Pharmaceutical composition for preventing or treating adverse drug reactions by statin

Patent metadata

Field	Value
Publication number	US-11590150-B2
Application number	US-201816761764-A
Country	US
Kind code	B2
Filing date	Nov 5, 2018
Priority date	Nov 6, 2017
Publication date	Feb 28, 2023
Grant date	Feb 28, 2023

Abstract

The present disclosure relates to a pharmaceutical composition for preventing or treating statin-induced adverse effects or a pharmaceutical composition for co-administration with statin, the pharmaceutical composition containing, as an active ingredient, at least one selected from the group consisting of an isoprenoid-based compound, zaragozic acid, terbinafine, and ketoconazole. The pharmaceutical composition according to the present disclosure may prevent and/or treat adverse statin effects that can be induced by statin, that is, can be induced at any time by oxisterols present at abnormal levels in the body. The pharmaceutical composition can not only treat but also prevent the adverse effects of various statin therapeutics whose use has recently increased rapidly, and thus it is expected that the pharmaceutical composition can be widely used for various diseases and the utilization thereof can further be increased.

First claim

The invention claimed is:

1. A method for preventing or treating statin-induced adverse drug reactions, the method comprising administering to a subject in need thereof a pharmaceutically effective amount of an isoprenoid-based compound, wherein the isoprenoid-based compound is any one or more selected from the group consisting of farnesyl pyrophosphate, mevalonate, isopentenyl pyrophosphate, and geranylgeranyl pyrophosphate.

2. The method of claim 1 , wherein the statin is any one selected from the group consisting of atorvastatin, rosuvastatin, simvastatin, pitavastatin, pravastatin, fluvastatin, lovastatin, cerivastatin, and mevastatin.

3. The method of claim 1 , wherein the adverse drug reactions are caused by statin administration in a state in which oxysterols produced in vivo by lipopolysaccharides are abnormally increased compared to those in normal people.

4. The method of claim 3 , wherein the adverse drug reactions are caused by damage to any one or more cells selected from the group consisting of kidney tubule cells, nerve cells, and pancreatic cells.

5. The method of claim 4 , wherein a disease caused by the damage to kidney tubule cells is any one selected from the group consisting of acute renal failure, acute tubular necrosis injury, and ischemic reperfusion injury.

6. The method of claim 4 , wherein a disease caused by the damage to nerve cells is any one selected from the group consisting of cognitive dysfunction, dementia, Parkinson's disease, Alzheimer's disease, Huntington's syndrome, stroke, and spinal nerve damage.

7. The method of claim 4 , wherein a disease caused by the damage to pancreatic cells is diabetes.

8. The method of claim 3 , wherein oxysterols produced in vivo by lipopolysaccharides are abnormally increased due to the inflammation.

9. The method of claim 1 , further comprising administering a pharmaceutically effective amount of statin to the subject in need thereof.

10. The method of claim 9 , further comprising administering an ezetimibe formulation, a niacin extended-release formulation, or an amlodipine formulation to the subject in need thereof.

11. The method of claim 1 , wherein the adverse drug reactions are damage to kidney tubule cells, nerve cells or pancreatic cells caused by statin administration in a state in which oxysterols produced in vivo by lipopolysaccharides are abnormally increased compared to those in normal people.

12. The method of claim 11 , wherein the oxysterols produced in vivo by lipopolysaccharides are abnormally increased due to inflammation.

Assignees

• Univ Yonsei Iacf

Inventors

• Kim Beom Seok
• Kim Chui Hoon
• Yoon Jong Jin

Classifications

• A61P25/16

  Anti-Parkinson drugs · CPC title

• A61K31/357

  having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel · CPC title

• A61P21/00

  Drugs for disorders of the muscular or neuromuscular system · CPC title

• A61K31/22

  of acyclic acids, e.g. pravastatin · CPC title

• A61K31/40

  having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil · CPC title