Process for removing strontium ions from bodily fluids using metallate ion exchange compositions

Patent metadata

Field	Value
Publication number	US-11577014-B2
Application number	US-201916506465-A
Country	US
Kind code	B2
Filing date	Jul 9, 2019
Priority date	Jul 9, 2019
Publication date	Feb 14, 2023
Grant date	Feb 14, 2023

Abstract

A process for removing Sr2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchanger to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchanger. The ion exchangers are represented by the following empirical formula:AmZraTibSncMdSixOy.A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.

First claim

We claim as our invention:

1. A process for removing Sr 2+ toxins from bodily fluids selected from the group consisting of blood, gastrointestinal fluids and dialysate solution comprising contacting the fluid containing the toxins with a metallate ion exchanger at ion exchange conditions thereby removing the toxins from the fluid, the metallate ion exchanger selected from the group consisting of zirconium metallate, titanium metallate, tin metallate, multinary metallate containing more than one of zirconium, titanium and tin, and mixtures thereof, the metallates respectively having an empirical formula on an anhydrous basis of:
A m Zr a Ti b Sn c M d Si x O y

where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, rubidium ion, cesium ion, calcium ion, magnesium ion, hydronium ion or mixtures thereof, M is at least one framework metal selected from the group consisting of hafnium (4+) or niobium (5+), “m” is the mole ratio of A to total metal (total metal=Zr+Ti+Sn+M) and has a value from 0.10 to 9, “a” is the mole fraction of the total metal that is Zr and has a value from zero to 1, “b” is the mole fraction of the total metal that is Ti and has a value from zero to 1, “c” is the mole fraction of the total metal that is Sn and has a value from zero to 1, a+b+c>0, “d” is the mole fraction of the total metal that is M and has a value from zero to less than 1, a+b+c+d=1 and, “x” has a value from 0 to 6, and “y” has a value from 2.1 to 19.

2. The process of claim 1 wherein the bodily fluid is selected from whole blood, blood plasma, or other component of blood, gastrointestinal fluids and dialysate solution containing blood, blood plasma, other component of blood or gastrointestinal fluids.

3. The process of claim 1 where M is hafnium (+4) or niobium (5+).

4. The process of claim 1 where x=0.

5. The process of claim 1 where a+c+d=0.

6. The process of claim 1 where A is a mixture of calcium and sodium.

7. The process of claim 1 wherein the ion exchanger is packed into hollow fibers incorporated into a membrane.

8. The process of claim 1 wherein said ion exchanger comprises particles coated with a coating comprising a cellulose derivative composition.

9. The process of claim 1 wherein said process is a hemoperfusion process wherein said bodily fluid is sent through a column containing said ion exchanger.

10. The process of claim 1 wherein said ion exchanger regenerates a dialysate solution.

11. The process of claim 1 wherein a dialysate solution is introduced into a peritoneal cavity and then is flowed through at least one adsorbent bed containing at least one of said ion exchanger.

12. The process of claim 1 wherein said ion exchanger is formed into a shaped article to be ingested orally and to pick up said toxins from a gastrointestinal fluid in a mammal's intestines followed by excretion of a pill containing said toxins.

Assignees

• Uop Llc

Inventors

• Lewis Gregory John
• Jakubczak Paulina
• Marte Julio C
• Sheets William Christopher

Classifications

• B01D69/108

  Inorganic support material · CPC title

• A61M1/1678

  intracorporal (peritoneal dialysis A61M1/28) · CPC title

• B01D69/02

  characterised by their properties · CPC title

• A61M1/3486

  Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents · CPC title

• B01J39/09

  Inorganic material · CPC title