Organ perfusion device

Patent metadata

Field	Value
Publication number	US-11576371-B2
Application number	US-201816622066-A
Country	US
Kind code	B2
Filing date	Jun 12, 2018
Priority date	Jun 13, 2017
Publication date	Feb 14, 2023
Grant date	Feb 14, 2023

Abstract

Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.

First claim

The invention claimed is:

1. A device for perfusing an organ, said device comprising:
a fluid container, arranged in order to contain an organ immersed in a perfusion fluid,
a first channel comprising an inlet arranged in order to be submerged in the container, an outlet arranged in order to be submerged in the container, and at least one pump arranged in order to circulate the fluid from the inlet to the outlet of the first channel,
a second channel comprising an inlet arranged in order to be submerged in the container, an outlet arranged in order to be submerged in the container, and at least one pump arranged in order to circulate the fluid from the inlet to the outlet of the second channel,
the outlet of the first channel being separate from the outlet of the second channel, the outlet of the first channel having a diameter smaller than the diameter of the outlet of the second channel,
the device further comprising, between the pump of the first channel and the outlet of the first channel and/or between the pump of the second channel and the outlet of the second channel, means for oxygenating the fluid, arranged in order to create a difference in the oxygenation of the fluid between the outlet of the first channel and the outlet of the second channel,
the oxygenation means being arranged in order to give more oxygen to the fluid leaving the outlet of the first channel than to the fluid leaving the outlet of the second channel.

2. The device according to claim 1 , further comprising oxygenation means between the pump of the first channel and the outlet of the first channel.

3. The device according to claim 1 , wherein the device does not comprise oxygenation means on the second channel.

4. The device according to claim 1 , wherein the pump of the first channel and/or the pump of the second channel is a peristaltic pump.

5. The device according to claim 1 , further comprising means for regulating the temperature of the fluid between the pump of the second channel and the outlet of the second channel.

6. The device according to claim 1 , wherein the device does not comprise means for regulating the temperature of the fluid on the first channel.

7. The device according to claim 1 , wherein the inlet of the first channel and the inlet of the second channel are one and the same common inlet.

8. The device according to claim 7 , further comprising:
between the common inlet and the pump of the first channel, and
between the common inlet and the pump of the second channel,
a separator between the first channel and the second channel.

9. The device according to claim 8 , further comprising,
between the common inlet and the separator, a pump common to the first channel and the second channel.

10. The device according to claim 9 , further comprising,
between the common inlet and the separator, a reservoir common to the first channel and the second channel.

11. The device according to claim 10 , wherein the common reservoir is placed between the common pump and the separator.

12. The device according to claim 10 , wherein the common reservoir is equipped with dialysis means, placed on a circuit parallel to the first channel and parallel to the second channel, the dialysis means comprising an inlet leaving from the common reservoir and an outlet arriving in the common reservoir.

13. The device according to claim 10 , wherein the common reservoir is equipped with a bubble trap.

14. The device according to claim 1 , wherein the inner diameter of the outlet of the first channel is less than or equal to 12 mm and/or greater than or equal to 5 mm.

15. The device according to claim 1 , wherein the inner diameter of the outlet of the second channel is less than or equal to 12 mm and/or greater than or equal to 5 mm.

16. The device according to claim 1 , wherein the pump of the first channel and the pump of the second channel are arranged and/or programmed so that the fluid has a flow rate at the outlet of the second channel that is greater than a flow rate at the outlet of the first channel.

17. The device according to claim 1 , wherein the inlet of the first channel and/or the inlet of the second channel does not have a cannula.

18. The device according to claim 1 , further comprising means for regulating the temperature of the container.

19. The device according to claim 1 , further comprising a first pressure sensor arranged in order to measure the pressure of the fluid in the first channel at less than 10 cm from the outlet of the first channel, between the pump of the first channel and the outlet of the first channel.

20. The device according to claim 19 , further comprising means for controlling the pump of the first channel so as to regulate the flow rate of the pump of the first channel as a function of pressure measurement data provided by the first pressure sensor.

21. The device according to claim 1 , further comprising a second pressure sensor arranged in order to measure the pressure of the fluid in the second channel at less than 10 cm from the outlet of the second channel, between the pump of the second channel and the outlet of the second channel.

22. The device according to claim 21 , further comprising means for controlling the pump of the second channel so as to regulate the flow rate of the pump of the second channel as a function of pressure measurement data provided by the second pressure sensor.

23. The device according to claim 1 , further comprising a communication channel between the first channel and the second channel, the communication channel starting from the first channel between the oxygenation means and the outlet of the first channel.

24. The device according to claim 23 , wherein the communication channel comprises a flowmeter arranged in order to measure the flow rate of fluid passing through the communication channel and/or means for regulating this flow rate.

25. A method for perfusing an organ, implemented in a device comprising:
a fluid container, containing an organ immersed in a perfusion fluid,
a first channel comprising an inlet submerged in the container, an outlet submerged in the container, and at least one pump circulating the fluid from the inlet to the outlet of the first channel,
a second channel comprising an inlet submerged in the container, an outlet submerged in the container, and at least one pump circulating the fluid from the inlet to the outlet of the second channel,
the outlet of the first channel being separate from the outlet of the second channel, the outlet of the first channel having a diameter smaller than the diameter of the outlet of the second channel,
wherein the method comprises, between the pump of the first channel and the outlet of the first channel and/or between the pump of the second channel and the outlet of the second channel, creating, by oxygenation means, a difference in the oxygenation of the fluid between the outlet of the first channel and the outlet of the second channel,
creating the difference in the oxygenation giving more oxygen to the fluid leaving the outlet of the first channel than to the fluid leaving the outlet of the second channel.

26. The method according to claim 25 , wherein the organ is perfused by the fluid which is initially at a minimum temperature comprised between 0 and 10° C., before being reheated gradually by the fluid, this fluid gradually reaching a maximum temperature comprised between 3

Assignees

• Univ De Technologie De Compiegne
• Centre Nat Rech Scient
• Univ Sorbonne
• Inst Nat Sante Rech Med
• Hopitaux Paris Assist Publique

Inventors

• Legallais Cécile
• Paullier Patrick
• Scatton Olivier
• Savier Eric

Classifications

• A01N1/143 Primary

  for organ perfusion · CPC title

• A01N1/0247 Primary

  Human Necessities · mapped topic