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US-2015335613-A1 · Nov 26, 2015 · US
Compositions and methods for combinatorial drug discovery in nanoliter droplets
US11564970B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11564970-B2 |
| Application number | US-201816754668-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 9, 2018 |
| Priority date | Oct 9, 2017 |
| Publication date | Jan 31, 2023 |
| Grant date | Jan 31, 2023 |
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- Title
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- Abstract
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Abstract
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Compositions and methods for combinatorial drug discovery in nanoliter droplets are described. Novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infection are disclosed.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition comprising an antibiotic selected from the group consisting of vancomycin, cycloserine, fosfomycin, novobiocin, erythromycin, tetracycline, ampicillin, trimethoprim, chloramphenicol, and norflaxacin, and combinations thereof and Iodophenpropit. 2. The composition of claim 1 , wherein the antibiotic is novobiocin. 3. The composition of claim 1 , wherein the antibiotic is erythromycin. 4. The composition of claim 1 , wherein the antibiotic is chloramphenicol. 5. The composition of claim 1 , wherein the antibiotic is vancomycin. 6. A method of treating a subject having a bacterial infection comprising administering to the subject a composition of claim 1 . 7. A method of potentiating antibacterial activity of an antibiotic in a subject having a bacterial infection comprising administering to the subject the antibiotic with a composition of claim 1 .
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Classifications
having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} · CPC title
1,3-Diazoles · CPC title
- A61K38/12Primary
Cyclic peptides {, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C (A61K38/043 - A61K38/046 take precedence)} · CPC title
not condensed and containing further heterocyclic rings · CPC title
Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205) · CPC title
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Frequently asked questions
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- What does patent US11564970B2 cover?
- Compositions and methods for combinatorial drug discovery in nanoliter droplets are described. Novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infection are disclosed.
- Who is the assignee on this patent?
- Broad Inst Inc, Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification A61K38/12. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jan 31 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).