biological tissue from being damaged during the freezing treatment; wherein the anti-freezing agent is prepared by the following steps: (1) mixing ethylene glycol and water to form an aqueous ethylene glycol solution, and then adding dimethyl sulfoxide into the aqueous ethylene glycol solution and mixing uniformly to form a matrix, wherein a weight ratio of ethylene glycol to water is about 1:1 to 3:1, and a weight ratio of dimethyl sulfoxide to the aqueous ethylene glycol solution is about 1:10 to 2:10; and (2) heating the matrix slowly and then adding sodium polyacrylate into the heated matrix, which is then stirred uniformly and cooled to room temperature to obtain the anti-freezing agent, wherein a weight ratio of the matrix to sodium polyacrylate is 4:1 to 10:1. 2. The method of claim 1 , wherein the biological tissue of the human or animal is cartilage, tendon or ligament. 3. The method of claim 1 , wherein the biological tissue of a human or animal is cartilage, tendon or ligament of an autologous bone with tumor cells from a patient with bone tumor, comprising the following steps: (1) taking an autologous bone with tumor cells from a patient with bone tumor, and (2) killing the tumor cells of the autologous bone by a freezing treatment, and protecting the autologous bone with the anti-freezing agent.
Assignees
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Classifications
- A01N1/125Primary
Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators · CPC title
Compresses or poultices for effecting heating or cooling · CPC title
- A01N1/0221Primary
Human Necessities · mapped topic
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- What does patent US11596145B2 cover?
- Disclosed are an anti-freezing agent for protecting a biological tissue from being damaged during a freezing treatment and a preparation method therefor. The method for preparing the anti-freezing agent involves mixing ethylene glycol, water and dimethylsulfoxide homogeneously to form a matrix, and then slowly adding sodium polyacrylate. The prepared anti-freezing agent is coated onto biologica…
- Who is the assignee on this patent?
- Taipei Veterans General Hospital
- What technology area does this patent fall under?
- Primary CPC classification A01N1/125. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Mar 07 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).