Device for determining information relating to a suspected occluding object

Patent metadata

Field	Value
Publication number	US-11583186-B2
Application number	US-201816480001-A
Country	US
Kind code	B2
Filing date	Jan 15, 2018
Priority date	Jan 24, 2017
Publication date	Feb 21, 2023
Grant date	Feb 21, 2023

Abstract

The present invention relates to a device for determining information relating to a suspected occluding structure. It is described to provide ( 210 ) a spectral resolving unit with at least one broadband radiation. The at least one broadband radiation comprises a first broadband radiation acquired from a region of interest within a vascular structure. An occluding structure is suspected to be located within the region of interest and wherein the first broadband radiation is associated with the suspected occluding structure. At least one spectrally resolved data set is determined ( 220 ) on the basis of the at least one broadband radiation, wherein the at least one spectrally resolved data set comprises a first spectrally resolved data set determined on the basis of the first broadband radiation. A processing unit is provided ( 230 ) with the at least one spectrally resolved data set on the basis of the at least one broadband radiation. The processing unit determines ( 240 ) information relating to the suspected occluding structure, comprising utilisation of the first spectrally resolved data set.

First claim

The invention claimed is:

1. A system for determining information relating to an occluding structure, comprising:
at least one optical fiber configured to:
transfer broadband radiation generated by a broadband radiation source to within a vascular structure, and
transfer a measurement of at least one broadband radiation reflected from within the vascular structure,
wherein the at least one broadband radiation comprises a first broadband radiation acquired from a region of interest within the vascular structure, wherein an occluding structure is located within the region of interest and the first broadband radiation is associated with the occluding structure, wherein the first broadband radiation comprises radiation reflected from the formed occluding structure, and wherein the at least one broadband radiation comprises a second broadband radiation that comprises radiation reflected from blood or a vessel wall located near the formed occluding structure within the vascular structure;

a spectral resolving device configured to provide at least one spectrally resolved data set, the spectral resolving device being a wavelength resolving device configure to determine the at least one spectrally resolved data set, the at least one spectrally resolved data set comprising a first spectrally resolved data set, including a spectrum of the formed occluding structure, determined based on the first broadband radiation and a second spectrally resolved data set, including a spectrum of the blood or the vessel wall located near the formed occluding structure, determined based on the second broadband radiation;
a processor configured to:
receive the first spectrally resolved data set and the second spectrally resolved data set,
identify the formed occluding structure in the vascular structure,
detect whether the formed occluding structure is a blood clot based on comparing (i) the spectrum of the formed occluding structure to (ii) the spectrum of the blood or the vessel wall located near the formed occluding structure, and
determine information relating to the occluding structure, including type of the blood clot if the occluding structure is the blood clot, based on determination of a ratio between (i) the spectrum of the occluding structure and (ii) the spectrum of the blood or the vessel wall located near the occluding structure; and
an output unit configured to output the information relating to the occluding structure.

2. The system according to claim 1 , wherein the second broadband radiation is reflected from the region of interest.

3. The system according to claim 1 , wherein the occluding structure is the blood clot and determination of the information relating to the blood clot comprises a differentiation between a first blood clot type that is rich in red blood cells and a second blood clot type that is rich in fibrin.

4. The system according to claim 3 , wherein the differentiation between the first blood clot type and the second blood clot type comprises a determination of at least one physiological parameter comprising one or more of: amount of haemoglobin; haemoglobin oxygen saturation; an amount of scattering; a vessel packaging parameter; water content; and the amount of at least one haemoglobin derivative.

5. The system according to claim 4 , wherein the determination of the at least one physiological parameter comprises one or more of: a fitting of an optical model to the at least one spectrally resolved data set; application of at least one multivariate analysis tool to the at least one spectrally resolved data set; a partial least squares discriminant analysis of the at least one spectrally resolved data set; application of support vector machines to the at least one spectrally resolved data set; application of a k nearest neighbor analysis; and application of deep learning algorithms to the at least one spectrally resolved data set.

6. The system according to claim 4 , wherein the differentiation between the first blood clot type and the second blood clot type comprises utilization of a look-up-table.

7. The system according to claim 1 , wherein the at least one broadband radiation comprises radiation in the range 400 nm to 800 nm.

8. The system according to claim 1 , wherein the occluding structure is the blood clot and the information relating to the blood clot comprises one or more of: an evaluation of which thrombectomy device or devices is or are most suitable for removal of the blood clot; an assessment of the physical consistency of the blood clot; an assessment of the density of the blood clot; and an assessment of the fibrin content of the blood clot.

9. A method for determining information relating to an occluding structure, comprising:
identifying an occluding structure formed within a vascular structure;
positioning at least one optical fiber to transfer broadband radiation toward the formed occluding structure and measuring a first broadband radiation reflected from the formed occluding structure;
positioning the at least one optical fiber to transfer broadband radiation away from the occluding structure and toward blood or a vessel wall located near the formed occluding structure and measuring a second broadband radiation reflected from the blood or the vessel wall located near the formed occluding structure;
determining at least one spectrally resolved data set, wherein the at least one spectrally resolved data set comprising a first spectrally resolved data set, including a spectrum of the formed occluding structure, determined based on the first broadband radiation and a second spectrally resolved data set, including a spectrum of the blood or the vessel wall located near the formed occluding structure, determined based on the second broadband radiation;
providing the first spectrally resolved data set and the second spectrally resolved data set;
detecting whether the occluding structure is a blood clot based on comparing (i) the spectrum of the formed occluding structure to (ii) the spectrum of the blood or the vessel wall located near the formed occluding structure;
determining information relating to the occluding structure, including type of the blood clot if the occluding structure is the blood clot, based on determination of a ratio between ci) the spectrum of the occluding structure and (ii) the spectrum of the blood or the vessel wall located near the occluding structure; and
outputting the information relating to the occluding structure.

10. The method according to claim 9 , wherein the second broadband radiation is reflected from the region of interest.

11. The method according to claim 9 , wherein the occluding structure is the blood clot and determination of the information relating to the blood clot comprises a differentiation between a first blood clot type that is rich in red blood cells and a second blood clot type that is rich in fibrin.

12. The method according to claim 11 , wherein the differentiation between the first blood clot type and the second blood clot type comprises a determination of at least one physiological parameter comprising one or more of: amount of haemoglobin; haemoglobin oxygen saturation; an amount of scattering; a vessel packaging parameter; water content; and the amount of at least one haemoglobin derivative.

13. The method according to claim 12 , wherein the determination of the at least one physiological parameter comprises one or more of: a fitting of an optical model to the at least one spectrally resolved data set; application of at least one multivariate analysis tool to the at least one spectrally resolved data set; a partial least squares discriminant analysis of the at least o

Assignees

• Koninklijke Philips Nv

Inventors

• Mueller Manfred
• Van Der Horst Arjen
• Lucassen Gerhardus Wilhelmus
• Hendriks Bernardus Hendrikus Wilhelmus
• Sio Charles Frederik

Classifications

• A61B5/0261

  using optical means, e.g. infrared light · CPC title

• A61B5/0075

  by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence) · CPC title

• A61B5/02007 Primary

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• A61B5/0084

  for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence) · CPC title

• A61B5/1459

  invasive, e.g. introduced into the body by a catheter · CPC title