Annotation of late potentials comprising local abnormal ventricular activation (LAVA) signals

Patent metadata

Field	Value
Publication number	US-11589795-B2
Application number	US-202017130018-A
Country	US
Kind code	B2
Filing date	Dec 22, 2020
Priority date	Dec 22, 2020
Publication date	Feb 28, 2023
Grant date	Feb 28, 2023

Abstract

A method includes receiving a bipolar signal sensed by a pair of electrodes at a location in a heart of a patient. One or more electrocardiogram (ECG) signals are received, sensed by body-surface electrodes attached to the patient. Two or more successive QRS complexes are identified in the bipolar signal. One or more activations are detected in the bipolar signal, which occur within a window-of-interest that begins at least a given time with respect to the identified QRS complexes. The detected activations are checked whether they are late potentials, by verifying whether (i) the activations do not coincide with a predefined event observed in the ECG signals, and (ii) the activations are repeatable in the successive QRS complexes. In response to deciding that at least one of the detected activations is a late potential, the latest of the at least one of the late potentials is visualized to a user.

First claim

The invention claimed is:

1. A method for annotation of late potentials comprising abnormal ventricular activation signals, comprising:
receiving a bipolar signal sensed by a pair of electrodes at a location in a heart of a patient;
receiving one or more electrocardiogram (ECG) signals sensed by one or more body-surface electrodes attached to the patient;
identifying in the bipolar signal two or more successive QRS complexes;
detecting in the bipolar signal one or more activations occurring within a window-of-interest that begins at least a given time with respect to the identified QRS complexes;
checking whether the one or more detected activations are late potentials, by verifying whether (i) the one or more activations do not coincide with a predefined event observed in the one or more ECG signals, and (ii) the one or more activations are repeatable in the successive QRS complexes; and
in response to deciding that at least one of the one or more detected activations is a late potential, visualizing the latest of the at least one of the one or more late potentials to a user.

2. The method according to claim 1 , wherein visualizing the latest late potential comprises graphically indicating the latest late potential, in association with the location of the pair of electrodes in the heart, on an electrophysiological (EP) map.

3. The method according to claim 1 , wherein visualizing the latest late potential comprises annotating the latest late potential.

4. The method according to claim 1 , wherein the predefined event comprises an activation seen in the one or more ECG signals.

5. The method according to claim 1 , wherein the predefined event comprises a fractionation split seen in the one or more ECG signals.

6. The method according to claim 1 , wherein verifying whether the one or more activations are repeatable comprises verifying whether the one or more activations reoccur in at least a given number of heart cycles.

7. The method according to claim 6 , wherein verifying whether the one or more activations reoccur comprises using pattern matching.

8. The method according to claim 1 , wherein the latest late potential comprises a local abnormal ventricular activity (LAVA) signal.

9. The method according to claim 1 , wherein detecting the activations comprises applying filtration to smooth the bipolar signal, and detecting in the smoothed bipolar signal one or more activations having an amplitude above a given threshold.

10. The method according to claim 1 , wherein the received bipolar signal comprises a ventricular bipolar signal obtained by catheter electrodes.

11. The method according to claim 1 , and comprising:
receiving a unipolar signal at the location, identifying in the unipolar signal two or more successive QRS complexes;
detecting in the unipolar signal one or more activations occurring within a window-of-interest that begins at least a given time with respect to the identified QRS complexes;
checking whether the one or more detected activations are late potentials, by verifying whether (i) the one or more activations do not coincide with a predefined event observed in the one or more ECG signals, and (ii) the one or more activations are repeatable in the successive QRS complexes; and
in response to deciding that at least one of the one or more detected activations is a late potential, visualizing the latest of the at least one of the one or more late potentials to a user.

12. The method according to claim 1 , wherein checking whether the one or more detected activations are late potentials is performed in real-time.

13. The method according to claim 1 , and comprising modifying parameters used in identifying, detecting, checking, deciding, and visualizing the signal.

14. An apparatus for annotation of late potentials comprising abnormal ventricular activation signals, comprising:
an interface, which is configured to:
receive a bipolar signal sensed by a pair of electrodes at a location in a heart of a patient;
receive one or more electrocardiogram (ECG) signals sensed by one or more body-surface electrodes attached to the patient; and

a processor, which is configured to:
identify in the bipolar signal two or more successive QRS complexes;
detect in the bipolar signal one or more activations occurring within a window-of-interest that begins at least a given time with respect to the identified QRS complexes;
check whether the one or more detected activations are late potentials, by verifying whether (i) the one or more activations do not coincide with a predefined event observed in the one or more ECG signals, and (ii) the one or more activations are repeatable in the successive QRS complexes; and
in response to deciding that at least one of the one or more detected activations is a late potential, visualize the latest of the at least one of the one or more late potentials to a user.

15. The apparatus according to claim 14 , wherein the processor is configured to visualize the latest late potential by graphically indicating the latest late potential, in association with the location of the pair of electrodes in the heart, on an electrophysiological (EP) map.

16. The apparatus according to claim 14 , wherein the processor is configured to visualize the latest late potential by annotating the latest late potential.

17. The apparatus according to claim 14 , wherein the predefined event comprises an activation seen in the one or more ECG signals.

18. The apparatus according to claim 14 , wherein the predefined event comprises a fractionation split seen in the one or more ECG signals.

19. The apparatus according to claim 14 , wherein the processor is configured to verify whether the one or more activations are repeatable by verifying whether the one or more activations reoccur in at least a given number of heart cycles.

20. The apparatus according to claim 19 , wherein the processor is configured to verify whether the one or more activations reoccur, by using pattern matching.

21. The apparatus according to claim 14 , wherein the latest late potential comprises a local abnormal ventricular activity (LAVA) signal.

22. The apparatus according to claim 14 , wherein the processor is configured to detect the activations by applying filtration to smooth the bipolar signal, and detecting in the smoothed bipolar signal one or more activations having an amplitude above a given threshold.

23. The apparatus according to claim 14 , wherein the received bipolar signal comprises a ventricular bipolar signal obtained by catheter electrodes.

24. The apparatus according to claim 14 , wherein the interface is further configured to receive a unipolar signal at the location, and wherein the processor is further configured to:
identify in the unipolar signal two or more successive QRS complexes;
detect in the unipolar signal one or more activations occurring within a window-of-interest that begins at least a given time with respect to the identified QRS complexes;
check whether the one or more detected activations are late potentials, by verifying whether (i) the one or more activations do not coincide with a predefined event observed in the one or more ECG signals, and (ii) the one or more activations are repeatable in the successive QRS complexes; and
in response to deciding that at least one of the one or more detected activations is a late potential, visualize the latest of the at least one of the one or more late potentials

Assignees

• Biosense Webster Israel Ltd

Inventors

• Itah Refael
• Katz Natan Sharon
• Kadoshi Yaron
• Hayam Gal
• Nakar Elad
• Bar-On Tal Haim
• Ravuna Eliyahu
• Botzer Lior
• Benaroya Yoav
• Rocha Cortez-Diaz Nuno Miguel

Classifications

• A61B5/00

  Measuring for diagnostic purposes (radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00); Identification of persons · CPC title

• A61B18/12

  by passing a current through the tissue to be heated, e.g. high-frequency current · CPC title

• A61B2018/00005

  Cooling or heating of the probe or tissue immediately surrounding the probe · CPC title

• A61B18/00

  Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body (eye surgery A61F9/007; ear surgery A61F11/00) · CPC title

• A61B5/366 Primary

  Detecting abnormal QRS complex, e.g. widening · CPC title