Therapeutic agent targeting and fixation medical device using magnet array

Patent metadata

Field	Value
Publication number	US-11564881-B2
Application number	US-201816015662-A
Country	US
Kind code	B2
Filing date	Jun 22, 2018
Priority date	Jun 23, 2017
Publication date	Jan 31, 2023
Grant date	Jan 31, 2023

Abstract

Provided is a therapeutic agent targeting and fixation medical device that precisely targets a therapeutic agent including a magnetic substance by using an optimized array of magnets in consideration of an affected area of a patient.

First claim

What is claimed is:

1. A method of manufacturing a medical device for targeting and fixing a therapeutic agent comprising a magnetic substance to an affected area by using an array of a plurality of magnets, the method comprising:
acquiring a 3-D medical image of the affected area of a patient by using an imaging device;
extracting the affected area and setting a treatment region in order to measure a shape, a size, and a position of the affected area;
designing a patient-specific medical device for targeting and fixing the therapeutic agent comprising the magnetic substance in order to design a distribution, a number, and a magnetization direction of the magnets on a basis of the 3-D medical image acquired from the patient, wherein the plurality of magnets are arranged in a space surrounding a stacking point and/or a target point, and wherein the plurality of magnets delete a magnetic flux density by overlapping magnetic fields; and
manufacturing a magnet arrangement device for attaching around the affected area so as to determine a shape of the magnet arrangement device on the basis of the distribution, number, and magnetization direction of the magnets.

2. The method of claim 1 , wherein the designing of a medical device for targeting and fixing a therapeutic agent comprises:
setting initial values of a maximum magnet array range, the number of magnets to be used, and an initial magnet magnetization direction;
calculating an initial magnetic force in a specific direction at a point of interest (POI);
changing the magnet magnetization direction to determine a magnetic force and a magnetization direction so that the calculated magnetic force has a maximum value;
comparing a magnitude of a magnetic force in a previous process with that of a magnetic force in a current process;
checking the number of magnets to be used; and
arranging the magnets on the basis of the determined magnet magnetization direction.

3. The method of claim 1 , wherein the imaging device comprises X-ray, CT, PET, or MRI.

4. The method of claim 1 , wherein the magnet arrangement device is a detachable-type or a fixed-type.

5. The method of claim 1 , wherein the therapeutic agent comprising the magnetic substance comprises a medicine comprised of or attached with magnetic nanoparticles, a cell therapeutic agent, or a mixture thereof.

6. The method of claim 5 , wherein the cell therapeutic agent comprises a mesenchymal cell, a cartilage cell, a bone cell, a neural stem cell, a stem cell, or an immune cell.

7. A medical device for targeting and fixing the therapeutic agent comprising the magnetic substance to the affected area by using the array of the plurality of magnets, wherein the medical device is manufactured by the method of claim 1 .

8. A medical kit for magnet-based affected area treatment comprising the medical device for targeting and fixing the therapeutic agent comprising the magnetic substance to the affected area by using the array of the plurality of magnet of claim 7 and the therapeutic agent comprising the magnetic substance.

9. The medical kit of claim 8 , wherein the therapeutic agent comprising the magnetic substance comprises a medicine comprised of or attached with magnetic nanoparticles, a cell therapeutic agent, or a mixture thereof.

10. The medical kit of claim 9 , wherein the cell therapeutic agent comprises a mesenchymal cell, a cartilage cell, a bone cell, a neural stem cell, a stem cell, or an immune cell.

Assignees

• Univ Nat Chonnam Ind Found

Inventors

• Park Jongoh
• Choi Eunpyo
• Kim Chang-Sei
• Kang Byungjeon
• Go Gwangjun
• Lee Kyungmin
• Han Jiwon

Classifications

• A61K9/0009 Primary

  involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis · CPC title

• A61B2034/731

  Arrangement of the coils or magnets · CPC title

• A61B5/1075

  for measuring dimensions by non-invasive methods, e.g. for determining thickness of tissue layer (A61B8/0858 takes precedence) · CPC title

• A61B34/73

  Manipulators for magnetic surgery · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title