Automated system for processing a biological fluid

Patent metadata

Field	Value
Publication number	US-11566225-B2
Application number	US-201414505816-A
Country	US
Kind code	B2
Filing date	Oct 3, 2014
Priority date	Oct 3, 2014
Publication date	Jan 31, 2023
Grant date	Jan 31, 2023

Abstract

Systems and methods for processing biological fluids are disclosed. The systems and methods use a reusable hardware unit and a disposable fluid processing circuit that mounts onto the reusable hardware unit. The system and method, under the direction of a pre-programmed controller allow for automatically, opening one or more flow paths to effect addition of one or both parts of an additive solution to a biological fluid component.

First claim

The invention claimed is:

1. A method for processing red blood cells and combining said red blood cells with at least one part of a two-part red blood cell additive solution, said method comprising:
a) mounting onto a reusable hardware unit, selected pre-attached containers of a disposable fluid processing circuit, said fluid circuit comprising (i) a container of blood that has been separated into two or more components wherein one of said separated components comprises red blood cells, (ii) a subassembly of containers of at least three containers wherein a first of said containers contains a first part of an additive solution selected for the prolonged storage of red blood cells, a second of said containers contains a second part of said additive solution downstream of said first of said containers, a third container downstream of said second of said containers for receiving said red blood cells from said container of blood that has been separated into two or more components, a leukoreduction filter downstream of said container for receiving said red blood cells and a filtrate container downstream of said leukoreduction filter, (iii) openable flow paths joining said at least first, second and third containers, and (iv) a flow blocker in an openable flow path,
said reusable hardware unit including (i) two container holders wherein said first and second containers of said subassembly are each separately received within said two container holders and wherein said two container holders include press plates, (ii) a flow path opening device associated with each of said two container holders and (iii) a controller configured to actuate said flow path opening device and activate said press plates of said container holders at a selected time;

b) placing said container of blood that has been separated into blood components in a container holder of said reusable hardware unit;
c) activating the press plates of said holder in which said container of blood is placed and expressing at least said red blood cells to said container for receiving said red blood cells;
d) placing said first and second containers of said subassembly in said two container holders, respectively and automatically opening a flow path between said third container and at least said second container of said subassembly; and
e) activating said press plate holding said second container to express therefrom a selected amount of the contents of the second container to the third container to obtain a combined suspension of said red blood cells and said selected amount of the contents of said second container.

2. The method of claim 1 further comprising passing the combined suspension of said red blood cells and said selected amount of the contents of said second container through said leukoreduction filter to collect in the filtrate container.

3. The method of claim 2 comprising, after collecting the combined suspension in the filtrate container, automatically opening a flow path between said first container and said second container of said subassembly.

4. The method of claim 3 further comprising, after automatically opening the flow path between said first container and said second container, flowing the first part of the additive solution through the second container, the third container, and then through the leukoreduction filter to rinse said leukoreduction filter with said first part of said additive solution.

5. The method of claim 4 further comprising collecting the first part of the additive solution in the filtrate container after passing it through the leukoreduction filter, thereby combining the first part of the additive solution with the combined suspension of said red blood cells and said selected amount of the contents of said second container.

6. The method of claim 1 comprising automatically opening flow paths between the container for receiving said red blood cells and (a) the first container containing said first part of the additive solution and (b) the second container containing said second part of the additive solution under the direction of the controller.

7. The method of claim 1 comprising mounting said first container containing a first part of an additive solution onto said reusable hardware unit, mounting said second container containing said second part of said additive solution onto said reusable hardware unit, and associating and aligning a flow blocker in a flow path between one of said first and second containers and said third container with a flow path opening device of said reusable hardware unit.

8. The method of claim 1 wherein said first and second containers of said subassembly are made of flexible material and are compressible.

9. The method of claim 1 further comprising activating said press plates of said two container holders sequentially.

10. The method of claim 1 comprising removing said container of blood that has been separated into two or more components from said reusable hardware unit prior to mounting said containers of said subassembly onto said reusable hardware unit.

11. The method of claim 10 comprising placing one of said first and second containers of said subassembly into said holder from which said container of blood that has been separated into two or more components has been removed and activating said press plate.

Assignees

• Fenwal Inc

Inventors

• Lynn Daniel
• Radwanski Katherine

Classifications

• A61M1/0272

  Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging · CPC title

• C12N5/0641 Primary

  Erythrocytes · CPC title

• A61M1/0209 Primary

  Multiple bag systems for separating or storing blood components · CPC title

• A61M2202/0429

  Red blood cells; Erythrocytes · CPC title