Hydrogel and method for preparing the same

Patent metadata

Field	Value
Publication number	US-11559476-B2
Application number	US-202016913323-A
Country	US
Kind code	B2
Filing date	Jun 26, 2020
Priority date	Jun 27, 2019
Publication date	Jan 24, 2023
Grant date	Jan 24, 2023

Abstract

The present application provides a method for preparing a hydrogel and the obtained hydrogel. The method including: forming a first part by mixing a first single-stranded nucleotide with a first liposome, and forming a second part by mixing a second single-stranded nucleotide with a second liposome, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends; forming a hydrogel by mixing the first part and the second part.

First claim

The invention claimed is:

1. A hydrogel comprising a plurality of first single-stranded nucleotides, a plurality of first liposomes, a plurality of second single-stranded nucleotides and a plurality of second liposomes, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends, wherein the hydrogel includes a linker and where the linker is a cell penetrating peptide.

2. The hydrogel according to claim 1 , wherein the first single-stranded nucleotide and the second single-stranded nucleotide are both single-stranded oligonucleotides.

3. The hydrogel according to claim 1 , wherein the first or second liposome contains a load material.

4. The hydrogel according to claim 3 , wherein the load material is a medicine or a cosmetic.

5. A method for preparing a hydrogel, including:
forming a first part by mixing a first single-stranded nucleotide with a first liposome, and forming a second part by mixing a second single-stranded nucleotide with a second liposome, wherein the first single-stranded nucleotide and the second single-stranded nucleotide have complementary sticky ends;
forming a hydrogel by mixing the first part and the second part, wherein the hydrogel includes a linker and where the linker is a cell penetrating peptide.

6. The method for preparing a hydrogel according to claim 5 , wherein the first single-stranded nucleotide and the second single-stranded nucleotide are both single-stranded oligonucleotides.

7. The method for preparing a hydrogel according to claim 5 , wherein before forming the first part and the second part, the method further includes:
mixing a load material with the first liposome and/or the second liposome respectively, so as to make the first liposome and/or the second liposome encapsulate the load material.

8. The method for preparing a hydrogel according to claim 7 , wherein the load material is a medicine or a cosmetic.

9. The method for preparing a hydrogel according to claim 7 , wherein after forming the hydrogel, the method further includes:
releasing at least part of the load material from the first liposome and the second liposome by adding a surfactant to the hydrogel.

10. The method for preparing a hydrogel according to claim 5 , wherein said forming the first part and forming the second part include:
mixing the first single-stranded nucleotide, the first liposome and a linker, and connecting the first single-stranded nucleotide with the first liposome through the linker to obtain the first part; mixing the second single-stranded nucleotide, the second liposome and a linker, and connecting the second single-stranded nucleotide with the second liposome through the linker to obtain the second part.

11. The method for preparing a hydrogel according to claim 10 , wherein the linker is a cell-penetrating peptide.

Assignees

• Boe Technology Group Co Ltd

Inventors

• Yin Yudan

Classifications

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K47/6911

  the form being a liposome · CPC title

• A61K31/715 Primary

  Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters · CPC title

• A61K47/549

  Sugars, nucleosides, nucleotides or nucleic acids · CPC title