Near-infrared fluorescent indicators for lysosome and application thereof

Patent metadata

Field	Value
Publication number	US-11584762-B1
Application number	US-202217873248-A
Country	US
Kind code	B1
Filing date	Jul 26, 2022
Priority date	Jul 27, 2021
Publication date	Feb 21, 2023
Grant date	Feb 21, 2023

Abstract

The present disclosure relates to Near-infrared fluorescent indicators for lysosomes and application thereof. These indicators are composed of lipophilic NIR BODIPY derivatives and ionizable bis-tertiary amine moiety, which enable the formation of a transient amphiphilic state in acidic environments specifically. This structural feature affords accurate lysosomal membrane targeting ability at nanomole staining concentration.

First claim

What is claimed is:

1. A compound of formula I:

Wherein, R 1 and R 2 are each independently H, Cl, Br or I;
R 3 is H, CH 3 , CF 3 , C 3 H 6 COOCH 3 , C 2 H 4 COOC 2 H 5 , C 2 H 5 ,

X 1 is

X 2 is H or

Y is each independently

2. A composition targeting or tracking lysosomes comprising a compound of claim 1 .

3. A composition comprising a compound of claim 1 in a solvent, wherein the solvent is selected from the group consisting of water, dimethylformamide, dimethyl acetamide, dimethyl sulfoxide, nitrogen methyl pyrrolidone, and acetonitrile.

Assignees

• Univ Dalian Tech

Inventors

• Zhang Xinfu
• Xiao Yi
• Li Xiangli

Classifications

• C09K11/06

  containing organic luminescent materials · CPC title

• C09B23/04

  one >CH- group, e.g. cyanines, isocyanines, pseudocyanines · CPC title

• C07F5/022 Primary

  without C-boron linkages · CPC title

• C07D517/14 Primary

  Ortho-condensed systems · CPC title

• C07D209/58

  [b]- or [c]-condensed · CPC title