Systems and methods for assessing heart function

Patent metadata

Field	Value
Publication number	US-11576604-B2
Application number	US-202016870134-A
Country	US
Kind code	B2
Filing date	May 8, 2020
Priority date	Nov 3, 2010
Publication date	Feb 14, 2023
Grant date	Feb 14, 2023

Abstract

Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.

First claim

What is claimed is:

1. A system, comprising:
a computing device configured to store data and execute machine readable instructions, the data including electrical data representing measurements of cardiac electrophysiological activity for a plurality of points across at least one spatial region of a surface of a heart of a patient, the electrical data being reconstructed for the at least one spatial region of the heart that includes the plurality of points based on cardiac signals measured non-invasively and concurrently via sensors distributed across an outer surface of a body of the patient, the instructions to compute at least one indication of synchrony based on an analysis of the electrical data for the at least one spatial region of the surface of the heart, the at least one indication of synchrony providing a quantitative assessment of at least one of a heart electrical function, a heart mechanical function or a hemodynamic performance, wherein the instructions of the computing device are further configured to determine a treatment location based on the at least one indication of synchrony, the treatment location being determined based on the measurements of cardiac electrophysiological activity.

2. The system of claim 1 , wherein the the measurements of cardiac electrophysiological activity are acquired intraoperatively to provide spatial guidance to identify one or more sites for delivering a therapy to the patient.

3. The system of claim 1 , further comprising a therapy system to deliver a therapy based on at least one therapy parameter, the at least one therapy parameter being computed based on the at least one indication of synchrony, the computing device being configured to adjust the at least one therapy parameter in response to feedback corresponding to updated measurements of cardiac electrophysiological activity.

4. The system of claim 1 , wherein the instructions of the computing device are further configured to determine at least one therapy parameter for a therapy based on the at least one indication of synchrony, the at least one therapy parameter comprising at least one of a quantity of the therapy, a duration of the therapy and a time between delivery of consecutive therapies.

5. The system of claim 1 , wherein the plurality of points across the at least one spatial region of the surface of the heart of the patient are divided into a plurality of spatial regions, each spatial region comprising some of the plurality of points, the instructions are further configured to compute a respective indication of synchrony for each of the plurality of spatial regions and to quantify synchrony for the heart based on a comparison of the respective indication of synchrony computed for each of the plurality of spatial regions.

6. The system of claim 1 , wherein the instructions are further configured to:
compute time-based electrical characteristics for the plurality of points based on the measurements of cardiac electrophysiological activity during at least one time interval;
calculate a standard deviation values for a plurality of spatial segments distributed across the at least one spatial region of the heart based on the computed time-based electrical characteristics of the plurality of points within each respective segment; and
identify at least one of the plurality spatial segments having an increased dispersion for the time-based electrical characteristics relative to other spatial segments of the plurality of spatial segments based on the calculated standard deviation values.

7. The system of claim 6 , further comprising a therapy system to deliver a therapy to the heart based on at least one therapy parameter to decrease the dispersion for the time-based electrical characteristics in the at least one identified spatial segment relative to the other spatial segments, the at least one therapy parameter being computed based on the at least one indication of synchrony.

8. The system of claim 1 , wherein the instructions of the computing device are further configured to:
compute the at least one indication of synchrony based on the electrical data that is acquired non-invasively via the sensors distributed on the outer surface of the body of the patient and other electrical data acquired invasively via one or more sensors within the body of the patient; and
generate map data to display the at least one indication of synchrony.

9. The system of claim 1 , wherein the instructions of the computing device are further configured to:
identify at least one area of the heart that does not contribute to mechanical function; and
exclude the identified at least one area from the at least one spatial region of the heart, such that the electrical data for points residing in each excluded area are not used in computing the at least one indication of synchrony.

10. The system of claim 9 , wherein the instructions of the computing device are further configured to:
determine at least one therapy parameter based on the at least one indication of synchrony; and
cause a therapy system to deliver a therapy based on the at least one therapy parameter.

11. The system of claim 10 , further comprising the therapy system, wherein the computing device is configured to control the therapy system based on the at least one therapy parameter and to adjust the at least one therapy parameter in response to changes in the at least one indication of synchrony computed from updated cardiac signals acquired from the patient.

12. The system of claim 11 , wherein the instructions of the computing device are further configured to:
compute the at least one indication of synchrony based on the electrical data that is acquired non-invasively via the sensors distributed on the outer surface of the body of the patient and invasively via one or more other sensors within the body of the patient; and
generate map data to display the at least one indication of synchrony.

13. A system, comprising:
a computing device configured to store data and execute machine readable instructions, the data including electrical data representing measurements of cardiac electrophysiological activity for a plurality of points across at least one spatial region of a surface of a heart of a patient, the electrical data being reconstructed for the at least one spatial region of the heart that includes the plurality of points based on cardiac signals measured non-invasively and concurrently via sensors distributed across an outer surface of a body of the patient,
wherein the plurality of points across the at least one spatial region of the surface of the heart of the patient are divided into a plurality of spatial regions, each spatial region comprising some of the plurality of points, and
wherein the instructions are further configured to compute at least one indication of synchrony based on an analysis of the electrical data to provide an assessment of mechanical synchrony of the heart based on electrical measurements by weighting each of the plurality of spatial regions according to a respective contribution to the heart mechanical function and/or the hemodynamic performance.

14. A system, comprising:
a computing device configured to store data and execute machine readable instructions, the data including electrical data representing measurements of cardiac electrophysiological activity for a plurality of points across at least one spatial region of a surface of a heart of a patient, the electrical data being reconstructed for the at least one spatial region of the heart that includes the plurality of points based on cardiac signals measured non-invasively and concurrently via sensors dis

Assignees

• Cardioinsight Technologies Inc

Inventors

• Ramanathan Charulatha
• Wodlinger Harold
• Strom Maria
• Arless Steven G
• Jia Ping

Classifications

• A61B5/283

  Invasive · CPC title

• A61B5/349 Primary

  Detecting specific parameters of the electrocardiograph cycle · CPC title

• A61N1/3627

  for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy · CPC title

• A61B5/287

  Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS] · CPC title

• A61B5/316 Primary

  Modalities, i.e. specific diagnostic methods · CPC title