Lactobacillus plantarum with colorectal cancer inhibition function and use thereof

Patent metadata

Field	Value
Publication number	US-11564956-B2
Application number	US-201816771224-A
Country	US
Kind code	B2
Filing date	Jul 19, 2018
Priority date	Nov 3, 2017
Publication date	Jan 31, 2023
Grant date	Jan 31, 2023

Abstract

The present invention relates to the technical field of microbes, in particular to a Lactobacillus plantarum which can significantly inhibit the occurrence of colorectal cancer, and its use thereof. The Lactobacillus plantarum strain CCFM164 has a deposit number CGMCC No. 14520, which has a good tolerance to gastric acid and bile salts, significantly alleviate the level of colorectal inflammation in colorectal cancer model mice, and can reduce the number of tumors in the colon and rectum of the model mice by regulating the Notch1, Notch2 signaling pathway and the expression of VEGFR2 molecule in colorectal tissue. In addition, the Lactobacillus plantarum CCFM164 can also improve the intestinal flora population and short-chain fatty acid levels in the intestine. The Lactobacillus plantarum CCFM164 is used to prepare a fermented food for the inhibition of the occurrence of colorectal cancer with wild applications.

First claim

What is claimed is:

1. A method for improving an intestinal flora, reducing abnormally high levels of short chain fatty acids in an intestine, alleviating a colorectal inflammation, and inhibiting a colorectal cancer, wherein the method comprises administering to a subject in need thereof a composition comprising Lactobacillus plantarum strain CCFM164 (CGMCC 14520), and wherein the Lactobacillus plantarum strain CCFM164 (CGMCC 14520) has at least 90% survival rate after treatment in pH 2.5 for 3 hours.

2. The method according to claim 1 , wherein Lactobacillus plantarum strain CCFM164 (CGMCC 14520) has at least 75% survival rate after treatment in pH 8.0 for 3 hours.

Assignees

• Univ Jiangnan

Inventors

• Chen Wei
• Wang Gang
• Wang Eryin
• Zhao Jianxin
• Zhang Hao

Classifications

• A23Y2220/67

  Human Necessities · mapped topic

• A23C9/1234

  characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp. · CPC title

• C12N1/205

  Bacterial isolates · CPC title

• A61P1/14 Primary

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A23L11/50

  Fermented pulses or legumes; Fermentation of pulses or legumes based on the addition of microorganisms (removing undesirable substances A23L11/30; soy sauce A23L27/50) · CPC title