Ras inhibitors
US-2021130303-A1 · May 6, 2021 · US
US11566007B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11566007-B2 |
| Application number | US-202017089035-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 4, 2020 |
| Priority date | Nov 4, 2019 |
| Publication date | Jan 31, 2023 |
| Grant date | Jan 31, 2023 |
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The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.
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The invention claimed is: 1. A compound, or a pharmaceutically acceptable salt thereof, selected from the following compounds: Ex # Structure A202 A248 A276 A277 A278 A279 A286 A287 A288 A314 A330 A331 A340 A347 A447 A468 A506 A520 A521 A694 A728 . 2. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable excipient.
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