Biodegradable iron-containing compositions, methods of preparing and applications therefor

Patent metadata

Field	Value
Publication number	US-11590266-B2
Application number	US-201916559810-A
Country	US
Kind code	B2
Filing date	Sep 4, 2019
Priority date	Oct 5, 2012
Publication date	Feb 28, 2023
Grant date	Feb 28, 2023

Abstract

The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular.

First claim

The invention claimed is:

1. A biodegradable iron-based metal alloy, consisting of:
from 0.04 to 0.79 weight percent magnesium;
from 27.79 to 27.98 weight percent zirconium;
from 0.64 to 0.65 weight percent calcium; and
a remainder of iron,
wherein the metal alloy is biodegradable and structurally amorphous.

2. A biodegradable medical device comprising the iron-based alloy of claim 1 .

3. The device of claim 2 , wherein said device is selected from the group consisting of plate, mesh, staple, screw, pin, tack, rod, suture anchor, tubular mesh, coil, x-ray marker, catheter, pipe, shield, bolt, clip, plug, dental implant, graft device, endoprosthesis, bone-fracture healing device, bone replacement device, joint replacement device, tissue regeneration device, cardiovascular stent, nerve guide, surgical implant, surgical wire and combinations thereof.

4. The device of claim 2 , wherein said device is an implantable device.

5. The device of claim 4 , wherein the implantable device is selected from the group consisting of an orthopedic device, a craniofacial device and a cardiovascular device.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Kumta Prashant N
• Chung Sung Jae
• Saha Partha
• Velikokhatnyi Oleg
• Datta Moni Kanchan
• Hong Dae Ho
• Chou Da-Tren

Classifications

• C22C38/04

  containing manganese · CPC title

• A61L31/022 Primary

  Metals or alloys · CPC title

• C22C38/002

  containing In, Mg, or other elements not provided for in one single group C22C38/001 - C22C38/60 · CPC title

• C22C45/02

  with iron as the major constituent · CPC title

• A61L31/148

  Materials at least partially resorbable by the body · CPC title