Apparatus and method for determining blood pressure of a subject

Patent metadata

Field	Value
Publication number	US-11583191-B2
Application number	US-201816630900-A
Country	US
Kind code	B2
Filing date	Jul 23, 2018
Priority date	Jul 21, 2017
Publication date	Feb 21, 2023
Grant date	Feb 21, 2023

Abstract

The present invention relates to an apparatus and method for determining blood pressure of a subject. To automatically trigger calibration the apparatus comprises a sensor signal input configured to obtain an arterial pulse wave sensor signal of the subject, a feature extraction unit configured to extract multiple features from the obtained arterial pulse wave sensor signal, an estimation unit configured to determine multiple blood pressure estimation values for individual extracted features and/or groups of extracted features and to determine the subject's blood pressure from said multiple blood pressure estimation values, a calibration unit configured to calibrate the estimation unit based on blood pressure reference measurements, and a calibration trigger unit configured to trigger calibration by the calibration unit if the multiple blood pressure estimation values diverge more than a divergence limit.

First claim

The invention claimed is:

1. An apparatus for determining blood pressure of a subject, comprising:
a sensor signal input configured to obtain an arterial pulse wave sensor signal of the subject;
a feature extraction unit configured to extract multiple features from the obtained arterial pulse wave sensor signal;
an estimation unit configured to determine multiple blood pressure estimation values for one or more extracted features and to determine the subject's blood pressure from said multiple blood pressure estimation values, wherein each of the multiple blood pressure estimation values is associated a corresponding one or more extracted features of the arterial pulse wave sensor signal, and wherein at least a portion of the one or more extracted features are preselected based on one or more data collection studies on the subject;
a calibration unit configured to calibrate, using one or more computer processors, the estimation unit based on blood pressure reference measurements; and
a calibration trigger unit configured to trigger the calibration by the calibration unit if the multiple blood pressure estimation values diverge more than a divergence limit.

2. The apparatus as claimed in claim 1 ,
wherein said calibration trigger unit is configured to determine a feature divergence metric, the feature divergence metric representing a metric for a difference between the multiple blood pressure estimation values.

3. The apparatus as claimed in claim 1 ,
wherein said calibration trigger unit is configured to trigger calibration if an average difference, a maximum difference or a standard deviation of the differences of a predetermined number or all of said multiple blood pressure estimation values exceeds a divergence threshold.

4. The apparatus as claimed in claim 3 , wherein said calibration trigger unit is configured to use a predetermined or time-varying divergence threshold, wherein the time-varying divergence threshold is reduced with time since a last calibration.

5. The apparatus as claimed in claim 1 ,
wherein said estimation unit is configured to determine the subject's blood pressure by taking an average or median of some or all of said multiple blood pressure estimation values.

6. The apparatus as claimed in claim 1 , wherein said estimation unit is configured to determine the subject's blood pressure by taking a weighted average of some or all of said multiple blood pressure estimation values, wherein weights used for said weighted average are determined based on a correlation between the subject's blood pressure and a corresponding feature, wherein said correlation between the subject's blood pressure and a corresponding extracted feature is determined based on the obtained blood pressure reference measurements.

7. The apparatus as claimed in claim 1 ,
wherein said calibration unit is configured to perform, using the one or more computer processors, an initial calibration of the estimation unit for the multiple features and to select a subset of extracted features from the multiple features based on a correlation between a subject's blood pressure and a corresponding feature and
wherein said estimation unit is configured to determine the multiple blood pressure estimation values for individual extracted features and/or groups of extracted features of said subset.

8. The apparatus as claimed in claim 7 ,
wherein said calibration unit is configured to repeat, using the one or more computer processors, a calibration of the estimation unit for some or all extracted features if one or more correlation values of said correlation for one or more features and the subject's blood pressure are below a correlation threshold.

9. The apparatus as claimed in claim 7 ,
wherein said calibration unit is configured to repeat, using the one or more computer processors, the calibration of the estimation unit for some or all extracted features if one or more correlation values of said correlation for one or more features and the subject's blood pressure are below a correlation threshold.

10. A method for determining blood pressure of a subject, comprising:
obtaining an arterial pulse wave sensor signal of the subject;
extracting multiple features from the obtained arterial pulse wave sensor signal;
determining multiple blood pressure estimation values for individual extracted features and/or groups of extracted features;
determining the subject's blood pressure from the multiple blood pressure estimation values, wherein each of the multiple blood pressure estimation values is associated a corresponding one or more extracted features of the obtained arterial pulse wave sensor signal, and wherein at least a portion of the one or more extracted features are preselected based on one or more data collection studies on the subject;
calibrating the determining of the multiple blood pressure estimation values based on blood pressure reference measurements; and
triggering calibration if the multiple blood pressure estimation values diverge more than a divergence limit.

Assignees

• Koninklijke Philips Nv

Inventors

• Schmitt Lars
• Muehlsteff Jens
• Bresch Erik
• Yu Xinchi

Classifications

• A61B5/7221

  Determining signal validity, reliability or quality (preventing, reducing or removing noise induced by motion artefacts A61B5/7207; noise originating from a therapeutic or surgical apparatus A61B5/7217) · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/02108 Primary

  from analysis of pulse wave characteristics · CPC title

• A61B2562/0219

  Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches · CPC title

• A61B2560/0223

  of calibration, e.g. protocols for calibrating sensors · CPC title